The Carlat Psychiatry Podcast The Carlat Psychiatry Report

This study is the largest longitudinal study of cognition in lithium to date. Katherine Burdick and colleagues started with 262 patients with bipolar I – 64% were taking lithium [Link (https://www.nature.com/articles/s41386-020-0683-2?proof=t)]. They made two key measurements, with the main limitation that neither were controlled. Here's the findings.
Published On: 8/12/2020
Duration: 2 minutes, 49 seconds
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Silexan, an extract from Lavender with pharmaceutical properties, is one of only two treatments with a large effect size in generalized anxiety disorder. We rank all the treatments by strength and look to see if any of them can work when the SSRIs do not.
Published On: 8/10/2020
Duration: 26 minutes, 2 seconds
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We always say that single positive studies need replication, and here comes one. In 2012 a randomized trial found that the combination of topiramate and adderall xr worked better than placebo at helping people with frequent cocaine use stay sober. This new study [Link (https://pubmed.ncbi.nlm.nih.gov/31753736/)] sought to replicate that, although it was by the same research group as the original─Columbia’s New York State Psychiatric Institute. The new addition is a larger study looked at 127 patients over 3 months.
Published On: 8/8/20
Duration: 2 minutes, 16 seconds
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Dialectical Behavior Therapy ─ DBT ─ has become the gold standard for borderline personality disorder, and other therapies are starting to go head-to-head with DBT in clinical trials. We reviewed one that fared well, Good Psychiatric Management, in our Summer issue and a new one just came out of Australia in a study by Carla J Walton and colleagues from University of Newcastle [Link (https://journals.sagepub.com/doi/abs/10.1177/0004867420931164)]. It tested Conversational Therapy, which uses the careful listening and the therapeutic relationship as the fulcrum of change.
Date Published: 8/5/2020
Duration: 2 minutes, 24 seconds
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Are the SSRIs really that different? If a patient doesn't respond to one will they respond to another? We sift through three decades of research to find answers.
Published On: 8/3/20
Duration: 19 minutes, 13 seconds
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Electroconvulsive therapy (ECT) depends on the seizure threshold, so you don’t want to throw that off before starting it. Anticonvulsants and benzodiazepines are concerning, as are antidepressants. Although bupropion has a notorious risk for seizures, a recent meta-analysis of all antidepressants found buproprion’s risk was about average with the newer XL formulations and lower dose range, while the tricyclic clomipramine had the highest risk of seizures. [Link (https://pubmed.ncbi.nlm.nih.gov/31609275/)]
Published On: 8/1/2020
Duration: 1 minute, 58 seconds
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