4-Quarter Lives

Avivah Wittenberg-Cox
4-Quarter Lives

You are likely to live longer than you think. Are you ready? Science has gifted us ever longer, 100-year lives. This impacts… everything! From couples and careers - to companies and countries. We’ll interview the experts who are exploring the consequences – and the individuals applying it to their own lives and choices. Generational and gender expert Avivah Wittenberg-Cox talks with people designing new ways of living, working and loving at all ages – across life’s 4 quarters. elderberries.substack.com

  1. 6 DAYS AGO

    Saher Mehdi: Ageing & Gender at a Cellular Level

    In this week’s 4-Quarter Lives, Avivah Wittenberg-Cox is joined by Dr. Saher Mehdi- molecular biologist, longevity researcher, and healthcare entrepreneur, to explore what it truly means to age well. Saher traces her journey “from molecules to meaning,” beginning with a childhood curiosity sparked by her grandmother’s ageing hands. That moment led to a lifelong inquiry into the biology of ageing, one that took her across continents and disciplines. With a PhD from Durham University and postdoctoral research at Oxford, Uppsala, and KU Leuven, her research has spanned cell fate, cardiac regeneration, epigenetics, and the stress responses that shape how, and how fast, we age. But her understanding of ageing evolved beyond the lab. Living and working in the UK, Sweden, and Belgium deepened her appreciation for how biology is shaped by culture, climate, and inequality. Returning to India, she saw the urgent need to translate cutting-edge science into accessible, personalised tools, especially in a country where 1 in 6 people will be over 60 by 2050, and where rising rates of diabetes and heart disease reveal a unique intersection of genetic vulnerability and environmental risk. Through her company ReWise Health, Saher is building a new approach to ageing — using AI and biomarker data to assess biological age, personalise interventions, and prevent disease before it strikes. She makes the case that ageing itself, not just chronic diseases, is the leading driver of mortality, and that slowing cellular ageing could add more healthy years to life than curing cancer or heart disease. In a striking metaphor, she compares female mitochondria to fuel-efficient hybrid engines, while male mitochondria resemble high-performance machines that burn through energy faster, illustrating the cellular gender gap in ageing. Saher continues to unpack the science of gendered ageing through telomeres, the protective caps at the ends of chromosomes that erode with time and stress. Women, she notes, tend to have longer telomeres and slower attrition, thanks to estrogen and the second X chromosome. But she also critiques the deep male bias in medical research: for decades, women, particularly post-50, have been excluded from clinical trials, creating massive knowledge gaps in care. She calls for a shift in longevity science, away from elite biohacking and toward public health equity, especially for ageing women in low-resource settings. Through ReWise, she’s designing a culturally relevant, scalable model for biological age testing and intervention, one rooted in empathy, science, and real-world impact. Dr. Saher Mehdi is a molecular biologist, epigenetics expert, and two-time founder in the field of preventive health and longevity. She founded Wellowise and now leads ReWise Health, a cutting-edge biotech building tools to personalise ageing and extend healthspan. With a PhD from Durham and postdoctoral research at Oxford, Uppsala, and Leuven, her work spans cell fate, cardiac regeneration, cellular stress, and the biology of ageing. A global voice in the science of longevity, Dr. Mehdi is redefining how we understand, measure, and optimise the experience of growing older with data, compassion, and vision. Useful Links: * ReWise Health website * Saher Mehdi’s Substack blog * Saher’s X account * Saher Linkedin Get full access to Elderberries at elderberries.substack.com/subscribe

    38 min
  2. 25 JUN

    Richard Leider: The Power & Potential of Purpose

    This week, on 4-Quarter Lives, Avivah Wittenberg-Cox talks with Richard Leider, founder of Inventure – The Purpose Company, and one of America’s pre-eminent executive-life coaches. Ranked by Forbes as one of the “Top 5” most respected executive coaches, and by the Conference Board as a “legend in coaching”, he and Avivah explore a life devoted to helping others uncover meaning across the lifespan. Richard traces his journey back to his early days as a listener, when questions of “why” ignited his lifelong focus on purpose. A pivotal encounter with Viktor Frankl shaped his core philosophy: purpose is not something to seek, but something to contribute. Influences from both Frankl and Maslow emphasised that true fulfilment comes from serving others—whether in big or small ways. Richard distinguishes between “Big P” and “little p” purpose, suggesting that even everyday contributions can profoundly shape one’s life. He speaks candidly about how purpose supports health, longevity, and emotional well-being, now backed by science, including the telomere effect. Cross-cultural wisdom—from African hunter-gatherers to boardrooms—affirms a universal desire for relevance and connection. Richard also addresses gendered paths to purpose, noting that women more readily explore meaning in later life, while many men confront unfulfillment after success. At 80, he continues writing and speaking in flow, advocating for relevance over retirement. His message is clear: purpose is not a luxury—it’s essential. Richard Leider is an internationally recognised coach, author and speaker. He has written twelve books, including three best sellers, which have sold over one million copies and been translated into 20 languages. The Power of Purpose is considered a classic in the personal growth field. His PBS Special – The Power of Purpose – was viewed by millions across the U.S. Richard is the founder of Inventure – The Purpose Company, a firm created to guide individuals to live, work, and lead on purpose. He has worked with leaders from organizations such as AARP, Ameriprise, Blue Zones, Blue Spirit, Ericsson, General Mills, Habitat for Humanity, Lifespark, Mayo Clinic, Modern Elder Academy, National Football League, Outward Bound, Optum, Pfizer, United Health Group, and the U.S. Dept of State. Richard holds a master’s degree in Counseling and has been recognized with many awards including a Bush Fellowship, and the Outstanding Scholar for Creative Longevity and Wisdom award from the Fielding Institute. He is a Senior Fellow at the University of Minnesota’s Earl E. Bakken Center for Spirituality and Healing, and an Education Fellow with the Retirement Income Institute. He also serves as a Purpose Ambassador for Blue Zones and Blue Spirit Costa Rica. For over 30 years, he has led Inventure Expedition walking safaris in East Africa where he is a founder and a board member of the Dorobo Fund for Tanzania. Useful Links: * Richard’s website * Richard’s blog * Book: Who Do You Want to Be When You Grow Old?: The Path of Purposeful Aging by Richard Leider and David Shapiro (2021) * Amazon.com * Amazon UK * Book: The Power of Purpose, by Richard Leider and David Shapiro (4th Edition, 2025) * Amazon.com * Amazon UK Get full access to Elderberries at elderberries.substack.com/subscribe

