29 episodes

Cellular function lies at the root of all complex and simple biological systems. This course will expose you to the fundamental mechanisms that allow cells to maintain the system of proteins and biomolecules required for them to replicate with high fidelity, to maintain stable functional states, to differentiate in response to external cues and to ultimately form complex organizations of cells (i.e., tissues). We will apply an experimental approach to a classic problem in cell biology. We will master “blackboard” experimental techniques to allow us to explore the remarkable transformation of a monolayer of cells after being “wounded.” Under such conditions, cells surrounding the wound change their organization and programming in order to migrate, divide, and differentiate to fill in the wound.

The Inner Workings of Cells, Winter 2008 UC Davis

    • Science
    • 5.0, 5 Ratings

Cellular function lies at the root of all complex and simple biological systems. This course will expose you to the fundamental mechanisms that allow cells to maintain the system of proteins and biomolecules required for them to replicate with high fidelity, to maintain stable functional states, to differentiate in response to external cues and to ultimately form complex organizations of cells (i.e., tissues). We will apply an experimental approach to a classic problem in cell biology. We will master “blackboard” experimental techniques to allow us to explore the remarkable transformation of a monolayer of cells after being “wounded.” Under such conditions, cells surrounding the wound change their organization and programming in order to migrate, divide, and differentiate to fill in the wound.

    Class Overview

    Class Overview

    Lecture 01: Kaplan discusses class mechanics, student questions and the central questions of cell biology.

    • 52 min
    Goals of Cell Biology

    Goals of Cell Biology

    Lecture 02: Goals of cell biologists and the overall course plan are discussed and students introduced to the question of how to study cells.

    • 52 min
    Antibodies

    Antibodies

    Lecture 03: This class reviews what characteristics a gene needs to be "necessary and sufficient." A discussion of antibodies and their application to various techniques of cell biologists.

    • 49 min
    Subcellular Fractionation

    Subcellular Fractionation

    Lecture 04: How to use subcellular fractionation and other techniques to study complex cellular processes and molecules.

    • 50 min
    Cell Membranes

    Cell Membranes

    Lecture 05: This class wraps up of tools to study complex cellular behavior (including microscopy), and introduces membrane proteins.

    • 53 min
    Membrane Reactions

    Membrane Reactions

    Lecture 06: This is a continued discussion of cellular membranes and their various functions in biochemical reactions.

    • 50 min

Customer Reviews

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5 Ratings

Purnie_Mae ,

Great!

I'm a med student in a pbl schooling environment. These lectures are a great resource to me that clarifies some of the sticky points in my reading. Am enjoying myself listening to these lectures. Thank you for them!

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