Talking About Tumors with Ryann and Ryan - A medical oncology podcast Talking About Tumors

 
Role for definitive chemotherapy and radiationControversy on induction chemotherapyConsiderations for nasopharyngeal cancerApproach to metastatic HNSCCCitations
As always, citations, and sources include education from our respective training programs, the Devita textbook, and Uptodate.com.  We highly encourage review of guidelines published by ASCO, ESMO and other organizations local to your practice.
DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015.
Uptodate.com Waltham, MA: Wolters Kluwer.
1.           Burtness B et al. J Clin Oncol. 2022;40(21):2321-2332. doi:10.1200/JCO.21.02198
2.           Burtness B et al. Lancet. 2019;394(10212):1915-1928. doi:10.1016/S0140-6736(19)32591-7
3.           Vermorken JB et al. NEJM 2008;359(11):1116-1127. doi:10.1056/NEJMOA0802656
4.           Gibson MK et al. JCO. 2005;23(15):3562-3567. doi:10.1200/JCO.2005.01.057
5.           Zhang L et al. Lancet. 2016;388(10054):1883-1892. doi:10.1016/S0140-6736(16)31388-5
6.           Zhang Y et al. NEJM. 2019;381(12):1124-1135. doi:10.1056/NEJMOA1905287
7.           Gau M et al. Oral Oncol. 2019;95:164-169. doi:10.1016/J.ORALONCOLOGY.2019.06.015
8.           GT W, et al. NEJM. 1991;324(24):1685-1690. doi:10.1056/NEJM199106133242402
9.           Lacas B et al. Radiother Oncol. 2021;156:281. doi:10.1016/J.RADONC.2021.01.013
10.        Bourhis  et al. JCO. 2004;22(14_suppl):5505-5505. doi:10.1200/JCO.2004.22.90140.5505
11.        Gyawali B et al. Cancer Treat Rev. 2016;44:10-16. doi:10.1016/J.CTRV.2016.01.002
12.        Forastiere AA et al. J Clin Oncol. 1992;10(8):1245-1251. doi:10.1200/JCO.1992.10.8.1245
13.        Posner MR et al. NEJM. 2007;357(17):1705-1715. doi:10.1056/NEJMOA070956/
 
Disclosures
Talking about Tumors with Ryan and Ryann is not medical advice.  We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose.  All opinions are those of whoever stated them.  We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic. 
Tags
Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, medical oncology
 

Anatomy, diagnostic work-up and stagingField cancerizationIndications for adjuvant concurrent chemoradiationEvidence to support weekly cisplatin with concurrent radiation

Citations
As always, citations, and sources include education from our respective training programs, the Devita textbook, and Uptodate.com.  We highly encourage review of guidelines published by ASCO, ESMO and other organizations local to your practice.
DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015.
Uptodate.com Waltham, MA: Wolters Kluwer.
1.           Bernier J et al. Head Neck. 2005;27(10):843-850. doi:10.1002/HED.20279
2.           Zevallos JP et al. Head Neck. 2021;43(1):108. doi:10.1002/HED.26465
3.           Young A, Okuyemi OT. StatPearls. Published online January 12, 2023. Accessed October 30, 2023. https://www.ncbi.nlm.nih.gov/books/NBK563022/
4.           Kiyota N et al.  J Clin Oncol. 2022;40(18):1980-1990. doi:10.1200/JCO.21.01293
5.           Sharma P et al. J Clin Oncol. 2022;40(16). doi: 10.1200/JCO.2022.40.16_suppl.6004
6.           Cooper JS et al. NEJM. 2004;350(19):1937-1944. doi:10.1056/NEJMOA032646
7.           Bernier J et al. NEJM. 2004;350(19):1945-1952. doi:10.1056/NEJMOA032641
 
Disclosures
Talking about Tumors with Ryan and Ryann is not medical advice.  We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose.  All opinions are those of whoever stated them.  We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic. 
Tags
Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, medical oncology
 

 
Presentation, and considerations for regional mesotheliomaSystemic therapy options for advanced mesotheliomaCorticosteroids for pemetrexed, paclitaxel and docetaxelA quick review on considerations for LCNEC Citations
As always, citations, and sources include education from our respective training programs, the Devita textbook, and Uptodate.com.  We highly encourage review of guidelines published by ASCO, ESMO and other organizations local to your practice.
DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015.
Uptodate.com Waltham, MA: Wolters Kluwer.


1.           Peters S et al. Ann Oncol. 2022;33(5):488-499. doi:10.1016/j.annonc.2022.01.074
2.           Baas P et al. Lancet. 2021;397(10272):375-386. doi:10.1016/S0140-6736(20)32714-8
3.           Vogelzang NJ et al. J Clin Oncol. 2003;21(14):2636-2644. doi:10.1200/JCO.2003.11.136
4.           Zalcman G, et al. Lancet. 2016;387(10026):1405-1414. doi:10.1016/S0140-6736(15)01238-6
5.           Santoro A, et al. J Thorac Oncol. 2008;3(7):756-763. doi:10.1097/JTO.0B013E31817C73D6
6.           Lindsay CR et al. Br J Cancer 2021;125(9):1210-1216. doi:10.1038/s41416-021-01407-9
 
Disclosures
Talking about Tumors with Ryan and Ryann is not medical advice.  We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose.  All opinions are those of whoever stated them.  We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic. 
Tags
Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, medical oncology
 

