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Addressing antimalarial drug resistance in Africa to ensure patients can continue to be saved
We are pleased to be joined by Dorothy Achu, Regional Malaria Adviser, WHO African Region; Aimable Mbituyumuremyi, Director, National Malaria Control Program, Ministry of Health, Rwanda; Adam Aspinall, Senior Director, Access and Product Management, and George Jagoe, Executive Vice-President Medicines for Malaria Venture. To learn about antimalarial drug resistance in Africa to ensure patients can continue to be saved.
Could R399E Become a Promising Treatment for Restoring Joints and Relieving Pain in Osteoarthritis?
Osteoarthritis is a painful and progressive joint disorder that affects hundreds of millions of people worldwide. Typically, the options for treating the condition involve exercise or medication to reduce pain. However, these methods do not target the underlying structural problems in the joints of patients. Recently, researchers have uncovered a genetic susceptibility to osteoarthritis associated with a protein called GDF5, which is involved in skeletal growth and development. Alongside a team of scientists across Europe, Dr Kerstin Kleinschmidt-Doerr at Merck has explored a modified form of the GDF5 protein, named R399E, which showed effects in animal models and in-vitro experiments for treating pain and the underlying structural problems in osteoarthritis.
Understanding Diabetes: Revealing the Links Between High Blood Pressure and Insulin Resistance
Cases of type 2 diabetes are on the rise around the world, so gaining a deeper understanding of this chronic condition is vital to ensure early diagnosis and good outcomes for patients. Dr Xiaomu Li and her colleagues at Zhongshan Hospital, Fudan University are conducting important research to understand the risk factors associated with developing type 2 diabetes. Their findings will help healthcare providers to identify patients at high risk of diabetes, enabling early diagnosis and targeted interventions to prevent the development of the condition.
Prevent Children from Developing Dyslexia
Studies suggest that children who rely more on vision from their left eye could be more likely to develop dyslexia if they learn to write using pathways in the right brain hemisphere. Dr David Mather, a researcher at the University of Victoria, recently published a paper reviewing these findings. He outlines a proposed approach to teaching writing skills that could prevent these children from developing dyslexia. This approach involves teaching children to write when they are 7 or 8 years old, when the human brain is better at mapping and memorising entire words.
Decoding Dizziness in the Emergency Room
Acute vestibular syndrome is one of the most common reasons people present at hospital with dizziness. The symptoms can arise from damage within the brain or the ear, and specialist medical knowledge or equipment is typically needed to determine the specific cause. Dr Nakatsuka from the University of Sydney in Australia has conducted a large-scale analysis and review of the published literature to determine whether well-trained emergency physicians can differentiate between the two causes, using a quick bedside physical examination without expensive special equipment.
Multiverse of Madness: A Social-Ecological Tipping Point Analysis
Humans have driven dramatic environmental changes – most of which have a negative impact on us and other species. Today, we can only understand ecological systems by integrating the impacts of human activities, driven by our social systems. These social-ecological systems are dynamic, consisting of feedback loops and several interacting sub-systems – such as forests and agricultural production. The resilience of these systems is dependent on diversity – be it ecological or social. Beyond a certain point, a sub-system may cross a tipping point that changes the state of the whole system, potentially irreversibly, ushering in a new social-ecological state, which is typically less favourable than the former state. In recent research, an international team of experts has developed an advanced analytical framework to examine the tipping points within the social-ecological multiverse of the Southwestern Amazon.