Deep Dive On

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Deep Dive On is a podcast exploring research, science, and health through peer-reviewed academic papers. Each episode breaks down complex studies into engaging discussions, highlighting discoveries that shape science, medicine, and wellbeing. Whether you're a researcher, student, or curious mind, Deep Dive On offers clear insights and thoughtful analysis of the research that impacts our understanding of the world.

  1. قبل ٦ أيام

    Iron-Dependent Telomerase Reactivation Drives Colorectal Cancer

    This research article investigates the mechanistic link between high iron levels and the development of colorectal cancers (CRCs), focusing on the reactivation of telomerase, an enzyme associated with cellular immortalization. The authors identify Pirin, an iron-sensing protein, as a crucial mediator that binds with oxidized iron (Fe3+) to reactivate the human telomerase reverse transcriptase (hTERT) subunit. This finding provides a molecular explanation for the known association between high dietary iron intake (such as red meat consumption) and increased CRC risk. Furthermore, the study pinpoints a small molecule, SP2509, which inhibits this process by competing with Fe3+ for binding to Pirin, suggesting a novel therapeutic approach for targeting telomerase-driven cancers, particularly those of the CMS3 subtype. The mechanism involves iron-activated Pirin stabilising the transcription factor Sp1 by repressing the E3 ubiquitin ligase FBXW7, which consequently drives hTERT expression. Research paper: Shanmugam R, Majee P, Shi W, Ozturk MB, Vaiyapuri TS, Idzham K, Raju A, Shin SH, Fidan K, Low JL, Chua JYH, Kong YC, Qi OY, Tan E, Chok AY, Seow-En I, Wee I, Macalinao DC, Chong DQ, Chang HY, Lee F, Leow WQ, Murata-Hori M, Xiaoqian Z, Shumei C, Tan CSH, Dasgupta R, Tan IB, Tergaonkar V. Iron (Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers. Cancer Discov. 2024 Oct 4;14(10):1940 1963. Click here to read the article Voiced by NotebookLM   Disclaimer

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  2. ١٣ أكتوبر

    How Parenting Rewires the Brain for Lifelong Mental Health

    This academic paper explores the impact of parenting styles, specifically harsh and warm approaches, on adolescent brain architecture and subsequent mental health outcomes in early adulthood. It investigates whether these associations are dependent on the child's developmental stage, early, middle, or late childhood, rather than simply accumulating over time. The study found that psychological aggression in early childhood was linked to widespread changes in brain organisation, while later aggression affected specific emotional regulation circuits. Conversely, warm parenting during middle childhood was associated with positive changes in corticolimbic regions, which, in turn, predicted lower anxiety and depression in young adults, even during the stress of the COVID-19 pandemic. These findings highlight the importance of timing and type of parental intervention for supporting neurodevelopment and long-term well-being. Research paper: Michael C, Gard AM, Tillem S, Hardi FA, Dunn EC, Smith ADAC, McLoyd VC, Brooks-Gunn J, Mitchell C, Monk CS, Hyde LW. Developmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health. JAMA Pediatrics. 2024 Dec 1;178(12):1326-1336. Click here to read the article Voiced by NotebookLM Disclaimer

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  3. ٢٩ سبتمبر

    Epigenetic Clocks Measuring Your Biological Age and Unlocking the Future of Healthspan

    This article provides an overview of DNA methylation aging clocks, which are molecular tools used to measure an individual's age based on specific chemical modifications to their DNA. The authors discuss the current understanding and significant challenges in utilising these clocks, particularly in distinguishing between chronological age and biological aging. They also explore the utility of tissue- and disease-specific clocks and the importance of integrating epigenetics into large-scale longitudinal population studies to better understand aging dynamics. This paper then addresses the need for broader genome-wide analyses and the exploration of other epigenomic marks, as well as the potential and challenges of single-cell analysis to uncover cellular heterogeneity in aging. Finally, the authors emphasise the necessity of robust non-human data for mechanistic insights and the critical ethical and legal frameworks required for responsible application of these technologies. Review paper: Bell, C.G., Lowe, R., Adams, P.D. et al. DNA methylationaging clocks: challenges and recommendations. Genome Biol 20, 249 (2019) Click here to read the article Voiced by NotebookLM Disclaimer

