212 episodes

This podcast's purpose is to bring together the field of neuroprosthetics / brain machine interfaces / brain implants in an understandable conversation about the current topics and breakthroughs. We hope to complement scientific papers on new neural research in an easy, digestable way. Innovators and professionals can share thoughts or ideas to facilitate 'idea sex' to make the field of brain implants a smaller and more personal space.

Neural Implant podcast - the people behind Brain-Machine Interface revolutions Ladan Jiracek

    • Health & Fitness
    • 4.7 • 15 Ratings

This podcast's purpose is to bring together the field of neuroprosthetics / brain machine interfaces / brain implants in an understandable conversation about the current topics and breakthroughs. We hope to complement scientific papers on new neural research in an easy, digestable way. Innovators and professionals can share thoughts or ideas to facilitate 'idea sex' to make the field of brain implants a smaller and more personal space.

    Jon Sakai on interacting with your target patients and the neural sleeve made by Cionic

    Jon Sakai on interacting with your target patients and the neural sleeve made by Cionic

    Jon Sakai is the Head of Commercialization at Cionic, a wearable neurostimulator sleeve for those with neuromuscular disease
    ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here***
    Top 3 Takeaways:
    "There isn't any individualized training that needs to happen. What needs to happen is the identification of which muscle groups need support and have those turned on and programmed in intensity appropriately." "We were able to improve door sub selection and inversion in more than 90% of our participants." "There's nothing like getting an appreciation for a problem like the acuity of a problem when you just watch someone for five minutes struggle with something that's probably unimaginable if it's a condition that you're not familiar with." 0:45 "Do you want to introduce yourself better than I just did?"
    2:45 "There are algorithms that go behind it and it can actually predict how you're walking. How does that work?"
    3:45 "Is there a learning process for the algorithms?"
    5:00 "Do you guys use hydrogels as well? And how do you have gels inside of your leggings?"
    5:45 Iris Biomedical ad sponsorship
    6:30 "What kind of improvement is there?"
    8:30 How can your algorithm predict the end of a walking cycle before it has started?
    9:15 What was it like getting FDA approval?
    9:45 What are the next steps for the company after raising your next round of funding?
    10:30 How is this going to be sold? In clinics, prescriptions, or normal retail?
    11:45 What is Head of Commercialization and how does one get that role?
    14:45 "You guys have been around for four years. What do the next four years look like?"
    16:30 "What are some big challenges that are facing?"
    17:30 "If you had unlimited funding, what would you do?"
    18:30 What is some career advice you have?
    22:45 " Is there anything that we didn't talk about that you wanted to mention?"

    • 23 min
    Hannah Claridge on helping small neurotech companies with R&D work at TTP

    Hannah Claridge on helping small neurotech companies with R&D work at TTP

    Hannah Claridge is the Head of Neurotechnology at TTP which is a consultancy that helps neurotech companies create the next generation of medical devices.
    ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here***
    Top 3 Takeaways:
    "I think consulting is really fantastic for the variety that it offers you. Not just in terms of seeing problems, but also working with different types of companies, different types of technologies, and having different day-to-day activities as well"
    "There have been cases where we've worked with very small companies where the company is composed of two or three founders whose sole role is the concept of the idea and the thinking behind what's the business case, and then gathering in the funding and passing that funding through for us to carry out the product development work. Now that's pretty unusual in most cases."
    "You need to be able to balance the efficacy of treatment with the side effects that are usually created. And if you go too far in one direction or the other, then that treatment stops being helpful. So if you stimulate too strongly, and the effect might be really effective but if the side effects are too strong, then patients aren't going to tolerate that." 0:45 Do you want to introduce yourself better than I just did?
    1:45 "Let's talk about clinical translation, what does that entail?"
    4:45 Iris Biomedical ad sponsorship
    5:45 "What's a typical contract length and what does it look like from beginning to end?"
    9:00 "It really sounds like you guys do everything. You could just take an idea and then bring it almost all the way to market"
    10:15 "Do you wanna share the neurotech projects you've worked on?"
    11:15 "What's a common problem that you see?"
    17:15 "How does a company recover, like from having so much help to not having any help? Is that typical too?"
    19:45 "What does your day-to-day look like? What are you usually doing?"
    22:30 What's a typical pathway into the career of consulting?
    25:15 "If you had unlimited funding or if a company had unlimited funding, what would you do?"
    28:00 "Is there anything that we didn't talk about that you wanted to mention?"

