Translation is the process of turning basic scientific research into therapies that cure disease, new sources of energy that heal the planet, and other things that move the world forward.
The Translation podcast takes a deep dive into scientific advancements with a huge potential to improve society. We talk directly with the people advancing the science with their own hands and minds, and focus on how we can translate the science from the bench to the benefit of all.
Initially centered on biology and synthetic biology, we’ll talk with the most promising young scientists in the field. We aim to demystify the science for a general audience and to shine a light on how great science turns into great business. We hope these discussions will inspire scientists, entrepreneurs, and investors to help commercialize breakthrough research.
If you’re an author of an upcoming paper in bio or know of any interesting papers dropping soon and want to hear from the authors, drop us an email at email@example.com.
Designing A Better COVID19 Vaccine with Nikolai Eroshenko
Could all the leading COVID19 vaccines have a fatal flaw in their design? A dizzying number of vaccines are being developed to protect society from the dangers of COVID19, each with its own benefits and pitfalls. At HelixNano, Nikolai Eroshenko and his team are designing a special type of vaccine with increased attention to ensuring that this protective medicine doesn't accidentally improve the virus's ability to infect cells or drive the immune system to cause collateral damage. Nikolai describes how vaccines work, why so many are being developed to fight SARS-CoV-2, and how technological advances have allowed us to develop them faster than ever before. Most importantly, Nikolai calls on all vaccine developers to put more effort into their design and testing pipeline such that they don’t accidentally help the virus become more deadly.
Evolving AAVs for Gene Therapy with Pierce Ogden
Powered by synthetic biology, Pierce Ogden makes ALL possible mutations to an adeno-associated virus (AAV) outer shell and rapidly screens them to dissect their attributes. Pierce discusses the technological advances that make this breakthrough screen possible and the novel properties that were discovered. AAVs are rapidly becoming the prefered way to perform gene therapy, correcting cells that carry disease-causing mutations through genetic modification. This technology forms the basis for company Dyno Therapeutics.
Evolving Enzymes to Create Unnatural Compounds with Tina Boville
Commodity molecules are vital ingredients for everything important to our modern world including food, energy, and medicine. However, creating these molecules still largely relies on old processes that suffer from low yield, laborious methods, and unsustainable inputs and byproducts. Tina envisions a world where all molecules are created quickly, easily, and sustainably through enzymes, biology’s chemical catalyst. Here, Tina describes how she used an extremely powerful method called directed evolution to build a novel enzyme that can create the non-canonical amino acid 4-cyanotryptophan, a fluorescent molecule that is extremely difficult to make with traditional chemistry.
Low-N Protein Engineering with Surge Biswas
Protein engineering has been dominated by two opposing paradigms; directed evolution, a massive screening technique, and rational design, a completely computational approach. Surge has fused these two paradigms by developing a machine learning technique that discovers an optimal protein design by training on a low number of engineered proteins. Here, Surge discusses how this hybrid method works, how it enabled the creation of better fluorophores and enzymes, and what this method will unlock next.
Customer ReviewsSee All
Excellent scientific discussions.
This podcast combines a detailed and rigorous look at the science behind each topic with hopeful, futuristic discussion about its potential. Loved every episode so far.
Great podcast on new biology papers
Super enjoyable! Will be subscribing!
overview of new publications
podcast provided a great overview of a new publication on protein engineering. super cool to hear from the actual graduate student!