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  4. ١٥ سبتمبر

    Early-life sugar rationing protects against diabetes and hypertension

    This research article investigates the long-term effects of early-life sugar intake on the development of type 2 diabetes and hypertension. Utilising a natural experiment from the end of sugar rationing in the UK in 1953, the study compares adults with varying levels of sugar exposure during their first 1000 days. The findings suggest that restricted sugar intake in early life significantly reduced the risk and delayed the onset of both conditions. This highlights the critical impact of early nutrition on lifelong metabolic health, with in-utero sugar restriction also showing a protective effect. Review paper: Gracner T, Boone C, Gertler PJ. Exposure to sugar rationing in the first 1000 days of life protected against chronic disease. Science. 2024 Nov 29;386(6725):1043-1048. Click here to read the article Voiced by NotebookLM Disclaimer

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  5. ١ سبتمبر

    Vaccine reactogenicity

    This review article thoroughly examines vaccine reactogenicity, which encompasses the common, often mild, inflammatory responses individuals experience post vaccination, such as soreness or fever. The authors explore the underlying biological mechanisms that cause these reactions, detailing how the body's immune system responds to vaccine components. Furthermore, the paper investigates various factors that can influence reactogenicity, including host characteristics, vaccine composition, and administration techniques. Ultimately, the article aims to enhance understanding among healthcare professionals and the public to maintain confidence in vaccination programmes by managing expectations and mitigating anxiety related to side effects. Review paper: Hervé, C., Laupèze, B., Del Giudice, G. et al. The how’s and what’s of vaccine reactogenicity. npj Vaccines 4, 39 (2019). Click here to read the article Voiced by NotebookLM Disclaimer

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  6. ١٨ أغسطس

    KIBRA anchors PKMζ for memory persistence

    This research article investigates how long-term memories persist despite the turnover of brain molecules. The study reveals that a protein called KIBRA physically interacts with the enzyme PKMζ at synapses activated during learning. This KIBRA-PKMζ complex acts as a stable anchor, maintaining the synaptic changes underlying memory storage. Blocking this interaction with specific inhibitors disrupts established long-term potentiation and erases both recent and remote memories in animal models, highlighting the crucial role of this continuous molecular coupling in memory maintenance. Review paper: Tsokas P, Hsieh C, Flores-Obando RE, Bernabo M, Tcherepanov A, Hernández AI, Thomas C, Bergold PJ, Cottrell JE, Kremerskothen J, Shouval HZ, Nader K, Fenton AA, Sacktor TC. KIBRA anchoring the action of PKMζ maintains the persistence of memory. Sci Adv. 2024 Jun 28;10(26):eadl0030. Click here to read the article Voiced by NotebookLM Disclaimer

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  7. ١٨ أغسطس

    Dietary inflammation and mortality risk in coronary heart disease

    This research investigated the connection between the Dietary Inflammatory Index (DII) and the risk of all-cause mortality in adults with coronary heart disease (CHD) using data from a national health survey. The study found that higher DII scores, indicating a more pro-inflammatory diet, were associated with a greater risk of death in these patients. Notably, this association appeared stronger in women with CHD. The findings suggest that managing dietary inflammation could be an important factor in improving outcomes for individuals with CHD, particularly for females. However, due to the study's design, further research is needed to confirm a direct cause-and-effect relationship. Research paper: Wang, E., Fang, C., Zhang, J. et al. Association between dietary inflammatory index and all-cause mortality risk in adults with coronary heart disease in the United States. Sci Rep 14, 23998 (2024).   Click here to read the article Voiced by NotebookLM Disclaimer

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  8. ٤ أغسطس

    SARS-CoV-2 vaccine response

    This research investigated the durability of SARS-CoV-2 specific plasma cells generated after mRNA vaccination by examining bone marrow samples. The study found that, unlike influenza and tetanus, SARS-CoV-2-specific antibody secreting cells were largely absent from the long-lived plasma cell compartment in the bone marrow up to 33 months post-vaccination. Consequently, the waning of SARS-CoV-2 serum antibodies observed after vaccination could be attributed to this lack of establishment in the long lived compartment. The findings suggest that mRNA vaccines for SARS-CoV-2 do not induce the same durable plasma cell response in bone marrow as traditional vaccines, offering a potential explanation for the relatively short-livedprotection against infection. This highlights the need for strategies to improve the longevity of antibody responses elicited by SARS-CoV-2 vaccines. Research paper: Nguyen, D.C., Hentenaar, I.T., Morrison-Porter, A. et al. SARS CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination. Nat Med 31, 235–244 (2025). Click here to read the article Voiced by NotebookLM Disclaimer

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Deep Dive On is a podcast exploring research, science, and health through peer-reviewed academic papers. Each episode breaks down complex studies into engaging discussions, highlighting discoveries that shape science, medicine, and wellbeing. Whether you're a researcher, student, or curious mind, Deep Dive On offers clear insights and thoughtful analysis of the research that impacts our understanding of the world.

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