Nutritional Medicine Podcast

Benjamin Brown
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The Nutritional Medicine Podcast is the official podcast of the Nutritional Medicine Institute (NMI), an educational, advocacy and research group committed to advancing the science and practice of nutritional medicine. The podcast features interviews with leading scientists, clinicians and advocates of nutritional medicine, including integrative, functional and lifestyle medicine-based approaches. Expert interviews are focused on the role of diet and nutrition, environment, behaviour and lifestyle as determinants of health. We explore science that informs the application of personalised lifestyle, dietary interventions and nutrient-based supplements in clinical practice. Your host is Benjamin Brown, Director of the Nutritional Medicine Institute and expert in personalised nutrition and lifestyle medicine. The contents of the NMI Podcast are for educational purposes and intended for health professionals. This information is not a substitution for standard medical care. Health professionals are solely responsible for the care and treatment provided to their own patients.

  1. Dr. Alex Richardson: Pioneering Clinical Research into Food and Mental Health

    MAR 27

    Dr. Alex Richardson: Pioneering Clinical Research into Food and Mental Health

    This remarkable conversation with Dr. Alex Richardson covers the development of her research that was some of the first to demonstrate the influence of food and nutrition on mood and behaviour. Dr. Richardson has been hugely influential in putting nutrition for mental health on the map, especially in areas such as dyslexia, dyspraxia, ADHD, depression and schizophrenia. From genetics, biochemistry, and nutrition to physiological and psychological functioning, we explore diverse themes relevant to everyone.    About our guest:    Dr Alex Richardson is a world-renowned researcher, educator, speaker and published author; and the Founder Trustee and Scientific Director of the UK-based charity, Food and Behaviour (FAB) Research. Based at the University of Oxford for 30 years, the impact of her 90+ peer-reviewed publications places Dr Richardson in the top 3% of academic researchers worldwide.   In addition to her work for FAB, she is currently a Visiting Research Fellow at the University of Bournemouth, Research Consultant for the Centre of Nutrition and Behaviour at the Rotherham, Doncaster and South Humberside NHS Trust, and research collaborator with the Dept of Psychology at the University of Swansea.   Alex is best known for her research into how nutrition (particularly fatty acids) can affect behaviour, learning and mood, as her pioneering clinical trials were the first to show that dietary supplementation with omega-3 (and omega-6) fats can improve behaviour and learning in children with dyslexia, dyspraxia, ADHD and related conditions; and that this approach may also help many other children without such diagnoses. She also published some of the earliest reports of successful nutritional approaches to both depression and schizophrenia in young adults, which have subsequently been confirmed and extended by others.   Her work has always been highly inter-disciplinary and collaborative, involving several large-scale collaborative programmes that include studies of epidemiology, genetics, brain imaging, biochemistry and nutrition as well as physiological and psychological functioning.  Her main interests centre on the role of nutrition in brain health, and its implications for behaviour, learning and mood, particularly in relation to: neurodevelopment, mental health, links between mental and physical health.   Alex's research has also always been primarily aimed at developing new methods of identification and management that will have real practical benefit.   In addition to her role as a founder director of FAB Research, she also helped to found the Dyslexia Research Trust, was a co-opted Trustee and Scientific Advisor to the Dyspraxia Foundation, served on the Biomedical Research Committee of Autism Unravelled, and liaised closely with the Hyperactive Children's Support Group, among many others.   Guest websites and links:   https://www.fabresearch.org   Selection of our guest's publications:   Montgomery P, Burton JR, Sewell RP, Spreckelsen TF, Richardson AJ. Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. J Sleep Res. 2014 Aug;23(4):364-88. Richardson AJ, Burton JR, Sewell RP, Spreckelsen TF, Montgomery P. Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). PLoS One. 2012;7(9):e43909.  Richardson A. They Are What You Feed Them: How Food Can Improve Your Child's Behaviour, Learning and Mood. Harper. 2010. Cyhlarova E, Montgomery P, Ross MA, Richardson AJ. Niacin skin test response in dyslexia. Prostaglandins Leukot Essent Fatty Acids. 2007 Aug;77(2):123-8.  Richardson AJ, Puri BK. A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):233-9.

