The Optispan Podcast with Matt Kaeberlein Optispan

Subscribe to our channel: https://www.youtube.com/@optispan

Check out the Sutphin Lab: https://sutphinlab.org/

Related episodes:

Uncovering New Longevity Research DISCOVERIES: The Power of 3HAA Revealed: https://youtu.be/CFVQUSVJmIk
People are GETTING THIS WRONG about Supplements & My Supplement List: https://youtu.be/_UXk_ynCNUs
DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw
Does this Dog Supplement Really Work to REVERSE AGE? (PART 1): https://youtu.be/-ujIfZXGbDA

George Sutphin is back! So many of you enjoyed Matt's interview with him back in March 2024 about 3HAA and NAD+ that we decided to bring him on the podcast once again to chat about the potential effects of oral NMN supplementation.

You may have heard of over-the-counter supplements aimed at boosting nicotinamide adenine dinucleotide (NAD+) levels. Underlying these supplements is the hypothesis that levels of NAD+, a central coenzyme found in all living cells and involved in innumerable biochemical reactions that include DNA repair, glycolysis, stress responses, and more, decrease with age. The decrease may be associated with aging and age-related disease, and restoring NAD+ levels via supplementation is therefore likely to increase health- and/or lifespan.

In this episode, Matt and George examine a recent finding that oral supplementation of NAD+ boosters increases molecular signatures that indicate kidney damage. They discuss the NAD+ signaling pathway, models for how NAD+ might drive kidney damage, how they would expand upon the study for further research, and more.

University of Arizona Assistant Professor of Molecular and Cellular Biology George Sutphin runs a lab that investigates genetic determinants of longevity, the effects of kynurenine-based interventions on lifespan, and environmental regulators of the aging process. George, who was an aerospace engineer before he discovered the promise of geroscience, completed his PhD at the University of Washington and worked as a postdoctoral associate at the Jackson Laboratory prior to his current faculty position. He currently serves as Chairperson of the American Aging Association.


Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

More places to find us:

Twitter: https://twitter.com/optispanpodcast
Twitter: https://twitter.com/optispan
Twitter: https://twitter.com/mkaeberlein
Linkedin: https://www.linkedin.com/company/optispan

https://www.optispan.life/

Help keep the Dog Aging Project alive (prizes available!): https://donor-list.org/go/QGkYGQcLFL
More about the Dog Aging Project: https://dogagingproject.org/
Enroll your dog in the Dog Aging Project: https://redcap.dogagingproject.org/su...
The Dog Aging Institute: dogaginginstitute.org

Save the Dog Aging Project!

In 2014, Matt co-founded the Dog Aging Project, an ambitious, large-scale study of canine health and longevity aimed at understanding how dogs—and, eventually, humans—age. The project has two broad goals: to help us understand the biology of aging, and to enable us to do something about it. A third goal that often goes unmentioned, but is (to some) no less important, is to give us more time with furry friends who often become part of the family.

Dogs are some of the best animals we can use to study longevity. While many of the model organisms such as yeast, worms, mice, and rats that we commonly use to study aging have certainly helped us unearth interesting insights, they typically live in highly controlled laboratory conditions that do not replicate the diverse environmental factors that humans experience. Researchers also often use inbred strains of these animals due to their genetic uniformity, a practice that offers experimental advantages but also introduces issues such as limited generalizability and undetected gene-environment interactions. Meanwhile, dogs share our environments in every way, develop the same age-related diseases as do humans, exhibit high genetic diversity, and age rapidly enough that we do not have to wait decades to observe the effects of interventions on dog life- and healthspan.

The Dog Aging Project has grown to become the world's largest study of aging. Over 50,000 dogs are currently enrolled in the project, enabling researchers to create an immense dataset comprising over 36 million data points and a biobank containing more than 10,000 samples that will be invaluable to helping us answer key questions about the biology of aging. Data from the project has contributed to the publication of over 50 peer-reviewed scientific papers. As this is a citizen science project that harnesses the collective power of volunteers to contribute to scientific research, the Dog Aging Project will make all data publicly available free of charge to academics and nonprofit institutions to facilitate the blooming of as much useful research as possible.

The Dog Aging Project needs your help. Federal funding to the project has recently been withdrawn, and the project needs financial backing to support its veterinary and computational infrastructure as well as to complete a clinical trial of rapamycin in dogs. The project hopes to decrease its reliance on federal funding and thus hopes to encourage philanthropic funding as far possible. Top donors stand to receive a full Optispan Trailblazer concierge clinic experience and lunch with Matt, and other donors may receive Optispan swag.

Every contribution, no matter the size, makes a difference. We hope you will consider donating!

Subscribe to our channel: https://www.youtube.com/@optispan

Is bigger always better?

It depends. Throughout the human lifespan, body size plays an important role in determining health outcomes and quality of life. It's not just about body mass index, fat distribution, weight, or muscle mass: there also exists a relationship between body size and longevity across multiple species, including humans. On average, larger species seem to live longer and age more slowly—think about the fact that dogs age about seven times faster than do humans, who are both heavier and taller than dogs. But within species, that relationship flips around: larger individuals age more rapidly and live shorter lifespans than do smaller individuals.

As with seemingly everything in aging, the relationship between body size and the rate of aging is complex and the result of an interplay between genetic, environmental, and lifestyle factors, most of which scientists are still investigating. In this episode of Longevity Science, Matt dives into the nuances of body size and aging rate, discussing currently available data about how the two interact, intriguing outliers and exceptions, and potential molecular and evolutionary drivers.


Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

More places to find us:

Twitter: https://twitter.com/optispanpodcast
Twitter: https://twitter.com/optispan
Twitter: https://twitter.com/mkaeberlein
Linkedin: https://www.linkedin.com/company/optispan

https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!