31 episodes

BrainPod is the podcast from the journal Neuropsychopharmacology, produced in association with Nature Publishing Group. Join us as we delve into the latest basic and clinical research that advance our understanding of the brain and behavior, featuring highlighted content from a top journal in fields of neuroscience, psychiatry, and pharmacology. For complete access to the original papers and reviews featured in this podcast, subscribe to Neuropsychopharmacology.

Neuropsychopharmacology Podcast Nature

    • Science
    • 3.8 • 12 Ratings

BrainPod is the podcast from the journal Neuropsychopharmacology, produced in association with Nature Publishing Group. Join us as we delve into the latest basic and clinical research that advance our understanding of the brain and behavior, featuring highlighted content from a top journal in fields of neuroscience, psychiatry, and pharmacology. For complete access to the original papers and reviews featured in this podcast, subscribe to Neuropsychopharmacology.

    Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders

    Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders

    The application of the study of genetics and the use of big data to identify patterns of inheritance as well as de novo mutations has had a dramatic impact on the field of Autism Spectrum Disorder research, and it offers pathways to a greater understanding of biological mechanisms, even potentially treatments. Matthew State, chair of the department of psychiatry at University of California San Francisco, and his colleagues wrote a review paper in the journal Neuropsychopharmacology, called “Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders.” Have a listen to learn more!
     
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    • 9 min
    Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain

    Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain

    It’s understood in epidemiological research that women who experience trauma during puberty are at significantly higher risk for affective disorders such as depression and anxiety when they become pregnant. And so Tracy Bale, a professor in the departments of psychology and psychiatry at the University of Maryland in Baltimore, has done several studies using mice to try to model and understand this effect. In her latest paper in the journal Neuropsychopharmacology, she and her colleagues set out to study just what was happening to make the mouse brain so vulnerable to stress and trauma during puberty, and how this was activated during the hormonal onslaught of pregnancy.
     
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    • 9 min
    Social networking and mental health: looking beyond frequency of use and towards mechanisms of action

    Social networking and mental health: looking beyond frequency of use and towards mechanisms of action

    Over the past decades, there’s clearly been a dramatic increase in the amount of time people spend online using social networking sites. For instance, Facebook and Instagram have literally billions of users. At the same time, there’s been a rise in mental health issues for young people from teens through their mid 20s. The rise in these issues has been seen particularly for Millennials and the I generation, both of which grew up with increased access to and use of social networking sites. As a result, some have drawn the conclusion that perhaps the two are linked, and the rise in mental health issues is linked causally to the increase in time spent online, and so treatment should involve reducing social networking use. Dr. Kiara Timpano, associate professor at the University of Miami department of psychology, and Dr. Courtney Beard, co-director of the clinical research program in behavioral health at McLean Hospital and associate professor of psychiatry at Harvard Medical School, reviewed the literature.
     
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    • 9 min
    Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects

    Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects

    A number of drugs that are used recreationally are now being studied for their use in psychopharmacology. But while the ways in which these drugs are similar or different has been described anecdotally by recreational users, they haven’t been studied in comparison to one another. Dr. Matthias Liechti and his team of researchers recently published a study in the journal Neuropsychopharmacology, in which 28 healthy subjects, men and women, take doses of LSD, MDMA, amphetamines, and a placebo over four different sessions. Dr. Liechti says this blinding is important; in other studies, participants either have taken a drug or a placebo and can tell when they’re taking the drug. But in this case they don’t know which drug they’re taking, which allows the effects of the drugs to be compared against each other. Take a listen to find out more!
     
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    • 9 min
    Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma

    Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma

    It’s known that there’s a relationship between post-traumatic stress disorder, or PTSD, and a higher rate of opioid abuse. What isn’t understood, though, is what that relationship is. Does PTSD cause people to turn to opioids in particular among all the potential drugs of abuse, or is there something about opioid use that makes users particularly sensitive to trauma?


    This is just what Michael Fanselow, professor in the psychology and psychiatry departments at UCLA, and his colleagues investigated for a recent study in the journal Neuropsychopharmacology.
     
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    • 9 min
    Effects of MDMA on attention to positive social cues and pleasantness of affective touch.

    Effects of MDMA on attention to positive social cues and pleasantness of affective touch.

    The recreational drug MDMA, also known as Ecstasy or Molly, is particularly popular in social settings and raves, in large part because of how socially connected it makes the users feel. It's being studied for use in psychotherapy — there's a phase III clinical trial for the use of MDMA to treat PTSD. What's clear is that the drug affects how users experience social interactions. But there are questions: Does the drug make positive social interactions feel better, or reduce the negative feelings associated with negative social interactions?
     
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    • 9 min

Customer Reviews

3.8 out of 5
12 Ratings

12 Ratings

brainzmatter ,

Robot vs Valley Girl

What’s with the host’s robotic voice? She cannot be a real person. The I am to take seriously an interviewee who has all the gravitas of a cheerleader. Dull is putting it too kindly.

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