    1h 17m
  2. Dr. James Greenblatt: Depression; A Functional Medicine Approach Focusing on Underlying Causes

    FEB 25

    Dr. James Greenblatt: Depression; A Functional Medicine Approach Focusing on Underlying Causes

    For over 30-years, Dr Greenblatt has been practicing, researching and educating health providers on the role of personalised nutrition in psychiatry and remains at the forefront of this important area. His new book Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression is a landmark contribution and will transform people's lives while highlighting the power of personalised, evidence-based nutrition practice to improve mental health care.    Guest:  Dr. James Greenblatt   About our guest:  James Greenblatt, MD, is a globally recognized pioneer in functional and integrative psychiatry with over 30 years of clinical experience. He has dedicated his career to transforming the treatment of mental health disorders through precision-based approaches that integrate laboratory testing, nutritional interventions, and root-cause analysis. Dr. Greenblatt earned his medical degree and completed a psychiatry residency at George Washington University, and pursued a Child and Adolescent Psychiatry fellowship at Johns Hopkins Medical School. A prolific author, Dr. Greenblatt has written nine books, including his newest title, Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression, and the bestseller Finally Focused: The Breakthrough Natural Treatment Plan for ADHD. He serves as an Assistant Clinical Professor of Psychiatry at Tufts University School of Medicine and Dartmouth College's Geisel School of Medicine. Previously, he served as Chief Medical Officer for Walden Behavioral Care/Monte Nido, a national mental health organization  specializing in eating disorders. In 2019, Dr. Greenblatt founded Psychiatry Redefined, a leading platform for continuing education for clinicians in functional and integrative psychiatry, designed to bridge critical knowledge gaps for mental health professionals.   Guest websites and links: https://www.jamesgreenblattmd.com https://www.psychiatryredefined.org/   Selection of our guest's publications: Greenblatt J, Gottlieb B. Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression. Penguin Random House. 2026.  Greenblatt J, Dimino JC. Functional Medicine for Antidepressant Withdrawal. FriesenPress. 2022.  Greenblatt J. Finally Focused: The Breakthrough Natural Treatment Plan for ADHD.  Harmony. 2017.

    32 min
  3. Dr. Miguel Toribio-Mateas: Navigating Nutrition Misinformation with Context, Nuance and Compassion

    JAN 30

    Dr. Miguel Toribio-Mateas: Navigating Nutrition Misinformation with Context, Nuance and Compassion

