24 episodes

Introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics.

Systems Biology (2014‪)‬ MIT

    • Science
    • 5.0 • 1 Rating

Introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics.

    • video
    Introduction to the class and overview of topics

    Introduction to the class and overview of topics

    In this lecture, Prof. Jeff Gore introduces the topics of the course, which broadly include gene networks and cellular decision-making, evolutionary systems biology, and ecological systems biology.

    • 1 hr 7 min
    • video
    Input function, Michaelis-Menten kinetics, and cooperativity

    Input function, Michaelis-Menten kinetics, and cooperativity

    Prof. Jeff Gore discusses the kinetics of gene expression. Simple input-output relationships and chemical/enzyme kinetics. Response time for stable proteins. Ultrasensitivity: cooperative binding or multimer molecular titration.

    • 1 hr 17 min
    • video
    Autoregulation, feedback and bistability

    Autoregulation, feedback and bistability

    Prof. Jeff Gore continues his discussion of gene expression, this time with a focus on autoregulation (when a gene regulates its own expression). He begins by discussing the network motif, then moves on to both negative and positive autoregulation.

    • 1 hr 18 min
    • video
    Synthetic biology and stability analysis in the toggle switch

    Synthetic biology and stability analysis in the toggle switch

    In this lecture, Prof. Jeff Gore discusses the toggle switch, or two genes that repress each other. He then moves on to dimensionless equations and stability analysis.

    • 1 hr 19 min
    • video
    Oscillatory genetic networks

    Oscillatory genetic networks

    Prof. Jeff Gore introduces oscillatory genetic networks. He asks why oscillations are useful, and why might we want to design an oscillator. Central to the lecture is a Nature article: A synthetic oscillatory network of transcriptional regulators.

    • 1 hr 21 min
    • video
    Graph properties of transcription networks

    Graph properties of transcription networks

    Prof. Jeff Gore continues the discussion of oscillators, including alternative designs for oscillators. He then discusses the article Emergence of scaling in random networks, by Barabási & Albert. The final topic is network motifs.

    • 1 hr 21 min

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