Tackling TMDD Models (Ep. 20‪)‬ Clinical Pharmacology Podcast with Nathan Teuscher

Today’s show is about TMDD or target-mediated drug disposition models. I review the scientific and physiologic basis for TMDD models, how to review data and determine if a TMDD model is needed. I review the various modeling approaches along with my recommendations for specific TMDD models. I hope this information helps you understand how to recognize TMDD behaviors and the options for modeling that data.

Links discussed in the show:


A tutorial on target-mediated drug disposition (TMDD) models
Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification
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