    Dr Miguel is a remarkable scientist in that he gracefully bridges the worlds of research, education, clinical practice, public outreach and compassion in his work. This interview explores topics relevant to the translation of science to real world relevance in an authentic, compassionate and humanistic way. We also explore his new book ADHD Body and Mind: A Compassionate Guide to Rewilding Your Nervous System with Neuroscience, Nutrition, and Gut-Brain Health. Guest:   Dr. Miguel Toribio-Mateas   About our guest:   Dr. Miguel Toribio-Mateas is a clinical neuroscientist, applied microbiologist, and nutritionist with over 25 years of experience in healthcare, science, and technology. His research explores the microbiota-gut-brain axis, investigating how diet and lifestyle influence mood, cognition, and behaviour. With a doctorate in gut microbiome and mental health, his work has earned recognition, including the prestigious Santander Universities Work-Based Learning Award in 2016 and publication in peer-reviewed journals like the BMJ.   Dr. Miguel has led transdisciplinary research projects, designing and overseeing clinical trials that examine the role of nutrition in psychiatric and neurodevelopmental conditions. He previously held a five-year research fellowship at London South Bank University, focusing on gut health's impact on cognitive function and mental wellbeing. Currently, he is part of a multi-centre team evaluating natural approaches to ADHD management and holds an Honorary Research Fellowship at Cardiff University's School of Psychology. Alongside his research, he is a lecturer in nutrition at the University of West London, where his work focuses on quality improvement in public health interventions and their interface with gut and brain health.   He is has a self-compassionate guide to the neuroscience of ADHD, which will be published in April 2026 by Jessica Kingsley Publishers. Through his research, teaching, and writing, Dr. Miguel empowers individuals to make informed, evidence-based dietary choices that nurture both body and mind—always with the understanding that self-care is not about perfection, but about kindness and adaptability.   Guest websites and links: https://drmiguelmateas.com https://www.instagram.com/drmiguelmateas Selection of our guest's publications: Toribio-Mateas M. ADHD Body and Mind: A Compassionate Guide to Rewilding Your Nervous System with Neuroscience, Nutrition, and Gut-Brain Health. ‎Jessica Kingsley Publishers. 2026. Lawrence K, Fibert P, Toribio-Mateas M, Gregory AM, Hobbs J, Quadt F, Wright S, Cotter PD, Patel S, Myrissa K. Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD: a randomised controlled trial. BMC Psychiatry. 2025 Nov 24;25(1):1117.  Toribio-Mateas M, Noble G. Making Room for Every Voice: Reimagining Person-Centred Care in the Neurosciences. Health Expect. 2025 Aug;28(4):e70350.  Lawrence K, Fibert P, Hobbs J, Myrissa K, Toribio-Mateas MA, Quadt F, Cotter PD, Gregory AM. Randomised controlled trial of the effects of kefir on behaviour, sleep and the microbiome in children with ADHD: a study protocol. BMJ Open. 2023 Dec 7;13(12):e071063.  Toribio-Mateas MA, Bester A, Klimenko N. Impact of Plant-Based Meat Alternatives on the Gut Microbiota of Consumers: A Real-World Study. Foods. 2021 Aug 30;10(9):2040.  Shevlyakov A, Nikogosov D, Stewart LA, Toribio-Mateas M. Reference values for intake of six types of soluble and insoluble fibre in healthy UK inhabitants based on the UK Biobank data. Public Health Nutr. 2021 Jun 9:1-15.  Toribio-Mateas M. Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions. Microorganisms. 2018 Apr 25;6(2):35.

    1h 13m
  4. Dr. Alan Gaby: Nutritional Medicine; Important Treatments that are Overlooked or Ignored

    12/15/2025

    Dr. Alan Gaby: Nutritional Medicine; Important Treatments that are Overlooked or Ignored

