Probably Science Andy Wood, Matt Kirshen

Comedian Shane Mauss (@shane_mauss) returns to the podcast in the midst of his A Better Trip tour to talk with Matt and Andy about having his van broken into, his new line of plant activated products, the connection between Amanita muscaria mushrooms and Mario and Santa, the trendiness of ketamine, a psychedelic toad venom that may have therapeutic uses (and that, of course, Shane has already tried), a wounded orangutan using a plant as medicine, and discount presale passes for To 29 and Beyond that are available until the May 10th announcement of some big lineup additions!

Comedian Sierra Katow (@sierrakatow) joins Jesse, Andy and Matt to talk about her new standup special Funt, the upcoming appearance on Roots of Comedy with Jesus Trejo, the underrated Earth to Ned, Sierra's computer science background and childhood obsession with Neopets, Andy's head-scratching interaction with Anthropic's Claude AI, deadly pathogens that are attracted to human blood, the importance of robot insurance, the security issues raised by quantum computing, online Oregon Trail, a black hole lurking surprisingly close to Earth and To 29 and Beyond, coming to Outpost 29 on June 7-8, with Bobcat Goldthwait, NASA's Farah Alibay, stargazing, trivia, live music, karaoke and more, sponsored by Visit 29, Merch Kitchen and Sky Watcher Star Tours. For 15% off a Sky Watcher stargazing tour, use the code "29BEYOND".

Comedian Bec Hill (@bechillcomedian) joins Andy, Matt and Jesse to talk about What3Words, Bec sneaking dicks into things, a surprise from decades-old cans of salmon, ghost particles, a possible Stonehenge moon connection, ancient Stonehenge feasts, Willy's LA Chocolate Experience, A Problem Squared, Enemy In Paris and of course To 29 and Beyond, coming to Outpost 29 on June 7-8, with Bobcat Goldthwait, NASA's Farah Alibay, stargazing, trivia, live music, karaoke and more, sponsored by Visit 29, Merch Kitchen and Sky Watcher Star Tours. For 15% off a Sky Watcher stargazing tour, use the code "29BEYOND".

Comedian Joshua Snyder (@nerdyvirgin) joins Matt, Jesse and Andy to talk about Bobcat Goldthwait headlining To 29 and Beyond, Jesse's love life, building a guitar, a lack of solar eclipse whimsy, the Star Trek punk on a bus, toxic epi-pens in space, a mouse with legs instead of genitals, dog comprehension, the great podcast Free With Ads and a SPATS update.

Comedian Carmen Morales (@TheFunnyCarmen) joins Andy, Jesse and Matt to talk about Matt's chipped tooth, the pros and cons of home dentistry, a nuclear fusion record, CRISPR and HIV, Andy's friend's Pioneertown-to-Big Bear breakdown, a million mice eating seabirds alive, letdowns from CBD, Carmen on HBO, updates from the Large Hadron Collider and our live event To 29 and Beyond, taking place June 7th and 8th.

Comedian/juggler Marcus Monroe (@marcusmonroe) joins Jesse, Matt and Andy to talk about inventing the knorch, siteswap juggling notation, getting banned from Delta Airlines, a Montana man pleading guilty to creating massive franken-sheep, getting helium from the moon and To 29 and Beyond, now taking place June 7th and 8th.