18 episodes

A series of films exploring research involving model organisms, and particularly the potential for studies on lower species to offer insights into human disease. These films centre around the question: can experiments on lower organisms contribute to the refinement, reduction, and replacement of animal use in biomedical research?

Model Organisms in Biomedical Research University of Leicester

    • Science
    • 1.0, 1 Rating

A series of films exploring research involving model organisms, and particularly the potential for studies on lower species to offer insights into human disease. These films centre around the question: can experiments on lower organisms contribute to the refinement, reduction, and replacement of animal use in biomedical research?

    • video
    Model Organisms in Biomedical Research SD

    Model Organisms in Biomedical Research SD

    Research to understand the working of the human body and to develop new medicines frequently involves the use of other species in preliminary experiments. For both ethical and economic reasons, scientists are committed -- as far as is possible -- to refining, reducing and replacing the use of higher animals in research. Using lower species, for example fruit flies and even yeast, as model organisms is an important part of that commitment.

    • 6 min
    • video
    Model Organisms in Biomedical Research HD

    Model Organisms in Biomedical Research HD

    Research to understand the working of the human body and to develop new medicines frequently involves the use of other species in preliminary experiments. For both ethical and economic reasons, scientists are committed -- as far as is possible -- to refining, reducing and replacing the use of higher animals in research. Using lower species, for example fruit flies and even yeast, as model organisms is an important part of that commitment.

    • 6 min
    • video
    The Power of Comparative Genomics HD

    The Power of Comparative Genomics HD

    Genomics is a branch of genetics in which large stretches of DNA, ideally the entire chromosome(s) of an organism are studied.
    As the complete series of DNA letters (bases) in the genomes of a growing number of organisms are worked out, it becomes possible to analyse these sequences side-by-side to look for similarities and differences. This method, known as genomics, can be a very powerful way to reveal information about the relationship between different species. It can also have surprising uses in medical research.
    In an example discussed in the video, a team led by Susan Dutcher from Washington University were able to find a previously unknown gene causing a human disease by comparing the human genome with the DNA of two different plant species. If you want to know how, watch the film!
    Comparative genomics can help to reduce the number of experiments being carried out with more complex species, such as mammals. Use of this approach is therefore making a valuable contribution to scientists' commitment to the 3Rs (the desire to reduce, refine and replace the use of higher animals in research).

    • 7 min
    • video
    The Power of Comparative Genomics SD

    The Power of Comparative Genomics SD

    Genomics is a branch of genetics in which large stretches of DNA, ideally the entire chromosome(s) of an organism are studied.
    As the complete series of DNA letters (bases) in the genomes of a growing number of organisms are worked out, it becomes possible to analyse these sequences side-by-side to look for similarities and differences. This method, known as genomics, can be a very powerful way to reveal information about the relationship between different species. It can also have surprising uses in medical research.
    In an example discussed in the video, a team led by Susan Dutcher from Washington University were able to find a previously unknown gene causing a human disease by comparing the human genome with the DNA of two different plant species. If you want to know how, watch the film!
    Comparative genomics can help to reduce the number of experiments being carried out with more complex species, such as mammals. Use of this approach is therefore making a valuable contribution to scientists' commitment to the 3Rs (the desire to reduce, refine and replace the use of higher animals in research).

    • 7 min
    • video
    Studying Huntington's Disease Using Model Organisms SD

    Studying Huntington's Disease Using Model Organisms SD

    Flaviano ("Flav") Giorgini is Lecturer in Mammalian Genetics in the Genetics Department at the University of Leicester, UK. His research focuses on understanding the molecular mechanisms that underlie neurodegenerative diseases such as Huntington's Disease, Alzheimer's Disease and Parkinson's Disease,.
    In this short film, Dr Giorgini explains how he and his research team use Baker's yeast Saccaromyces cerevisiae and the fruit fly Drosophila melanogaster as model organisms in the quest for understanding of what goes wrong at a cellular level in Huntington's Disease and how this knowledge can be used to develop novel therapeutic compounds.

    • 2 min
    • video
    Studying Huntington's Disease Using Model Organisms HD

    Studying Huntington's Disease Using Model Organisms HD

    Flaviano ("Flav") Giorgini is Lecturer in Mammalian Genetics in the Genetics Department at the University of Leicester, UK. His research focuses on understanding the molecular mechanisms that underlie neurodegenerative diseases such as Huntington's Disease, Alzheimer's Disease and Parkinson's Disease,.
    In this short film, Dr Giorgini explains how he and his research team use Baker's yeast Saccaromyces cerevisiae and the fruit fly Drosophila melanogaster as model organisms in the quest for understanding of what goes wrong at a cellular level in Huntington's Disease and how this knowledge can be used to develop novel therapeutic compounds.

    • 2 min

Customer Reviews

1.0 out of 5
1 Rating

1 Rating

Top Podcasts In Science

More by University of Leicester