    Who literally wrote the book on nutritional medicine? Dr Alan Gaby. In this interview, Dr Gaby talks about his pioneering work that ultimately resulted in the publication of what is arguably the most important reference text in the field: Nutritional Medicine, Third Edition 2023. In addition, he discusses explore nutritional therapies that are clinically very useful but broadly overlooked including potassium magnesium aspartate for fatigue, riboflavin for migraine prevention and identifying hidden food allergies for treating various conditions. Guest:  Dr. Alan Gaby, MD  About our guest:  Dr. Gaby received his undergraduate degree from Yale University, his M.S. in biochemistry from Emory University, and his M.D. from the University of Maryland. He was in private practice for 19 years, specializing in nutritional medicine. He is past-president of the American Holistic Medical Association and has given expert testimony to the White House Commission on Complementary and Alternative Medicine on the cost-effectiveness of nutritional supplements. He is the author of Preventing and Reversing Osteoporosis (Prima, 1994) and The Doctor's Guide to Vitamin B6 (Rodale Press, 1984), and is co-author of The Patient's Book of Natural Healing (Prima, 1999). Dr. Gaby has written numerous scientific papers in the field of nutritional medicine. He was the contributing medical editor for the Townsend Letter for Doctors from 1985 to 2023 and was contributing editor for Alternative Medicine Review from 1996 to 2010. Over the past 43 years, Dr. Gaby has developed a computerized database of more than 28,000 individually chosen medical journal articles related to the field of natural medicine. He was professor of nutrition and a member of the clinical faculty at Bastyr University in Kenmore, WA, from 1995 to 2002. In 2010, Dr. Gaby completed a 30-year project: the textbook Nutritional Medicine. The second edition of Nutritional Medicine was completed in 2017 and the updated third edition was completed in 2023.  Nutritional Medicine by Dr. Alan R. Gaby is a science-based, extensively referenced textbook written for healthcare practitioners and for non-practitioners who are interested in viable alternatives to conventional medicine. The textbook discusses hundreds of nutritional therapies that can be used as effective, low-cost, low-risk alternatives or adjuncts to conventional medicine. Guest websites and links: https://doctorgaby.com Selection of our guest's publications: Gaby AR. Nutritional Medicine, Third Edition. Fritz Perlberg Publishing. 2023. Gaby AR. Is There an Epidemic of Research Fraud in Natural Medicine? Integr Med (Encinitas). 2022 May;21(2):14-18. Gaby AR. Adverse effects of dietary fructose. Altern Med Rev. 2005 Dec;10(4):294-306. Gaby AR. The role of hidden food allergy/intolerance in chronic disease. Altern Med Rev. 1998 Apr;3(2):90-100.  Editor's note: Connection was lost during the interview in two places. The reference to a vitamin for arthritis referred to niacinamide (see Osteoarthritis page 699, in Gaby A, Nutritional Medicine, Third Edition 2023).

    50 min
  5. Dr. Ryan Bradley: Transforming Cardiometabolic Health with Personalised Lifestyle Medicine

    11/18/2025

    Dr. Ryan Bradley: Transforming Cardiometabolic Health with Personalised Lifestyle Medicine

    Cardiometabolic disorders are the leading cause of morbidity and mortality yet can largely be prevented with diet and lifestyle medicine. Why is there a gap between this epidemic and more effective treatment? Dr. Bradley discusses his clinical research on feasible, cost-effective, efficacious interventions and wider topics around personalised whole person care and 'disruptive innovation' for health promotion.   Guest:  Dr. Ryan Bradley, ND, MPH   About our guest:   Dr. Bradley is an Associate Professor in the University of California, San Diego Herbert Wertheim School of Public Health and Human Longevity Science in La Jolla, CA. His commitment to research is to improve the health of the public through rigorous research on non-drug treatments.    Dr. Bradley received his ND in naturopathic medicine from Bastyr University in 2003, and his MPH in Epidemiology from the University of Washington in 2009. He completed NIH-funded T32 research training in complementary medicine at Bastyr University and KL2 training in clinical research at the University of Washington in the Division of Cardiology.    His research interests include clinical trials of natural products and mind-body therapies in chronic inflammatory conditions including heart disease, type 2 diabetes, pain, and inflammatory bowel disease, plus cardiovascular epidemiology related to natural products, e.g., cannabis, and heart disease risk.   Dr. Bradley has conducted a wide-variety of clinical and observational research, including: cardiovascular epidemiology in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort; observational research and clinical trials on practice outcomes from integrating naturopathic medicine and conventional medicine for type 2 diabetes and cardiovascular disease; clinical trials of natural products (including vitamin D, marine oils, xanthohumol, mixed-carotenoids, and quercetin) and mind-body interventions including qigong for type 2 diabetes.    He has published in leading peer-reviewed medical journals including: Journal of Alzheimer's Disease, Aging, Atherosclerosis, the Canadian Medical Association Journal, and the Journal of Clinical Endocrinology and Metabolism.   Guest websites and links: https://www.researchgate.net/profile/Ryan-Bradley-7 Selection of our guest's publications: Harnett JE, Rickwood C, Steel A, Bradley R. Naturopathic practitioners' approach to caring for people with cardiovascular disease risk factors: A cross-cultural cross-sectional study reporting the providers perspective. Complement Ther Clin Pract. 2022 Feb;46:101511. Anderson CAM, Bradley R. The potential of novel plant protein foods to improve dietary patterns and markers of cardiovascular health. Am J Clin Nutr. 2020 Nov 11;112(5):1151-1152. Steel A, Rickwood C, Bradley R, Foley H, Harnett JE. Australian Naturopaths' Approach to Caring for People with Cardiovascular Disease and Associated Risk Factors: A Qualitative Study of the Providers' Perspective. J Altern Complement Med. 2020 Oct;26(10):902-910. Bradley R, Harnett J, Cooley K, McIntyre E, Goldenberg J, Adams J. Naturopathy as a Model of Prevention-Oriented, Patient-Centred Primary Care: A Disruptive Innovation in Health Care. Medicina (Kaunas). 2019 Sep 18;55(9):603. doi: 10.3390/medicina55090603. PMID: 31540415; PMCID: PMC6780388. Seely D, Szczurko O, Cooley K, Fritz H, Aberdour S, Herrington C, Herman P, Rouchotas P, Lescheid D, Bradley R, Gignac T, Bernhardt B, Zhou Q, Guyatt G. Naturopathic medicine for the prevention of cardiovascular disease: a randomized clinical trial. CMAJ. 2013 Jun 11;185(9):E409-16. Neuendorf R, Corn J, Hanes D, Bradley R. Impact of Food Immunoglobulin G-Based Elimination Diet on Subsequent Food Immunoglobulin G and Quality of Life in Overweight/Obese Adults. J Altern Complement Med. 2019 Feb;25(2):241-248. Bradley R, Sherman KJ, Catz S, Calabrese C, Oberg EB, Jordan L, Grothaus L, Cherkin D. Adjunctive naturopathic care for type 2 diabetes: patient-reported and clinical outcomes after one year. BMC Complement Altern Med. 2012 Apr 18;12:44. doi: 10.1186/1472-6882-12-44.