    39 min
  3. 11 JUN

    Neeraj Sagar: Wisdom At (Late) Work

    On 4-Quarter Lives this week Avivah Wittenberg-Cox talks with Neeraj Sagar, founder and CEO of WisdomCircle.com, a platform connecting experienced professionals in Q3 with purposeful, flexible work across the globe. Targeting individuals typically over 50—termed the “Wisdom Generation” or “WisGen”—the platform facilitates engagements across sectors like IT, manufacturing, education, and social impact, allowing retirees to contribute as mentors, consultants, or part-time experts.  WisdomCircle leverages AI-driven matching to align retirees’ expertise with organizational needs, ensuring roles are compensated to recognise their value. WisdomCircle emphasizes respect and purpose, avoiding unpaid roles and promoting initiatives like the “One Million Teachers” program to integrate seasoned professionals into educational and advisory positions. With a growing presence in the UK, Europe, the Middle East, Africa and Singapore, WisdomCircle aspires to become the world’s leading marketplace for senior talent, fostering multigenerational collaboration and challenging traditional notions of retirement. Neeraj Sagar, founder and CEO of WisdomCircle, brings a rich tapestry of experience from global consulting and leadership roles. He served as a senior partner at Egon Zehnder, leading its Industrial Practice across Asia-Pacific, the Middle East, and Africa. Earlier he worked at McKinsey & Company in Singapore, the Boston Consulting Group in Chicago, and engineering roles at Schlumberger and Engineers India Limited. Neeraj holds an MBA from the University of Chicago Booth School of Business, an MS in Petroleum Engineering from Stanford University, and a bachelor’s degree in Chemical Engineering from TKIET in India. Useful Links: * WisdomCircle website Get full access to Elderberries at elderberries.substack.com/subscribe

    44 min
  4. 4 JUN

    Farah Baxter & Ignacio Moreno: Legacy is More Than Money, It’s Also Memories

    This week on 4-Quarter-Lives, Avivah Wittenberg-Cox talks with Ignacio Moreno and Farah Baxter, the Co-Founders of a pioneering digital platform that reimagines legacy planning by enabling individuals to create and share personalized emotional and practical legacies. Soalma was born from their personal experiences with loss and the realization of the importance of preserving memories and wisdom for future generations.  The platform offers a secure, user-friendly space where users can compile multimedia content— videos, audio messages, photos, and documents—to capture life stories, advice, and heartfelt messages. These digital legacies can be shared with loved ones either during the user’s lifetime or posthumously, ensuring that personal histories and values endure. Soalma’s mission is to make legacy planning accessible and emotionally resonant. By providing intuitive templates and prompts, the platform helps users in articulating their narratives. This approach not only aids in preserving individual and family histories but also supports emotional well-being by fostering reflection and connection. Since its inception, Soalma has garnered recognition for its innovative approach. The startup was a finalist in the Expansión Startup Awards 2023, secured third place in the GBO Startup Awards, and received accolades from French Tech and SilverEco & Aging Well Awards. Looking ahead, Soalma aims to expand its reach through B2B partnerships, particularly with organizations focused on elder care and long-term planning. The team is also exploring the integration of artificial intelligence to further personalize the legacy creation process. With its headquarters in Madrid, Soalma continues to grow its user base, striving to make legacy planning a meaningful and accessible experience for all.  Ignacio Moreno and Farah Baxter both have MBAs from INSEAD Business School. They met at an alumni event and discovered they had both recently lost close loved ones. Individually, they had started working on developing solutions to better address what they had found lacking in the grieving process. They decided to join forces and so founded Soalma. Ignacio Moreno is an entrepreneur and experienced corporate manager and consultant. Prior to Soalma he was CFO of Grupo IGNIS, an energy company in Spain. He also conceived and founded the MasterChef online school, which has since spread from Spain internationally. He has a BA in Law and Economics from Universidad Pontificia Comillas. Farah Baxter has extensive experience in Strategy Management at Hint Inc, Heineken, Booz & Co and Tata Realty. She has a BSc in Business Administration from Boston University. Useful Links: SOALMA Website: www.soalma.com. Get full access to Elderberries at elderberries.substack.com/subscribe

