32 episodes

Minor Tweak, Major Impact is a short form podcast about scientific research methods. The show looks into a series of stories related to following protocols and how a minor tweak can produce major results, major impact.

Minor Tweak, Major Impact Minor Tweak, Major Impact

    • Science
    • 5.0 • 9 Ratings

Minor Tweak, Major Impact is a short form podcast about scientific research methods. The show looks into a series of stories related to following protocols and how a minor tweak can produce major results, major impact.

    Episode 31: Dr. Laura Volpicelli-Daley, University of Alabama at Birmingham

    Episode 31: Dr. Laura Volpicelli-Daley, University of Alabama at Birmingham

    This episode is the last one before the podcast will go into a break, but we can’t wait to be back with more stories and exciting guests later this year. In this episode we speak with Dr. Laura Volpicelli-Daley who is part of the Neurodegeneration Challenge Network. Laura is an Associate Professor in the Neurology department at the University of Alabama at Birmingham. She earned her PhD in Neuroscience in the lab of Dr. Allan Levey at Emory University where she studied how neuronal protein trafficking is disrupted in Alzheimer’s Disease. She then trained in the fundamentals of neuron cell biology at Yale University, followed by Neurodegenerative Disease training at the University of Pennsylvania. In this episode we speak with Laura about her work, her involvement with the Chan Zuckerberg Initiative Neurodegeneration Challenge Network, challenges with methods for neurodegeneration and more. Links:Volpicelli-Daley Lab - https://www.volpicellidaleylab.org/Generation and Sonication of α-synuclein Fibrils Protocol - dx.doi.org/10.17504/protocols.io.bhhrj356

    • 15 min
    Episode 30: Dr. Steven Henikoff, Fred Hutchinson Cancer Research Center

    Episode 30: Dr. Steven Henikoff, Fred Hutchinson Cancer Research Center

    In this show, we had the pleasure of speaking with Steve Henikoff who studies chromosomes, chromatin dynamics and epigenetics and develops genomics and computational tools to facilitate this research. He received a BS from the University of Chicago and a PhD from Harvard University and did post-doctoral work at the University of Washington. He has been a faculty member of the Fred Hutchinson Cancer Research Center since 1981. He is also an investigator of the Howard Hughes Medical Institute, an affiliate professor of Genome Sciences at the University of Washington, a member of the National Academy of Sciences and co-Editor-in-Chief of the open access journal Epigenetics & Chromatin. In this episode we’re talking with Steve about his work, his approach to method development and refinement, and more.Links:Steven Henikoff protocols.io publications - https://www.protocols.io/researchers/steven-henikoff/protocolsHuman Cell Atlas - https://www.humancellatlas.org/CUT&Tag@home was recently chosen by the The Scientist as one of the top 5 technical advances of 2020 - https://www.the-scientist.com/news-opinion/top-technical-advances-of-2020-68297CUT&Tag@home - https://dx.doi.org/10.17504/protocols.io.bmbfk2jneLife article ‘Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation‘ - https://doi.org/10.7554/eLife.63274Jim Watson’s book “Molecular Biology of the Gene” - https://www.amazon.com/Molecular-Biology-Fifth-James-Watson/dp/080534635XNIH ENCODE Project - https://www.genome.gov/Funded-Programs-Projects/ENCODE-Project-ENCyclopedia-Of-DNA-Elements

    • 23 min
    Episode 29: Chelsea Connor, Midwestern State University in Texas

    Episode 29: Chelsea Connor, Midwestern State University in Texas

    In this first episode of 2021, we had the pleasure of speaking with Chelsea Connor, who is a herpetologist, science communicator and artist from the Commonwealth of Dominica. Her love for animals started a long time ago and she always knew she wanted to work with animals. Never having seen someone who looked like occupying the spaces she is now and hopes to expand to, she hopes to inspire and pave the way for many other Black naturalists and nature lovers. In this episode, we’re talking with Chelsea about her work, herpetology, lizards, anoles, science communications and more.Links:DewPops stickers - https://www.redbubble.com/people/chelseaherps/shop?asc=uChelsea Connor Twitter - https://twitter.com/ChelseaHerpsChelsea Connor Website - https://chelseaconnor.carrd.co/#DidYouAnole SciComm Game - https://twitter.com/search?q=%23DidYouAnole&src=hashtag_click&f=liveAnole Annals - https://www.anoleannals.org/iNaturalist - https://www.inaturalist.org/