    58 min
  6. Professor Joseph Firth: Improving Mental Health Outcomes with Nutrition and Lifestyle Medicine

    10/14/2025

    Professor Joseph Firth: Improving Mental Health Outcomes with Nutrition and Lifestyle Medicine

    The concepts of 'lifestyle psychiatry,' and 'nutritional psychiatry' are transforming the way we think about mental health and wellbeing. Professor Joseph Firth shares his influential work in this area and its implications for changing clinical practice and health policy. We also discuss the digital environment as a newly evolving lifestyle factor that influences mental health.   About our guest:   Dr. Firth is Professor of Psychology & Mental Health, University of Manchester, Manchester, U.K, with a PhD (Medicine) from The University of Manchester.   Internationally recognized as one of the most highly-cited scientists in Digital Medicine, Lifestyle Psychiatry and Mental Health, he was awarded the USERN Laureate in Social Sciences in 2022 and named Research.com's #1 "Rising Star" in 2023.   A five-time recipient of the Clarivate™ Highly Cited Researcher award (2020–2024), he has published over 300 articles with more than 45,000 citations (h-index = 90), including first-author papers in top journals like The BMJ and The Lancet Psychiatry.   His current research leverages digital technologies and lifestyle medicine to improve outcomes for people with mental illness, and he is currently leading a multi-million £ UKRI-funded project around the implementation of digital lifestyle interventions into youth mental healthcare.   Dr. Firth also leads the Lancet Commission on Physical Health in Mental Illness, and acts as expert advisor for the World Health Organization's "Guidelines on Physical Activity and Sedentary Behaviour".   He has also engaged extensively with traditional and online media, with his publications around lifestyle and nutritional approaches to mental illness receiving coverage from >700 news outlets (including Times, Forbes, CNN, etc.) along with televised interviews on Sky News and BBC television.   Guest websites and links:   https://research.manchester.ac.uk/en/persons/joseph.firth   Selection of our guest's publications: Brinsley J, O'Connor EJ, Singh B, et al. Effectiveness of Digital Lifestyle Interventions on Depression, Anxiety, Stress, and Well-Being: Systematic Review and Meta-Analysis. J Med Internet Res. 2025 Mar 20;27:e56975. Marx W, Lane M, Hockey M, et al. Diet and depression: exploring the biological mechanisms of action. Mol Psychiatry. 2021 Jan;26(1):134-150. Firth J, Gangwisch JE, Borisini A, Wootton RE, Mayer EA. Food and mood: how do diet and nutrition affect mental wellbeing? BMJ. 2020 Jun 29;369:m2382. Firth J, Solmi M, Wootton RE, et al. A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders. World Psychiatry. 2020 Oct;19(3):360-380. Firth J, Teasdale SB, Allott K, et al. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials. World Psychiatry. 2019 Oct;18(3):308-324. Firth J, Marx W, Dash S, et al. The Effects of Dietary Improvement on Symptoms of Depression and Anxiety: A Meta-Analysis of Randomized Controlled Trials. Psychosom Med. 2019 Apr;81(3):265-280. Firth J, Veronese N, Cotter J, et al. What Is the Role of Dietary Inflammation in Severe Mental Illness? A Review of Observational and Experimental Findings. Front Psychiatry. 2019 May 15;10:350. Firth J, Stubbs B, Sarris J, et al. The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis. Psychol Med. 2017 Jul;47(9):1515-1527.

