This Podcast Will Kill You Exactly Right

Fungal infections don’t often make an appearance on this podcast, but when they do, you know you’re in for a wild ride. In this episode, we explore the rare but potentially deadly fungal infection blastomycosis. We trace the journey of Blastomyces spores as they depart from their cozy homes of decomposing wood and make their way first into mammalian lungs before possibly moving into the skin, intestines, and brain. How and why these fungi can be so deadly is our next stop, one that takes us into an unexpected direction: the fall of dinosaurs, the rise of mammals and the role that pathogenic fungi played in this transition. We delve into why comparatively few fungi are pathogenic to humans and how our warm-bloodedness may protect us. But, as we discuss in the episode’s conclusion, that protection may be weakened as our warming planet selects for fungi that can tolerate increasing temperatures. Dinos, dogs, deep time, and deadly outbreaks - this episode has it all.

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There’s no denying that human imagination is a powerful thing. It has led us to create incredible works of art, literature that transports its readers to other realms, technology that revolutionizes the way we communicate and travel, music and film that makes us laugh, cry, and hit repeat. But our imagination often falls short when trying to conceive of the world from another person’s perspective, especially when it comes to senses. In this episode, we delve into one of the most prominent examples of this: color vision and color vision deficiencies. First, we take you through how color vision works and just how non-universal this experience is. We then explore the origins of color vision and what evolutionary significance it may have held before getting into the discovery of color vision deficiency and its impact on industry. We close out this colorful episode by chatting about some of the latest developments and products geared towards those with color vision deficiency.

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Hand, foot, and mouth disease (HFMD). The dreaded scourge of daycares, kindergartens, even occasionally college campuses, and the topic of this week’s episode. From the multiple viruses that cause HFMD to the wide array of symptoms (bye bye, fingernails), from the relatively recent discovery of this disease to the ancient origins of all viruses (deep time, y’all), from the changing nature of outbreaks to the development of potential vaccines (fingers crossed) - in this episode we’re going way beyond the basics of hand, foot, and mouth disease. Whether or not you’ve had the pleasure of being up close and personal with this disease, this episode is sure to leave you slightly horrified/mildly impressed by the infectiousness, longevity, resilience, and deep roots of the HFMD viruses.

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Most of us are familiar with asthma. Maybe you have the disease yourself or maybe a friend, family member, or coworker has it. Or maybe you’ve just watched a tv show or movie featuring a character with asthma. However you learned about this disease, you probably still have some lingering questions about it, like “how do inhalers work?”, “what are the different types of asthma?”, “where does the word asthma come from?”, “can other animals get asthma?”, and “can Erin and Erin tell me everything they possibly can about asthma?” The answer to that last question is a resounding yes, and the answers to the others you’ll find in today’s episode, where we take you through the complicated but somehow also straightforward biology of this disease, the long history of asthma peppered with firsthand accounts, and the promising research that may transform the way we live with this disease.

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Our final TPWKY book club selection of the season will test the limits of your imagination by asking you to consider what it might be like to smell the world through the nose of a dog or to see flowers through the ultraviolet vision of a bee. It will make you ponder the tradeoffs inherent in sensory perception and what an animal’s dominant senses can tell us about what is most important to their species. It will have you contemplating what the future holds for sensory research, both in terms of what new senses we might discover as well as the impacts of sensory pollution on an ecosystem. In short, it will change the way you perceive the world. Pulitzer Prize-winning science journalist Ed Yong joins us to chat about his incredible book, An Immense World: How Animal Senses Reveal the Hidden Realms Around Us. Yong, whose other book I Contain Multitudes is another TPWKY favorite, leads us on an expedition beyond the boundaries of human senses as we chat about what an octopus tastes, how the line between communication and perception is blurred in electric fish, the evolutionary arms race between bats and moths, and even the long-standing question of why zebras have stripes. Tune in for the riveting and magical conclusion to this season’s miniseries.

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The CDC’s list of highest priority bioterrorism agents is a short one, with only six pathogens making the cut. Among the more familiar names on the list, such as anthrax, botulism, plague, smallpox, and viral hemorrhagic fevers, is the topic of today’s episode: Francisella tularensis. Unless you’re a hunter or work with small mammals, you may not recognize the name of this pathogen or the disease it causes - tularemia - let alone the characteristics that earned it a place on the CDC’s list. By the end of this episode, though, all that will have changed. Join us as we explore why this pathogen’s brutal biology makes it a force to be reckoned with, how the history of its discovery has surprising origins in the devastating 1906 San Francisco earthquake, and what promises future research may hold for protection against this deadly disease.

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