Background on SCLCApproach to treatment by stageEmerging discussion on prophylactic cranial irradiationBrief review of basket and umbrella trialsCitations
As always, citations, and sources include education from our respective training programs, the Devita textbook, and Uptodate.com.  We highly encourage review of guidelines published by ASCO, ESMO and other organizations local to your practice.
DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015.
Uptodate.com Waltham, MA: Wolters Kluwer.
1.           Trigo J et al. Lancet Oncol. 2020;21(5):645-654. doi:10.1016/S1470-2045(20)30068-1
2.           O’Brien MER et al. J Clin Oncol. 2006;24(34):5441-5447. doi:10.1200/JCO.2006.06.5821
3.           Rudin CM et al. J Clin Oncol. 2020;38(21):2369-2379. doi:10.1200/JCO.20.00793
4.           Paz-Ares L et al. The Lancet. 2019;394(10212):1929-1939. doi:10.1016/S0140-6736(19)32222-6
5.           Horn L et al NEJM. 2018;379(23):2220-2229. doi:10.1056/NEJMOA1809064/
6.           Lowenbraun S et al. Cancer. 1979;44:406-413. doi:10.1002/1097-0142
7.           Hochstenbag M et al.. J Neurooncol. 2000;48(3):243-248. doi:10.1023/A:1006427407281
8.           Meert AP et al. BMC Cancer. 2001;1(1):1-9. doi:10.1186/1471-2407-1-5/TABLES/4
9.           Fried DB et al.  J Clin Oncol. 2004;22(23):4785-4793. doi:10.1200/JCO.2004.01.178
10.        Pignon JP et al. 2010;327(23):1618-1624. doi:10.1056/NEJM199212033272302
11.        Warde P, Payne D.   J Clin Oncol. 1992;10(6):890-895. doi:10.1200/JCO.1992.10.6.890
12.        Wong AT et al. J Thorac Oncol. 2016;11(2):242-248. doi:10.1016/J.JTHO.2015.10.011
13.        Lu C  et al. Ther Innov Regul Sci. 2021;55(6):1145. doi:10.1007/S43441-021-00315-7
 
Disclosures
Talking about Tumors with Ryan and Ryann is not medical advice.  We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose.  All opinions are those of whoever stated them.  We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic. 
Tags
Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, medical oncology

Refresher on T+N staging for Stage IIIEvidence for concurrent chemoradiationPACIFIC TrialEncourage cessation regardless of stage of Lung Cancer 
Citations
As always, citations, and sources include education from our respective training programs, the Devita textbook, and Uptodate.com.  We highly encourage review of guidelines published by ASCO, ESMO and other organizations local to your practice.
DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015.
Uptodate.com Waltham, MA: Wolters Kluwer.


1.           Ajani JA et al.. Ann Oncol. 2013;24(11):2844-2849. doi:10.1093/ANNONC/MDT339
2.           Curran WJ et al. J Natl Cancer Inst. 2011;103(19):1452-1460. doi:10.1093/JNCI/DJR325
3.           Vokes EE, et al. JCO. 2007;25(13):1698-1704. doi:10.1200/JCO.2006.07.3569
4.           Dillman RO et al. NEJM. 1990;323(14):940-945. doi:10.1056/NEJM199010043231403
5.           Daly ME et al. JCO. 2022;40(12):1356-1384. doi:10.1200/JCO.21.02528
6.           Spigel DR et al. JCO. 2022;40(12):1301-1311. doi:10.1200/JCO.21.01308
7.           Antonia SJ et al. NEJM. 2017;377(20):1919-1929. doi:10.1056/NEJMOA1709937
8.           Senan et al. JCO. 2016;34(9):953-962. doi:10.1200/JCO.2015.64.8824
 
 
 
Disclosures
Talking about Tumors with Ryan and Ryann is not medical advice.  We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose.  All opinions are those of whoever stated them.  We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic. 
Tags
Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, medical oncology

Background on adjuvant EGFR therapy
Discussion of initial and updated results
Hazard Ratios and Context
When crossover and access limit generalizability


Citations
As always, citations, and sources include education from our respective training programs, the Devita textbook, and Uptodate.com.  We highly encourage review of guidelines published by ASCO, ESMO and other organizations local to your practice.
DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015.
Uptodate.com Waltham, MA: Wolters Kluwer.

1.Herbst et al. JCO.  2023;41(10):1830-1840. doi: 10.1200/JCO.22.02186
2.Wu et al. NEJM. 2023;383:1711-1723. doi:10.1056/NEJMoa2027071
3.       Tsuboi et al. NEJM. 2023;389(2):137-147. doi: 10.1056/NEJMoa2304594
4. West and Gyawali. JAMA Oncol. 2021;7(5):677-678. doi:10.1001/jamaoncol.2020.6752
5. Gyawali and West. JCO. 2021;39(3):175-177. doi: 10.1200/JCO.20.01762
6. Prasad. Plenary Session.  “ADAURA OS Results”. Podcast episode published June 8, 2023 
7. Haslan and Prasad. Ann Oncol. 2018; 29(5):1079–1081. doi: 10.1093/annonc/mdy116
8. Tannock et al. JCO.  2023;41(15):2713-2717 doi: 10.1200/JCO.23.00280


 
Disclosures
Talking about Tumors with Ryan and Ryann is not medical advice.  We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose.  All opinions are those of whoever stated them.  We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic. 

Tags
Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, medical oncology