    42 min
  7. Dr Adrian Lopresti: Mental Health, Evidence-Based Nutraceuticals and Personalised Integrative Therapy

    10/14/2025

    Dr Adrian Lopresti: Mental Health, Evidence-Based Nutraceuticals and Personalised Integrative Therapy

    Dr Adrian Lopresti shares important clinical insights from his published research on natural products such as saffron, ashwagandha, curcumin and magnesium on anxiety, depression and insomnia. He also discusses personalised Integrative therapy, a holistic treatment model he has pioneered that places the use of natural products in the wider context of lifestyle medicine and nutritional psychiatry.    About our guest:    Dr Adrian Lopresti is the managing director at Clinical Research Australia, a clinical psychologist, and an adjunct senior lecturer at Murdoch University, Western Australia.    He regularly publishes in peer-reviewed, high-impact journals and has completed more than 50 clinical trials investigating the effects of ingredients such as saffron, ashwagandha, curcumin, lutein, bacopa monnieri, magnesium, probiotics, and holy basil on anxiety, depression, insomnia, cognitive decline, osteoarthritis, digestive conditions, and general wellbeing in children and adults.    Dr Lopresti also has over 25 years of clinical experience working with children and adults experiencing a range of mental health conditions and has extensive experience in utilising psychological, nutritional and lifestyle treatments.    Dr Lopresti is also the founder of Personalised Integrative Therapy, a holistic treatment for depression and anxiety, and regularly conducts workshops both nationally and internationally.   Guest websites and links:   https://clinicalresearch.com.au https://pitherapy.com.au   Selection of our guest's publications: Schuster J, Cycelskij I, Lopresti A, Hahn A. Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial. Nat Sci Sleep. 2025 Aug 30;17:2027-2040. Lopresti AL, Smith SJ, Metse AP, Drummond PD. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020 Jun 15;16(6):937-947. Smith SJ, Lopresti AL, Fairchild TJ. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. 2023 Nov;37(11):1091-1104. Lopresti AL, Smith SJ, Metse AP, Foster T, Drummond PD. The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20937997. Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. World J Biol Psychiatry. 2022 Jul;23(6):424-455. Lopresti AL. The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects? Adv Nutr. 2018 Jan 1;9(1):41-50. Lopresti AL, Maker GL, Hood SD, Drummond PD. A review of peripheral biomarkers in major depression: the potential of inflammatory and oxidative stress biomarkers. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:102-11.

