TWiV is a weekly netcast about viruses - the kind that make you sick. Professors Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler and science writer Alan Dove and guests deconstruct viruses, how they cause illness, and dissect the latest research.
Tuesday two: SARS-CoV-2 and TLR2
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.
The ferret nose where the virus goes
TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis.
COVID-19 clinical update #61 with Dr. Daniel Griffin
In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab.
Sputnik spat and furin in ferrets
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.
To err is viral
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats.
COVID-19 clinical update #60 with Dr. Daniel Griffin
In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae.
Superb except for Amy Rosenfeld
Every regular members are great to listen to except for Amy Rosenfeld. It’s not her voice but the way she speaks (semi-vocal fry) that gives my ears aural COVID-19.
Thank you for such an information packed podcast!
Absolutely love your all your podcasts! You all do such an excellent job of making science even more fascinating. Kudos & thanks for all the time devoted to every show!
Listen to this Podcast
TWIV is a reminder of all that is potentially great about the internet. Not only is Racaniello a world class virologist, he also happens to be a naturally great teacher (I am not his student). The rapport between the regular panelists is engaging and pleasant. The guests are at the cutting edge of the science. Intereated listeners should check out his virology course on You Tube. It's fantastic and free!