Jeffrey Mogil: Pain, Placebo Effects, Medicine, Neuroscience | R-Academy Episode 2 R-Academy
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- Education
In this episode, I had the pleasure of speaking with Dr. Jeffrey Mogil. He is the E.P. Taylor Professor of Pain Studies at McGill University and the Canada Research Chair in Genetics of Pain (Tier 1). His lab (MOGILab) studies the multi-varied subject of Pain in both humans and mice. He is known for his work in Pain Genetics, pain measurements, furthering the research on sex differences in pain perception and processing, investigating the pharmacology of various analgesics (pain drugs), and as well as studying the neurochemistry of the placebo and nocebo effects. His understanding of the topics of pain are vast, and his expertise is extremely valuable – I am immensely grateful to have hosted him for my second episode.
In this episode, we discuss a wide array of topics; most of which are centered around the nuances of Pain. These nuances include the discussion of How to Define Pain, what are current pain treatments and how effective (or ineffective) they are, what is the placebo effect and how can it be used ethically (or unethically), what are the common pain sex differences, the opioid crisis and its relation to pain, and we conclude our episode with a discussion about the nature of science and research.
I hope you enjoy this episode, all topics are time-stamped below.
1:29 - 5:29 (Background)
5:30 - 9:22 (Pain Genetics)
9:23 - 11:01 (How do environments influence genetic expression)
11:02 - 14:55 (What is pain?)
14:56 - 16:11 (Underfunding of pain)
16:12 - 17:48 (Morbidity vs mortality)
17:49 - 19:44 (How to buffer against chronic pain)
19:45 - 20:03 (What are analgesics?)
20:04 - 21:18 (What are the psychological treatments for pain?)
21:19 - 22:44 (Are the treatments equally effective)
22:45 - 23:29 (Therapeutic Alliance for treatment gains)
23:30 - 26:15 (Best analgesics for pain?)
26:16 - 28:12 (What do opioids do for pain?)
28:13 - 29:31 (Why Tylenol is mysterious)
29:32 - 31:11 (New Evidence in Psychedelics Functionality) [1]
31:12 - 32:49 (Non-Traditional pain medicines)
32:50 - 34:19 (What is a placebo effect)
34:20 - 36:19 (Neurochemistry of the placebo effect)
36:20 - 41:05 (Is administering a placebo ethical?)
41:06 - 44:43 (Medical Doctors Dispensing Placebo Effects)
44:44 - 46:18 (How effective is placebo compared to drugs?)
46:19 - 47:27 (What is the opposite of the placebo effect?) [2]
47:28 - 48:55 (What is the neurochemistry of the Nocebo Effect?)
48:56 - 50:35 (How to ascribe functionality to neurochemicals)
50:36 - 52:26 (Are hormones involved in pain?)
52:27 - 55:05 (The role of testosterone in pain)
55:06 - 1:01:53 (What are the sex differences in pain?)
1:01:54 - 1:04:11 (Why is the opioid crisis occurring in men?)
1:04:12 - 1:07:21 (How to improve prescription policies of opiates)
1:07:22 - 1:11:07 (The meaning of Academia after a successful career)
1:11:08 - 1:14:28 (Lumping vs Splitting) [3]
1:14:29 - 1:15:41 (If Money was no object, what would you study?)
1:15:42 - End (What topics are hard to get funding for?)
In this episode, I had the pleasure of speaking with Dr. Jeffrey Mogil. He is the E.P. Taylor Professor of Pain Studies at McGill University and the Canada Research Chair in Genetics of Pain (Tier 1). His lab (MOGILab) studies the multi-varied subject of Pain in both humans and mice. He is known for his work in Pain Genetics, pain measurements, furthering the research on sex differences in pain perception and processing, investigating the pharmacology of various analgesics (pain drugs), and as well as studying the neurochemistry of the placebo and nocebo effects. His understanding of the topics of pain are vast, and his expertise is extremely valuable – I am immensely grateful to have hosted him for my second episode.
In this episode, we discuss a wide array of topics; most of which are centered around the nuances of Pain. These nuances include the discussion of How to Define Pain, what are current pain treatments and how effective (or ineffective) they are, what is the placebo effect and how can it be used ethically (or unethically), what are the common pain sex differences, the opioid crisis and its relation to pain, and we conclude our episode with a discussion about the nature of science and research.
I hope you enjoy this episode, all topics are time-stamped below.
1:29 - 5:29 (Background)
5:30 - 9:22 (Pain Genetics)
9:23 - 11:01 (How do environments influence genetic expression)
11:02 - 14:55 (What is pain?)
14:56 - 16:11 (Underfunding of pain)
16:12 - 17:48 (Morbidity vs mortality)
17:49 - 19:44 (How to buffer against chronic pain)
19:45 - 20:03 (What are analgesics?)
20:04 - 21:18 (What are the psychological treatments for pain?)
21:19 - 22:44 (Are the treatments equally effective)
22:45 - 23:29 (Therapeutic Alliance for treatment gains)
23:30 - 26:15 (Best analgesics for pain?)
26:16 - 28:12 (What do opioids do for pain?)
28:13 - 29:31 (Why Tylenol is mysterious)
29:32 - 31:11 (New Evidence in Psychedelics Functionality) [1]
31:12 - 32:49 (Non-Traditional pain medicines)
32:50 - 34:19 (What is a placebo effect)
34:20 - 36:19 (Neurochemistry of the placebo effect)
36:20 - 41:05 (Is administering a placebo ethical?)
41:06 - 44:43 (Medical Doctors Dispensing Placebo Effects)
44:44 - 46:18 (How effective is placebo compared to drugs?)
46:19 - 47:27 (What is the opposite of the placebo effect?) [2]
47:28 - 48:55 (What is the neurochemistry of the Nocebo Effect?)
48:56 - 50:35 (How to ascribe functionality to neurochemicals)
50:36 - 52:26 (Are hormones involved in pain?)
52:27 - 55:05 (The role of testosterone in pain)
55:06 - 1:01:53 (What are the sex differences in pain?)
1:01:54 - 1:04:11 (Why is the opioid crisis occurring in men?)
1:04:12 - 1:07:21 (How to improve prescription policies of opiates)
1:07:22 - 1:11:07 (The meaning of Academia after a successful career)
1:11:08 - 1:14:28 (Lumping vs Splitting) [3]
1:14:29 - 1:15:41 (If Money was no object, what would you study?)
1:15:42 - End (What topics are hard to get funding for?)