Pharmacology is one of the most challenge topics you will encounter as a healthcare professional, but it can be the most rewarding with a good understanding. Whether you are preparing to be a nurse, physician, physician assistant, pharmacist, dentist, nurse practitioner, pharmacy technician, pharmacologist, or other healthcare professional, this podcast will help you better understand pharmacology. In addition to giving you the basics like mechanism of action, side effects, drug interactions, etc., you will also be exposed to how medications actually impact patients in real life. In the Real Life Pharmacology podcast, Eric Christianson, PharmD shares his real world experiences about how a medication's mechanism of action, pharmacokinetics, adverse effects, and drug interactions can actually impact patients in both a positive and a potentially negative way. Eric Christianson PharmD is the author of the popular clinical pharmacy blog Meded101.com. People who are passionate about nursing, medicine, or pharmacy will find this podcast beneficial in helping them prepare for passing exams. This podcast is for educational purposes only and is not medical advice or intended to be a substitute for medical advice. Please seek advice from your pharmacist or primary care provider if you have questions about medications that you are taking.
Dutasteride (Avodart) Pharmacology Podcast
Dutasteride (Avodart) is a 5-alpha-reductase inhibitor. I discuss the pharmacology, adverse effects, and drug interactions on this podcast.
Dutasteride reduces the size of the prostate over time. It takes a significant amount of time to provide symptom relief (usually at least 3-6 months).
Dutasteride is broken down by CYP3A4 to a minor extent which means that strong CYP3A4 inhibitors may increase drug concentrations.
When using dutasteride for BPH, remember to review the medication list for drugs that can cause urinary retention such as anticholintiercs and alpha-agonists.
Prazosin (Minipress) Pharmacology Podcast
On this episode, I discuss prazosin pharmacology, adverse effects, drug interactions and much more.
Prazosin is an alpha-blocker but lacks selectivity. A reduction in blood pressure is expected, but it is notorious for causing orthostatic hypotension.
Prazosin may be used off-label for nightmares, when this is the case, you will likely only see this drug dosed at bedtime.
Alpha agonist medications (such as pseudoephedrine and ADHD stimulants) may counteract the effects of prazosin.
Tirzepatide (Mounjaro) Pharmacology Podcast
On this episode I discuss the pharmacology of tirzepatide. I'm appreciative of Derek Borkowski who operates Pyrls for providing a free PDF of the 2023 ADA Diabetes Guidelines when you subscribe for an account at Pyrls.com/rlp - Tirzepatide makes its first appearance in the diabetes guidelines for its ability to promote weight loss.
Tirzepatide is a combination GIP and GLP-1 agonist that is currently indicated for diabetes with reductions of A1C in the range of about 2 points.
Much like GLP-1 agonists, tirzepatide can cause GI upset and other gastrointestinal adverse effects like diarrhea.
Tirzepatide doesn't have a large number of drug interactions which is nice. Corticosteroids can counteract its blood sugar-lowering effects while sulfonylureas and insulin may significantly increase the risk for hypoglycemia.
Methimazole Pharmacology Podcast
On this episode of the Real Life Pharmacology podcast, I cover methimazole adverse effects, mechanism of action, drug interactions, and much more!
Methimazole and propylthiouracil are from the same class of medications and are used for hyperthyroidism. I go over some of the differences between these agents in this podcast episode.
Methimazole is dosed once daily but can be split if the patient experiences significant GI adverse effects.
T3 plays an important role in hyperthyroidism. I discuss the physiologic of T3 production and how methimazole creates its effects to lower thyroid hormone levels.
Semaglutide (subQ) Pharmacology Podcast
On this podcast episode, I discuss the pharmacology, adverse effects, and drug interactions of semaglutide.
Semaglutide has two primary uses: Type 2 diabetes and Weight Management - the dosing varies depending upon the indication.
When using semaglutide, pay attention to GI adverse effects. Nausea, diarrhea, and vomiting are the most common ADRs and are dose-dependent.
Pay attention to corticosteroid bursts. They can cause substantial hyperglycemia and counteract the effects of diabetes medications like semaglutide.
Minocycline Pharmacology Podcast
Minocycline is a tetracycline antibiotic. I discuss pharmacology, adverse effects, and drug interactions.
Minocycline can cause sun sensitivity. Be sure to educate patients about this risk.
Metal cations like iron, zinc, calcium, and magnesium can bind minocycline and reduce the oral absorption of the medication.
Tooth discoloration is a possible adverse effect if minocycline is given to pediatric patients. I discuss it further in this episode.
Love the podcast but a note on recent research findings:
BPH is now shown to be PROTECTIVE against prostate cancer! PCa grows most often in the peripheral zone of the prostate and thus, reduction of the prostate (mainly the transitional zone) is postulated to increase risk of prostate cancer growth within the remaining tissue (peripheral zone).
Melissa-Urology NP in Texas!
Dr. Christianson is as quick and to the point as possible
Wonderful podcast when looking for study material or just a quick review. This podcast helps keep drugs fresh on my mind. Great for my commute as I study for my NAPLEX.
Excellent material! Thank you very much.