    49 min
  8. Dr. Iain P. Hargreaves: CoQ10, Mitochondrial Dysfunction, Deficiency Diseases and Clinical Considerations

    09/22/2025

    Dr. Iain P. Hargreaves: CoQ10, Mitochondrial Dysfunction, Deficiency Diseases and Clinical Considerations

    Coenzyme Q10 has established use across both primary and secondary deficiency diseases. In this episode, Dr. Iain P. Hargreaves, PhD, an eminent scientist working on CoQ10, walks us through its history, functions, his work looking at blood brain barrier transport, clinical considerations around testing and supplementation, and where research is going in the future.   About our guest:   Dr. Iain P. Hargreaves, PhD is Senior Lecturer in Clinical Biochemistry / Honorary Consultant Clinical Scientist at the Neurometabolic Unit, National Hospital, Queen Square, London, UK School of Pharmacy, Liverpool John Moores University, Liverpool, UK.   Following his completion of a PhD in biochemistry at Liverpool University, UK he worked for Prof. Simon Heales and Dr. John Land at the Institute of Neurology, University College of London, London, UK where he was involved in the establishment of the Neurometabolic Unit which specialises in the diagnosis of metabolic disease, especially mitochondrial and neurotransmitter disorders.   Dr Hargreaves worked in the Neurometabolic Unit for 21 years until he left to take up a lecturing position in biochemistry/clinical biochemistry at Liverpool John Moores University, Liverpool, UK. Dr Hargreaves has retained an honorary consultant clinical scientist and senior lecturer position within the Neurometabolic Unit and Institute of Neurology, respectively and is still actively involved in the mitochondrial diagnostic service.   Dr Hargreaves is editor of Coenzyme Q10: From Fact to Fiction (2015), Mitochondrial Respiratory Chain Disorders: From Clinical Presentation to Diagnosis and Treatment (2019) and author of 160 peer-review research papers.   Guest websites and links:   https://www.researchgate.net/profile/Iain-Hargreaves   Selection of our guest's publications: Mantle D, Dewsbury M, Hargreaves IP. The Ubiquinone-Ubiquinol Redox Cycle and Its Clinical Consequences: An Overview. Int J Mol Sci. 2024 Jun 20;25(12):6765. Mantle D, Hargreaves IP, Domingo JC, Castro-Marrero J. Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview. Int J Mol Sci. 2024 Jan 1;25(1):574. Mantle D, Hargreaves I. Coenzyme Q10 and the Blood-Brain Barrier: An Overview. J Clin Med. 2025 Apr 16;14(8):2748. Staiano C, García-Corzo L, Mantle D, Turton N, Millichap LE, Brea-Calvo G, Hargreaves I. Biosynthesis, Deficiency, and Supplementation of Coenzyme Q. Antioxidants (Basel). 2023 Jul 21;12(7):1469. Mantle D, Heaton RA, Hargreaves IP. Coenzyme Q10, Ageing and the Nervous System: An Overview. Antioxidants (Basel). 2021 Dec 21;11(1):2.

    50 min
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About

The Nutritional Medicine Podcast is the official podcast of the Nutritional Medicine Institute (NMI), an educational, advocacy and research group committed to advancing the science and practice of nutritional medicine. The podcast features interviews with leading scientists, clinicians and advocates of nutritional medicine, including integrative, functional and lifestyle medicine-based approaches. Expert interviews are focused on the role of diet and nutrition, environment, behaviour and lifestyle as determinants of health. We explore science that informs the application of personalised lifestyle, dietary interventions and nutrient-based supplements in clinical practice. Your host is Benjamin Brown, Director of the Nutritional Medicine Institute and expert in personalised nutrition and lifestyle medicine. The contents of the NMI Podcast are for educational purposes and intended for health professionals. This information is not a substitution for standard medical care. Health professionals are solely responsible for the care and treatment provided to their own patients.

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