22 episodes

Topics looking at the technique for correcting defective genes responsible for disease development.

Regenerative Medicine and Gene Therapy International Centre for Genetic Engineering and Biotechnology

    • Science

Topics looking at the technique for correcting defective genes responsible for disease development.

    • video
    G. Sorrentino - New avenues in disease modeling and regenerative medicine of the enterohepatic system

    G. Sorrentino - New avenues in disease modeling and regenerative medicine of the enterohepatic system

    Giovanni Sorrentino, Head of Molecular Liver Pathophysiology Unit Department of Life Sciences – University of Trieste Trieste, ITALY speaks on "New avenues in disease modeling and regenerative medicine of the enterohepatic system".

    • 44 min
    • video
    S. Varghese - Physicochemical properties of extracellular matrix: Key to function, Clue to mechanism

    S. Varghese - Physicochemical properties of extracellular matrix: Key to function, Clue to mechanism

    Shyni Varghese, Professor & MEDx Investigator, Department of Biomedical Engineering, Mechanical Engineering and Materials Science Department of Orthopaedic Surgery, Pratt School of Engineering & Duke Medical Center, Durham, NC USA speaks on "Physicochemical properties of extracellular matrix: Key to function, Clue to mechanism". This movie has been recorded at ICGEB Trieste.

    • 42 min
    • video
    N. Ring - A screen is only the beginning

    N. Ring - A screen is only the beginning

    Nadja Ring completed her masters in Human biology at the Philipps University of Marburg, Germany, with a focus on molecular biology and genetics. Her passion for translational research and using science to improve health and wellbeing brought her to ICGEB, Trieste for her PhD in molecular biology. Here, Nadja Ring used high throughput screening to identify microRNAs able to combat cellular senescence, in the search of possible biotherapeutics to be used in aging related diseases. In her current position as a postdoctoral fellow in the group of Serena Zacchigna in ICGEB, Nadja Ring has continued to use high throughput screening to identify therapeutic solutions for a range of diseases, while also supervising PhD projects and being in charge of screening facility use for the group. Her main project is a transdisciplinary approach combining high throughput screening data with collaborations in machine learning and chemical compound synthesis. This has led to the identification of a novel compound which acts as a powerful anti-fibrotic drug in a mouse model of lung fibrosis. In addition to research, Nadja Ring also seeks to foster science diplomacy, by contributing to interregional projects, international workshops and outreach programs.

    • 33 min
    • video
    L. Hein - Dynamics of the epigenome in cardiac myocyte development and disease

    L. Hein - Dynamics of the epigenome in cardiac myocyte development and disease

    Lutz Hein, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany speaks on "Dynamics of the epigenome in cardiac myocyte development and disease". This movie has been recorded at ICGEB Trieste.

    • 49 min
    • video
    S. Lin - Designed linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy

    S. Lin - Designed linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy

    Shuo Lin, Biozentrum, University of Basel, Basel, SWITZERLAND speaks on "Designed linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy". This movie has been recorded at ICGEB Trieste.

    • 38 min
    • video
    J. Gil - Linking senescence and inflammation: the senescence-associated secretory phenotype (SASP)

    J. Gil - Linking senescence and inflammation: the senescence-associated secretory phenotype (SASP)

    Jesus Gil, Cell Proliferation Group MRC London Institute of Medical Sciences (LMS) Imperial College, Hammersmith Hospital Campus London, UK speaks on "Linking senescence and inflammation: the senescence-associated secretory phenotype (SASP)". This movie has been recorded at ICGEB Trieste.

    • 49 min

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