This Week in Pediatric Oncology explores advances in childhood cancer with host Dr. Timothy Cripe from Nationwide Children\'s Hospital.
TWiPO #84: An Introduction to the ACCELERATE Platform with Dr. Gilles Vassal & Patricia Blanc
Hosts Dr. Tim Cripe and Dr. Brenda Weigel met with Dr. Gilles Vassal and Patricia Blanc on the ACCELERATE Platform: Innovation for Children and Adolescents with Cancer. Dr. Gilles Vassal is the head of Clinical Research at Institut Gustave Roussy in Villejuif, France & he is also the Chair for the ACCELERATE Steering Committee. Patricia Blanc is the President & Founder of the Imagine for Margo Foundation and serves as a Patient Advocate for ACCELERATE. Listen in to hear how the ACCELERATE platform came to be & the advances they are making within the childhood cancer research landscape. The ACCELERATE international platform provides a transparent forum to discuss and address, in a timely fashion, overarching issues in the development of innovative anticancer medicines for children and adolescents with cancer.
To learn more about ACCELERATE, please visit: https://www.accelerate-platform.org/
TWiPO #83 - Dr. Christopher Dandoy on transplant-associated thrombotic microangiopathy (TA-TMA)
Hosts Tim Cripe and Brenda Weigel welcome Dr. Chris Dandoy, from Cincinnati Children's Hospital, and parent advocate, Sarah Moore, to discuss the current research on TA-TMA and the implications for children undergoing stem cell transplant (SCT) for pediatric cancers, notably tandem SCTs for high-risk neuroblastoma.
Dr. Dandoy is Assistant Professor of Clinical Pediatrics in Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children’s Hospital Medical Center and this episode discussion focused on four recently published papers by Dr. Dandoy describing effects, incidence, risk factors, screening, and treatment of this serious complication of transplants. Sarah Moore also shared her perspective as a mother to a child who recently underwent tandem SCT for high-risk neuroblastoma, and has been active in parent forums discussing the incidence and implications of TA-TMA and sharing evidence-based information.
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TWiPO #82: Dr. Brenda Weigel on The RACE Act & Early Phase Clinical Trials
Host Tim Cripe welcomes his new Co-Host, Dr. Brenda Weigel, to reflect on her career, leadership, and focus areas since her last interview on TWiPO in 2017. Dr. Weigel is the Director of the Division of Pediatric Hematology/Oncology at the University of Minnesota's Cancer Center, Chair of Developmental Therapeutics in the COG, and Chair of the Pediatric Early Phase Clinical Trials Network (PEP-CTN) for the NCI.
She is at the epi-center for getting new drugs into the clinic for children with cancer and shares her perspective on the impact of the game-changing RACE Act that was implemented in 2020. She weighs in on prioritization of same-class drugs, evolving clinical trial design for small patient populations, and the increasing need for international collaboration in conducting clinical trials. She also discusses the importance of quality-of-life assessments and patient-reported outcomes and shares the efforts ongoing in the US and EU regulatory landscape to advance drug development for children with cancer.
Discussing Brain Tumor Research with Dr. Michael Taylor & Dr. Nabil Ahmed
This week was International Brain Tumor Awareness Week & we're closing out the week with this engaging discussion. TWIPO Host, Dr. Timothy Cripe, met with Dr. Michael Taylor, from SickKids in Toronto, Canada, and Dr. Nabil Ahmed, from Texas Children's Hospital, to discuss their recently published paper on a novel immunotherapy approach for children with metastatic medulloblastoma and ependymoma.
You can read their full paper here: https://pubmed.ncbi.nlm.nih.gov/32341580/
TWIPO: Interview with Douglas Hawkins, MD - Chair of Children's Oncology Group (COG)
This Week in Pediatric Oncology (TWIPO) - our host, Timothy Cripe, MD, meets with the new Chair of the Children's Oncology Group (COG), Douglas Hawkins, MD, to discuss the future of the pediatric cancer research landscape.
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The Pandemic's Impact on the Pediatric Cancer Research Landscape
• How is the pandemic changing current cancer care services?• What is the current state of open clinical trials and how will new, near-term trials be affected?• What is the impact on emerging new therapies and translational research?• Are there any silver linings to all of this for childhood cancer research?
These answers and more are discussed in this special episode for cancer families where leaders from COG, the NCI and the pharmaceutical industry lead a community discussion about the pandemic's impact on all aspects of pediatric cancer research including clinical trials and standard cancer care services, followed by Q&A with questions from families and attendees.
We are joined by:- Peter Adamson, MD – former Chair, Children's Oncology Group (COG) and current Global Head, Oncology Development & Pediatric Innovation, Sanofi
- Mark Kieran, MD, PhD – Pediatric Clinical Trial Lead, Bristol Myers Squibb
- Jeffery J. Auletta, MD - Director of the Blood and Marrow Transplant (BMT) Program and the Host Defense and Immunocompromised Infectious Diseases Program at Nationwide Children's Hospital.
- Carol Thiele, Ph.D, Deputy Chief, National Cancer Institute (NCI) Pediatric Oncology Branch
- Prof. Pamela Kearns President, European Society of Pediatric Oncology (SIOPE), Director of Cancer Research UK Clinical Trials Unit
Moderated by: Timothy P. Cripe, MD, PhD – Chief of Hematology and Oncology at Nationwide Children’s Hospital
Hosted by: Solving Kids' Cancer US & UK, and Max Cure Foundation
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Keep up the good work!
Just wanted to quickly thanks you guys for your continued effort to bring Peds Onc info to the masses. As a future fellow in the field, it’s been a blessing to have this resource and hear from so many accomplished docs about their journeys and current thoughts!