Exploration Science with Dr. Wendy Hartsock and Dr. Diedra Shorty Dr. Wendy Hartsock and Dr. Diedra Shorty

In this episode of Exploration Science, CEO and Co-founder of Numaferm, Dr. Christian Schwarz, and peptide manufacturing expert, Dr. Alain Scarso, discuss the peptide therapeutics market and dive into the technology of Numaswitch – a transformative biochemical platform to produce peptides, pepteins, and proteins.

In this episode of Exploration Science, Pepticom co-founders, Dr. Immanuel Lerner and Dr. Amit Michaeli, discuss the advantage of employing biocomputational AI software to optimize peptide drug discovery, reduce development risks, and accelerate time to market.

In this episode of Exploration Science, Dr. James Nowick (University of California, Irvine) and Dr. Nick Truex (University of South Carolina) delve into the complexities of designing, synthesizing, and examining biologically significant peptides. They also share fond memories of their time working together in the lab.

In this episode of ExplorationScience, Dr. Jonathan Steckbeck, the founder and CEO of Peptilogics, discusses the company's approach to peptide drug discovery. Tune into this episode to learn how partnering biology with machine learning is guiding the intelligent navigation of peptide chemical space to develop next-generation therapeutics.

In this episode of Exploration Science, Dr. David Shoultz,
Chief Operating Officer & Co-Founder of Monod Bio discusses the next
generation of clinical diagnostics and how the company is transforming point of
care for patients. Tune in and learn how scientists at Monod Bio are driving
diagnostic innovation through de novo protein design and
deploying lucCage technology. This platform is based on research conducted
by Dr. David Baker and scientists at the University of Washington Institute for
Protein Design to generate artificial luciferases with optimized size,
stability, substrate specificity, and photophysical properties.

In this episode of Exploration Science, Drs. Ronald Frank (AIMS Scientific Products GmbH) and
Christian Behn (CEM) discuss the evolution of SPOT Synthesis to generate
peptide libraries. They also correct some misinformation and bring to light the
ease and utility of applying SPOT arrays to biological studies.  



Watch on YouTube: https://youtu.be/MBJFIygXDRg



Correction: The founding of AIMS company was in 1998, not 1989.

 

See the links and references below for some examples of SPOT applications:

AIMS Scientific Products http://www.aims-scientific-products.de/index.php

CEM MultiPep: https://cem.com/multipep2

Clemens Schulte, Vladimir Khayenko, Amit Jean Gupta, Hans Michael Maric. Low-cost
synthesis of peptide libraries and their use for binding studies via
temperature-related intensity change. STAR Protocols. Volume 2, Issue 3,
2021, 100605. https://doi.org/10.1016/j.xpro.2021.100605.

 Melder FTI, Lindemann P, Welle A, Trouillet V, Heißler S, Nazaré M, Selbach M. Compound
Interaction Screen on a Photoactivatable Cellulose Membrane (CISCM) Identifies
Drug Targets. ChemMedChem. 2022 Oct 6;17(19):e202200346. doi:
10.1002/cmdc.202200346. Epub 2022 Sep 20. PMID: 35867055; PMCID: PMC9826412.

 Mohammed El-Mowafy, Ursula Bilitewski. Identification of possible Ser/Thr/Tyr
phosphorylation sites in the fungal histidine kinase CaNik1p by peptide array
technique. Bulletin of Faculty of Pharmacy, Cairo University. Volume 56,
Issue 1, 2018, Pages 68-72. https://doi.org/10.1016/j.bfopcu.2018.03.007.

 Moreno-Yruela, C., Bæk, M., Vrsanova, AE. et al. Hydroxamic acid-modified peptide
microarrays for profiling isozyme-selective interactions and inhibition of
histone deacetylases. Nat Commun 12, 62 (2021). https://doi.org/10.1038/s41467-020-20250-9.

 Meyer et al., Mutations in Disordered Regions Can Cause Disease by Creating Dileucine
Motifs. Cell (2018), https://doi.org/10.1016/j.cell.2018.08.019.

Rebollo, A., Fliedel, L., Tuffery, P., PEPscan: A Broad-Spectrum Approach for the
Characterization of Protein-Binder Interactions? Biomolecules 2022, 12,
178. https://doi.org/10.3390/

Rosie M. Jarrald, Aw W. Liang Alvin, Andrea E. Rawlings, Masayoshi Tanaka, Mina Okochi,
and Sarah S. Staniland. Systematic Screening and Deep Analysis of CoPt
Binding Peptides Leads to Enhanced CoPt Nanoparticles Using Designed Peptides. Bioconjugate
Chemistry 2020 31 (8), 1981-1994. DOI: 10.1021/acs.bioconjchem.0c00348.