Episode 12: A SPRINT Through HTN Trials The Nephron Segment: A Kidney Podcast
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- Medicine
In Episode 12, Dr. William Cushman, co-investigator of the 2015 SPRINT (Systolic Blood Pressure Intervention) Trial, joins us for a discussion all about hypertension trials, their long history, and what's ahead for research in this space. Too young to remember SPRINT or looking for a "CliffsNotes (https://en.wikipedia.org/wiki/CliffsNotes)" of HTN trials? This episode's for you!Here's a Renal Fellow Network post from 2017 (https://www.renalfellow.org/2017/02/25/awesome-htn-trial-cheat-sheet-and-info/) with a link to a cheat sheet of hypertension clinical trial.Nephrons: Matthew Sparks (http://twitter.com/nephro_sparks), Samira Farouk (http://twitter.com/ssfarouk)Guests: William Cushman (https://www.uthsc.edu/faculty/profile/?netid=wcushman), Medical Director & Professor, Department of Preventive Medicine, University of TennesseeLinks from the Show:00:41: Systolic Blood Pressure Intervention Trial (https://www.nejm.org/doi/full/10.1056/nejmoa1511939) (2015)02:17: VA Cooperative Study (https://jamanetwork.com/journals/jama/article-abstract/336799) (1967)05:13: ACCORD Study (https://www.nejm.org/doi/full/10.1056/nejmoa1001286) (2010)06:30: SPRINT MIND (https://jamanetwork.com/journals/jama/fullarticle/2723256) (2019)08:40: Framingham Heart Study (https://www.framinghamheartstudy.org) (Started 1948)11:27: Attended vs. unattended blood pressure – learnings beyond SPRINT (https://www.tandfonline.com/doi/full/10.1080/08037051.2021.1995981) (https://www.tandfonline.com/doi/full/10.1080/08037051.2021.1995981)(2021)14:03: Systolic Hypertension in the Elderly Program Study (https://pubmed.ncbi.nlm.nih.gov/2676266/) (1989)14:05: Hypertension Detection & Follow Up Program (https://pubmed.ncbi.nlm.nih.gov/490882/) (1979)15:32: JNC 8 Guidelines (https://jamanetwork.com/journals/jama/fullarticle/1791497) (2014)16:01 AHA/ACC Guidelines (https://www.jacc.org/doi/10.1016/j.jacc.2017.11.006?_ga=2.34767585.1501841999.1703862545-2086556452.1703862545) (2017)17:54: Syst-Eur (https://www.ajconline.org/article/S0002-9149(98)00752-8/fulltext) (Treatment of HTN in Patients > 60 y, 1998)17:54: HYVET (https://www.nejm.org/doi/full/10.1056/nejmoa0801369)(Treatment of HTN in Patients > 80 y, 2008)18:01: Syst-China (https://pubmed.ncbi.nlm.nih.gov/10647760/) (2000)22:18: AAFP HTN Guidelines (https://www.aafp.org/pubs/afp/issues/2022/1200/practice-guidelines-aafp-hypertension-full-guideline.html#:~:text=The%20AAFP%20strongly%20recommends%20clinicians,%3B%20high-quality%20evidence).) (2022)22:40: KDIGO HTN Guidelines (https://kdigo.org/guidelines/blood-pressure-in-ckd/) (2021)25:37: ALLHAT Study (https://jamanetwork.com/journals/jama/fullarticle/195626) (2002)32:22: Secondary Prevention of Small Subcortical Strokes Trial (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60852-1/fulltext) (SPS3, 2013)
In Episode 12, Dr. William Cushman, co-investigator of the 2015 SPRINT (Systolic Blood Pressure Intervention) Trial, joins us for a discussion all about hypertension trials, their long history, and what's ahead for research in this space. Too young to remember SPRINT or looking for a "CliffsNotes (https://en.wikipedia.org/wiki/CliffsNotes)" of HTN trials? This episode's for you!Here's a Renal Fellow Network post from 2017 (https://www.renalfellow.org/2017/02/25/awesome-htn-trial-cheat-sheet-and-info/) with a link to a cheat sheet of hypertension clinical trial.Nephrons: Matthew Sparks (http://twitter.com/nephro_sparks), Samira Farouk (http://twitter.com/ssfarouk)Guests: William Cushman (https://www.uthsc.edu/faculty/profile/?netid=wcushman), Medical Director & Professor, Department of Preventive Medicine, University of TennesseeLinks from the Show:00:41: Systolic Blood Pressure Intervention Trial (https://www.nejm.org/doi/full/10.1056/nejmoa1511939) (2015)02:17: VA Cooperative Study (https://jamanetwork.com/journals/jama/article-abstract/336799) (1967)05:13: ACCORD Study (https://www.nejm.org/doi/full/10.1056/nejmoa1001286) (2010)06:30: SPRINT MIND (https://jamanetwork.com/journals/jama/fullarticle/2723256) (2019)08:40: Framingham Heart Study (https://www.framinghamheartstudy.org) (Started 1948)11:27: Attended vs. unattended blood pressure – learnings beyond SPRINT (https://www.tandfonline.com/doi/full/10.1080/08037051.2021.1995981) (https://www.tandfonline.com/doi/full/10.1080/08037051.2021.1995981)(2021)14:03: Systolic Hypertension in the Elderly Program Study (https://pubmed.ncbi.nlm.nih.gov/2676266/) (1989)14:05: Hypertension Detection & Follow Up Program (https://pubmed.ncbi.nlm.nih.gov/490882/) (1979)15:32: JNC 8 Guidelines (https://jamanetwork.com/journals/jama/fullarticle/1791497) (2014)16:01 AHA/ACC Guidelines (https://www.jacc.org/doi/10.1016/j.jacc.2017.11.006?_ga=2.34767585.1501841999.1703862545-2086556452.1703862545) (2017)17:54: Syst-Eur (https://www.ajconline.org/article/S0002-9149(98)00752-8/fulltext) (Treatment of HTN in Patients > 60 y, 1998)17:54: HYVET (https://www.nejm.org/doi/full/10.1056/nejmoa0801369)(Treatment of HTN in Patients > 80 y, 2008)18:01: Syst-China (https://pubmed.ncbi.nlm.nih.gov/10647760/) (2000)22:18: AAFP HTN Guidelines (https://www.aafp.org/pubs/afp/issues/2022/1200/practice-guidelines-aafp-hypertension-full-guideline.html#:~:text=The%20AAFP%20strongly%20recommends%20clinicians,%3B%20high-quality%20evidence).) (2022)22:40: KDIGO HTN Guidelines (https://kdigo.org/guidelines/blood-pressure-in-ckd/) (2021)25:37: ALLHAT Study (https://jamanetwork.com/journals/jama/fullarticle/195626) (2002)32:22: Secondary Prevention of Small Subcortical Strokes Trial (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60852-1/fulltext) (SPS3, 2013)