    • 24 min
    Episode 28: Andrew Bertera, New England Biolabs

    Episode 28: Andrew Bertera, New England Biolabs

    This is last episode for 2020 of the Minor Tweak, Major Impact podcast but don’t worry, we will be back in 2021 with more episodes and exciting guests. In this episode we are speaking with Andrew Bertera who is the Executive Director of Marketing & Sales at New England Biolabs, Inc. Andy joined New England Biolabs in 2009, having previously worked in a variety of R&D, marketing and senior management positions at Amersham, GE and Promega. As Executive Director of Marketing and Sales at NEB, Andy is responsible for the development and implementation of NEB’s marketing strategies and tactics across its entire product portfolio. Andy also oversees its US Sales and Customer Service activities and organizations. His role at NEB involves the direct management of the customer service, marketing, and sales professionals, covering the disciplines of market research, product management, channel and order management, US sales, digital marketing, and scientific and marketing communications. Andy is also the NEB representative at the Analytical, Life Science & Diagnostics Association (ALDA) Executive Management Meetings and a Board member of the Sales And Marketing Professionals in Science (SAMPS). In this episode, we are talking with Andy about his career path from the bench to the commercial side of science, challenges for NEB during the COVID-19 pandemic, protocols for vendors, and more.Links:New England Biolabs - https://www.neb.com/NEB protocols workspace - https://www.protocols.io/workspaces/new-england-biolabs-nebmyNEB™ - https://www.amazon.com/New-England-BioLabs-Biolabs/dp/B07R65WJF2

    • 25 min
    Episode 27: Dr. Véronique Kiermer, PLOS

    Episode 27: Dr. Véronique Kiermer, PLOS

    In this episode we had the pleasure of speaking with Dr. Véronique Kiermer, who is the Chief Scientific Officer at PLOS, the Public Library of Science, where she oversees the Editorial Department and initiatives to promote open science. She trained as a molecular biologist at the University of Brussels and the University of California, San Francisco, and she also worked in the biotech industry in the Bay Area. Veronique started her career in publishing as the founding Chief Editor of Nature Methods, and held several roles at Nature Publishing Group, including the Publisher for Nature Protocols, and executive editor for the Nature journals before moving to PLOS in 2015. We’re talking with Veronique about her experience with initiatives that encourage researchers to report method details, code, data, etc. as part of their research output. And you will also get a sneak preview of a new exciting initiative of PLOS in partnership with protocols.io that will be launched in early 2021.Links:Materials Design Analysis Reporting (MDAR) checklist - https://doi.org/10.31222/osf.io/9sm4xPLOS ONE - https://journals.plos.org/plosone/Show your work. Peer-Reviewed Protocols - https://theplosblog.plos.org/2020/12/show-your-work-peer-reviewed-protocols/

    • 23 min
    Episode 26: Dr. Gioia Massa, Kennedy Space Station, NASA | Plant Science Series

    Episode 26: Dr. Gioia Massa, Kennedy Space Station, NASA | Plant Science Series

    This is the fourth episode of our Plant Science Series and in this episode we are talking to Dr. Gioia Massa. On November 2nd, 2020 we celebrated the 20th anniversary of the International Space Station (ISS) and we had the pleasure of speaking with Dr. Gioia Massa who is a NASA scientist at Kennedy Space Center in Florida working on food production for the International Space Station and future exploration endeavors. Gioia is researching ways to grow fresh food for astronauts and there is a lot to learn about in this episode about plant science, challenges with crop production for space and more. Links:Growing Plants in Space - https://www.nasa.gov/content/growing-plants-in-spaceNASA’s International Space Station 20th Anniversary page - https://www.nasa.gov/station20

    • 28 min

Customer Reviews

5.0 out of 5
9 Ratings

9 Ratings

harvard_phdmylife ,

Great show

Love this show. From start to finish I can’t stop listening. Great questions and really interesting researcher stories.

zc-twist-bio ,

Love protocols!

So glad that there’s a podcast like this out there!!!!!

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