    41 min
  5. 28 MAY

    Laurie Kilby and Katie Waldegrave: Now Foster – And Enrich Your Life

    On this week’s 4-Quarter Lives Avivah Wittenberg-Cox talks with Laurie Kilby and Katie Waldegrave, co-founders of Now Foster, a bold new initiative reimagining how we recruit and support foster carers. Laurie, a former social worker, and Katie, co-founder of Now Teach, have teamed up to tackle one of the most urgent and overlooked social issues of our time: the crisis in foster care. Building on the success of Now Teach, which helped hundreds transition into teaching in their 50s, Now Foster invites the same generation to consider a different kind of legacy: becoming part-time foster carers—Weekenders. They explain how fostering can become a civic, shared responsibility, and why this phase of life—often rich in time, energy, and desire for meaning—is ideally suited for people to contribute. Katie and Laurie share the origin story of Nw Foster, the systemic challenges, and the everyday joys of becoming a consistent, caring presence in a child’s life. It’s a stirring, smart reinvention of foster care—one weekend a month. One child. One adult or one couple. One small idea that could change lives. Laurie Kirby is Co-Founder and Practice Lead for Now Foster. A former secondary school teacher and social worker, she is herself a Now Foster carer for a young boy and works with local authorities to match children already in foster care to weekend carers. Katie Waldegrave MBE is a serial founder and lead of non-profits including, most recently, Now Foster. Previously she was co-founder, with Lucy Kellaway, of Now Teach, set up in 2016 to encourage people in mid-career to shift to teaching, and before that was co-founder and first Chief Executive of First Story, which placed writers in residence into secondary schools to help young people to nurture their creativity. Earlier, from 2003-8 she was a teacher and one of the first cohort of First Teach, an initiative to encourage new graduates to enter teaching. Useful Links: * Interested in becoming a Weekender? Want to explore how fostering fits into your Q3? Visit nowfoster.org to learn more or attend one of their info sessions. Everyone welcome—no couple, home ownership or previous experience required. * Weekenders: BBC Story of Sara and her young person * Now Teach – Midlife career changes into teaching Get full access to Elderberries at elderberries.substack.com/subscribe

    30 min
  6. 21 MAY

    Lisa Goldsobel: Living Inter-generationally, By Design

    In this episode of 4-Quarter Lives, Avivah Wittenberg-Cox talks with Lisa Goldsobel, Head of Service Delivery for Two Generations, a UK-based social enterprise tackling two growing challenges: the loneliness of the older and the unaffordable housing for the younger. Founded in 2019, Two Generations scales the concept of Homesharing, where carefully matched housemates live together—typically an older homeowner and a younger sharer who provides companionship and light support in exchange for affordable accommodation. Companionship Not Caregiving Lisa Goldsobel explains the thoughtful vetting, matching and support process that underpins successful and safe co-living arrangements. Homeshare is not a caregiving model but a mutually beneficial companionship arrangement, often lasting well over a year. Financially, it’s an affordable solution for both parties and includes bursary support. The conversation also explores a new frontier: offering HomeShare as a corporate benefit. With eldercare demands surpassing childcare, Two Generations helps employers support staff struggling to balance work and caregiving responsibilities. The goal is to retain valuable talent—particularly women—while improving wellbeing and productivity. From heartwarming stories to policy-shifting insights, this episode highlights how HomeShare is transforming lives and could reshape how society supports ageing populations and the modern workforce. Lisa Goldsobel is responsible for ensuring the successful delivery of the nationwide operations of the Homeshare Scheme. She manages the vetting process, ensures safeguarding compliance, and provides ongoing support for householders and for sharers. She leads the operational strategy to scale the Homesharing scheme effectively, while maintaining standards of care, safety and efficiency. Useful Links: * Two Generations Website * Homeshare as Employee Benefit – The Corporate Benefits Get full access to Elderberries at elderberries.substack.com/subscribe

    30 min
5
out of 5
3 Ratings

About

You are likely to live longer than you think. Are you ready? Science has gifted us ever longer, 100-year lives. This impacts… everything! From couples and careers - to companies and countries. We’ll interview the experts who are exploring the consequences – and the individuals applying it to their own lives and choices. Generational and gender expert Avivah Wittenberg-Cox talks with people designing new ways of living, working and loving at all ages – across life’s 4 quarters. elderberries.substack.com

You Might Also Like

To listen to explicit episodes, sign in.

Stay up to date with this show

Sign in or sign up to follow shows, save episodes and get the latest updates.

Select a country or region

Africa, Middle East, and India

Asia Pacific

Europe

Latin America and the Caribbean

The United States and Canada