    • 28 min
    Lindsey Jardine talks all about clinical trials for neurotech

    Lindsey Jardine talks all about clinical trials for neurotech

    Lindsey Jardine is a clinical project manager at Boston Scientific which had acquired Farapulse, a cardiac ablation medical device company she was working in. She runs clinical trials for medtech companies and had done so for neurotech companies as well.
    ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here***
    Top 3 Takeaways:
    "One of the most difficult things that I've found while you're actually running the study, is making sure those devices are getting to the sites, which is depending on where your manufacturer is" Hiring a Contract Research Organization (CRO) or hiring clinical trial specialists in-house depends on what the plan for the company is, whether it will be acquired or do an IPO "My biggest problem with startups is wanting to do too much. Because if you're trying to develop eight things at once, you're not gonna get there and you're gonna run outta money. And that's how I see a lot of startups fail" 0:45 Do you want to introduce yourself better than I just did?
    1:15 "What is a clinical trial?"
    2:45 "How do medical devices maybe neurotechnology, compare to pharmaceuticals?"
    4:15 "What's a timeline?"
    6:00 "Where does the time get used up and then where does the money get used up?"
    8:45 Iris Biomedical ad sponsorship
    9:15 "Let's talk about budgets and how they vary, why they vary"
    11:30 "What does your day-to-day look like?"
    17:45 "How did you get into it?"
     21:45 What would be the formal path to get into clinical trials?
    26:15 "What's a common mistake for startups?"
    29:30 "Do the big guys have a speed advantage?"
    31:00 "Is there anything that we didn't talk about that, that you wanted to mention?"

    • 33 min
    Dan Brounstein on how closed loop Spinal Cord Stimulation has better efficacy at Saluda

    Dan Brounstein on how closed loop Spinal Cord Stimulation has better efficacy at Saluda

    Dan Brounstein is Chief Strategy Officer at Saluda Medical where he is using his 15 years of Spinal Chord Stimulator experience to help deliver closed-loop pain relief directly to the spinal cord.
    ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here***
    Top 3 Takeaways:
     "We're stimulating with milliamps and we're trying to measure in microvolts, and we always use the analogy trying to listen to a pin drop next to a shotgun shot" "There's a lot of literature on loss of efficacy? It's just a therapy issue. When you deliver open-loop therapies blind across a neural target, you're ultimately going to create, over-stimulation in a lot of times under stimulation. On top of that, over time things change"
    "Patients come in between four and five times a year on average in perpetuity with open loop systems" 0:45 " Do you want to introduce yourself and the company better than I just did?"
    6:00 "Your guys' device reprograms on its own? And then what signals does it take in and how does it change the stimulation patterns based on that?"
    9:00 Iris Biomedical ad sponsorship
    9:45 "What is your input and output for your guys' device?"
    11:45 "In February of 2023, you guys got FDA approval for this. Do you wanna talk a little bit about this?"
    14:15 "Is it like 5% better than open loop or is that something that's gonna be coming out published later?"
    17:00 "Is there another indication?"
    18:15 "The last I guess seven years for you has been very exciting. Is there anything on the horizon for the next seven years?"
    20:15 "You guys have 300 people and have raised 200 million. What's it like working in such a big company"
    22:45 "Is it getting too big for you?"
    23:45 "What advice do you have for people in your situation?"
    26:00 "Is there anything that we didn't talk about that you wanted to mention?"

