Sputnik spat and furin in ferrets This Week in Virology

TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode ASV vaccine town halls Brazil rejects Gamaleya vaccine (Sci Transl Med) Russian vaccine behavior (Sci Transl Med) Is Gamaleya vaccine safe? (Science) Furin cleavage site in replication and transmission (Nat Micro) Furin site loss attenuates pathogenesis (Nature) Timestamps by Jolene. Thanks! Weekly Picks Rich – The diversity and function of sourdough starter microbiomes; Dunn Lab Wild Sourdough Project
Kathy – ISS, Crew Dragon, and the sun  Doubly warped world of binary black holes
Vincent – Mr. Labman
Listener Picks Joy – Abandoned America: Matthew Christopher’s Autopsy of the American Dream
Intro music is by Ronald Jenkees

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