Marissa Fayer: Advancing AI, Medical Imaging, and the Future of Women’s Health

What does it take to turn decades of healthcare experience into technology that could help improve cancer detection and patient care?

In this episode of Entrepreneur Rx, host John Shufeldt sits down with Marissa Fayer, CEO of DeepLook Medical, to discuss her journey from corporate medtech executive to entrepreneur, investor, nonprofit founder, and women’s health advocate.

Marissa shares how her background in engineering, manufacturing, medical devices, and global healthcare shaped her approach to innovation. The conversation explores her corporate healthcare career, her work developing 3D mammography systems, global disparities in women’s health, and the path that led her to DeepLook Medical.

The episode also looks, at DeepLook’s AI-powered imaging technology, designed to help radiologists and oncologists better visualize dense tissue, track tumors over time, and support clinical decisions. Marissa explains why dense breast tissue can make cancer harder to see, how visual intelligence can serve as a second pair of eyes for clinicians, and why better imaging tools may help improve follow-up.

Beyond the technology, John and Marissa discuss leading a startup, building partnerships, fundraising, working toward standard of care, and balancing innovation with the rigor required in medicine. Marissa shares advice for founders, especially women and engineers, on asking more questions, taking the leap, shedding perfectionism, and creating something meaningful.

About Marissa Fayer: Marissa Fayer is a medtech executive and investor with more than 25 years at the intersection of technology and women’s health. She’s CEO of DeepLook Medical, an FDA-cleared AI diagnostics company, and CEO and founder of HERhealthEQ, a nonprofit that’s improved the health outcomes of 135,000+ women in 12 different countries by expanding access to medical devices and equipment. She’s a founding member of Milken Institute’s Women's Health Committee, represents DeepLook Medical as a World Economic Forum Technology Pioneer fellow, and has published the book "Undervalued to Unavoidable: Women's Health as Infrastructure".

About DeepLook Medical: DeepLook Medical focuses on visual enhancement technology to advance medical imaging. DL Precise™ is the first in a series of innovative products using the company’s unique shape-recognition software to delineate the details of tumor morphology – a key to better diagnosis and treatment across the field of oncology. The company is leveraging other complementary AI advances to further the reach and impact of its patented technology. To learn more, please visit: https://www.deeplookmedical.com/

About Xcellerant Ventures: Xcellerant is a venture capital firm that invests in innovative companies across healthcare, technology, defense, and other emerging industries. Through multiple funds and investment vehicles, including the , the firm partners with visionary founders, provides strategic guidance, and helps connect investors with opportunities in the private markets. Its portfolio includes companies developing solutions that have the potential to transform industries and improve lives.

About Jetstream Venture Fund: Jetstream Venture Fund is an interval fund managed by Xcellerant Ventures and Sweater Industries LLC, that seeks to provide investors access to early-stage, high-growth companies with flexible terms, lower minimums ($5,000 minimum investment), and no carried interest. Jetstream is one of the first funds of its kind, bringing venture-style investing opportunities to a wider professional audience. Back-end administration is provided by Sweater Ventures a ground-breaking turnkey fund management company.

Jetstream Disclosure: Investors should carefully consider the investment objectives, risks, charges, and expenses of the Fund before investing. The prospectus contains this and other information about the Fund and can be obtained by emailing  or by visiting the . Please read the prospectus carefully before investing.