    • 26 min
    Dr Angelique Johnson on starting a Medical Device Outsource Manufacturer, MEMStim

    Dr Angelique Johnson on starting a Medical Device Outsource Manufacturer, MEMStim

    Dr Angelique Johnson is the founder and CEO of MEMStim which is a leading global medical device outsource manufacturer (MDO) serving the neurostimulation market, based in Louisville, KY.
    ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here***
    Top 3 Takeaways:
    "Our true competitors are actually not microfab but actually hand assembly, manual assembly" "I'm an accidental entrepreneur- the more I pitched, the more I thought about the business idea, the more I talked to actual customers the more I realized like, Hey, there's actually a need and we actually have a pretty good revenue model for meeting that need." "Kentucky actually matches investment and grant dollars depending on where your grants come from." 0:45 "Do you wanna introduce yourself better than I did?"
    2:45 How did you make 3D cochlear device out of 2D microfabrication?
    4:40 "Tell me about the founding of MEMStim"
    8:00 Are you guys moving away from MEMS and towards 3D printing only?
    9:00 Is the future 3D printed soft materials?
    10:15 Iris Biomedical ad sponsorship
    11:00 "Who are your customers right now?"
    13:45 "What does the design process look like?"
    16:15 "Have you helped companies get through ISO certifications and FDA approvals?"
    18:30 "Do you guys do the implantable pulse generator or do you just do the electrodes?"
    21:00 "Are you guys also prepared to ramp that up into actual production?"
    22:45 "Do you have any advice for how you've survived for so long?
    29:45 "What are the last five years that looked like and what are the next five years look like?"
    31:00 "You're based in Kentucky, Louisville. Is there any reason for that?"
    33:15 "Is there anything that we didn't talk about that you wanted to mention?"
     

    • 34 min
    John Seymour on directional depth arrays and the future of neurosurgery

    John Seymour on directional depth arrays and the future of neurosurgery

    Dr John Seymour is an Associate Professor at UT Health in Neurosurgery and at Rice University where his lab works on electrophysiology studies, biophysics modeling, and applying machine learning models to decoding of neural activity. A major project in our lab is focused on developing a long-term brain-machine interface for the treatment of aphasia or locked-in syndrome.
    ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools here***
    Top 3 Takeaways:
    "Your job as the engineer is to create a high resolution map of a crowd's vocalization during some live event, the rules are, you only get the place, say 10 or 20 devices throughout the stadium but only on these devices. At some point you realize more and more microphones on these poles are going to generate redundant information and they won't help us in our challenge to map the vocalization of this massive stadium. People have a very good intuition for sounds and we all understand sound is directional. Neural signals act the same way." "A rough rule of thumb is if the substrate diameter is on the order of magnitude of the source size, then there is good directionality in that situation." One day neural devices will be based on the patient's anatomy and will be printed on-demand to match the patient 0:45 "Do you want to introduce yourself better than I just did?"
    2:45 "Geographically, how close are Rice and UT health?"
    3:15 "You're saying the future of neural implants is additive depth electrodes. What does that mean?"
    13:45 Sponsorship by Ripple Neuro
    14:15 "What's the solution, to try to make them directional?"
    16:30 "So you basically need your collector to be as small as possible?"
    18:30 "So by finding the right size of the electrode and the substrate diameter you're able to have directional electrodes?"
    22:45 "What's the advantage of your technology? What does it change?"
    28:00 " If you had unlimited funding, what would you be able to do with it?"
    33:00 What kind of differences of electrode design would you expect patient to patient?
    34:45 "These few years ago, you said you were at Rice before, exclusively, and then now moved to both UT Health and Rice. What's that been like?"
    42:00"Is there anything that we didn't talk about that you wanted to mention?"
     

    • 44 min

Customer Reviews

4.7 out of 5
15 Ratings

15 Ratings

Esaan A ,

Great and Informative Channel!

This channel provides wonderful in-depth perspectives to the developing field of neural technologies. I highly recommend the Dan Rizzuto episode—really made me ponder the possibilities for patients suffering from traumatic brain injury. Awesome job!

Dubuel ,

Best source of neural interface and brain implant info on the web today

Ladan is an amazing podcaster who has managed to snag some of the best and most important people in this space and ask great questions for 30+ minutes at a time. Very on topic, insightful, and I've learned so many things about companies and research that I could not have anywhere else. If you're into brain-computer interfaces, this is perhaps THE most information-dense way to learn.

PotyPotato ,

Helpful and insightful

I really enjoy the different guests in this podcast. I'm a 1st year engineering student and just started as a research student assistant at my university. I still have not gotten to the upper level courses so I feel rather behind in terms of knowledge during lab meetings, but this podcasts helps me shorten that gap between what I know and want to know in terms of neuroprostheses. Definitely recommend!

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