The Nephron Segment: A Kidney Podcast Samira Farouk, Sam Kant, Elinor Mannon, Matthew Sparks

It’s Episode 13 of The Nephron Segment and it's time for NephMadness (https://ajkdblog.org/2024/03/01/welcome-to-nephmadness-2024/)! Join us as we chat with transplant nephrologist Dr. Roslyn Mannon & transplant hepatologist Dr. Elizabeth Aby and discuss all things dual-organ transplantation: liver-kidney, pancreas-kidney, kidney after liver, kidney after pancreas, or even kidney alone?! Listen to the end to hear everyone's picks for NephMadness 2024 (https://ajkdblog.org/2024/03/01/nephmadness-2024-dual-organ-transplant-region/).And to be clear, Dr. Mannon supported the Kansas City Chiefs before their Super Bowl 58 win.Submit your NephMadness brackets here (nephmadness.com) (just like March Madness!) by 3/31. Maximize your changes by submitting 2 brackets per email address.Nephrons: Matthew Sparks (http://twitter.com/nephro_sparks), Samira Farouk (http://twitter.com/ssfarouk)Guests: Roslyn Mannon (twitter.com/mannonmom), Lizzie Aby (twitter.com/lizzieabyMD)

In Episode 12, Dr. William Cushman, co-investigator of the 2015 SPRINT (Systolic Blood Pressure Intervention) Trial, joins us for a discussion all about hypertension trials, their long history, and what's ahead for research in this space. Too young to remember SPRINT or looking for a "CliffsNotes (https://en.wikipedia.org/wiki/CliffsNotes)" of HTN trials? This episode's for you!Here's a Renal Fellow Network post from 2017 (https://www.renalfellow.org/2017/02/25/awesome-htn-trial-cheat-sheet-and-info/) with a link to a cheat sheet of hypertension clinical trial.Nephrons: Matthew Sparks (http://twitter.com/nephro_sparks), Samira Farouk (http://twitter.com/ssfarouk)Guests: William Cushman (https://www.uthsc.edu/faculty/profile/?netid=wcushman), Medical Director & Professor, Department of Preventive Medicine, University of TennesseeLinks from the Show:00:41: Systolic Blood Pressure Intervention Trial (https://www.nejm.org/doi/full/10.1056/nejmoa1511939) (2015)02:17: VA Cooperative Study (https://jamanetwork.com/journals/jama/article-abstract/336799) (1967)05:13: ACCORD Study (https://www.nejm.org/doi/full/10.1056/nejmoa1001286) (2010)06:30: SPRINT MIND (https://jamanetwork.com/journals/jama/fullarticle/2723256) (2019)08:40: Framingham Heart Study (https://www.framinghamheartstudy.org) (Started 1948)11:27: Attended vs. unattended blood pressure – learnings beyond SPRINT (https://www.tandfonline.com/doi/full/10.1080/08037051.2021.1995981) (https://www.tandfonline.com/doi/full/10.1080/08037051.2021.1995981)(2021)14:03: Systolic Hypertension in the Elderly Program Study (https://pubmed.ncbi.nlm.nih.gov/2676266/) (1989)14:05: Hypertension Detection & Follow Up Program (https://pubmed.ncbi.nlm.nih.gov/490882/) (1979)15:32: JNC 8 Guidelines (https://jamanetwork.com/journals/jama/fullarticle/1791497) (2014)16:01 AHA/ACC Guidelines (https://www.jacc.org/doi/10.1016/j.jacc.2017.11.006?_ga=2.34767585.1501841999.1703862545-2086556452.1703862545) (2017)17:54: Syst-Eur (https://www.ajconline.org/article/S0002-9149(98)00752-8/fulltext) (Treatment of HTN in Patients > 60 y, 1998)17:54: HYVET (https://www.nejm.org/doi/full/10.1056/nejmoa0801369)(Treatment of HTN in Patients > 80 y, 2008)18:01: Syst-China (https://pubmed.ncbi.nlm.nih.gov/10647760/) (2000)22:18: AAFP HTN Guidelines (https://www.aafp.org/pubs/afp/issues/2022/1200/practice-guidelines-aafp-hypertension-full-guideline.html#:~:text=The%20AAFP%20strongly%20recommends%20clinicians,%3B%20high-quality%20evidence).) (2022)22:40: KDIGO HTN Guidelines (https://kdigo.org/guidelines/blood-pressure-in-ckd/) (2021)25:37: ALLHAT Study (https://jamanetwork.com/journals/jama/fullarticle/195626) (2002)32:22: Secondary Prevention of Small Subcortical Strokes Trial (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60852-1/fulltext) (SPS3, 2013)

In Episode 11, guests Jordy Cohen & Samir Parikh (and members of the American Society of Nephrology Kidney Week Education Committee (https://www.asn-online.org/about/committees/committee.aspx?panel=KWEC)) join us for a discussion about Kidney Week 2023 (https://www.asn-online.org/education/kidneyweek/2023/meeting-overview.aspx#:~:text=Annual%20Meeting%20in%20Philadelphia%2C%20PA,or%20hybrid%20event%20in%202023.) and their careers as physician-scientists. They discuss their journeys to their current careers, what inspired them to pursue nephrology ("beautiful ribbons of anti-GBM"), and share their advice for trainees. For more on Kidney Week 2023, here's (https://www.doximity.com/articles/2f805b32-e972-40e0-81f3-4d00f3308f05) a Doximity op-ed.Nephrons: Matthew Sparks (http://twitter.com/nephro_sparks), Samira Farouk (http://twitter.com/ssfarouk)Guests: Jordy Cohen (twitter.com/jordy_bc), Samir Parikh (twitter.com/samirparikhmd)Links from the Show:02:03: PLA2R & Membranous Nephropathy (2009) (https://www.nejm.org/doi/full/10.1056/NEJMoa0810457)04:03: Sflt-1 (https://www.nejm.org/doi/full/10.1056/nejmoa1414838#:~:text=A%20high%20ratio%20of%20sFlt,risk%20than%20either%20biomarker%20alone.&text=Proteinuria%20and%20elevated%20blood%20pressure,the%20clinical%20presentation%20is%20variable.)05:05: FLOW & GLP-1 (https://pubmed.ncbi.nlm.nih.gov/36651820/)05:55: ACC HTN Guidelines (2017) (https://www.ahajournals.org/doi/10.1161/HYP.0000000000000065)09:33: Bill McKibben Plenary: Too Hot & Inhuman Temperatures (https://www.asn-online.org/education/kidneyweek/2023/program-search.aspx?q=7656835&type=faculty)10:45: Climate change & heat stress nephropathy (https://journals.lww.com/cjasn/Fulltext/2016/08000/Climate_Change_and_the_Emergent_Epidemic_of_CKD.22.aspx#:~:text=Mechanism%20for%20heat%20stress%20nephropathy,hyperthermia%2C%20and%20extracellular%20volume%20depletion.)11:00: Ardem Patapoutian Plenary: How Do You Feel? The Molecules that Sense Touch (https://www.asn-online.org/education/kidneyweek/2023/program-session-details.aspx?sessId=464176)13:03: Obesity & RAS Activation (Mice) (https://www.ahajournals.org/doi/10.1161/01.HYP.35.1.329)

Episode 10: Green Nephrology (April 20, 2023) (https://blubrry.com/nephron_segment/95805726/episode-10-green-nephrology/)On Episode 10, we celebrate Earth Day with guests Dr. Katherine Barraclough & Dr. Megha Salani who share with us the startling amount of waste that both hemodialysis and peritoneal dialysis generate, what climate change means for kidney disease, and what we can do to protect our planet and "go green." They also share how they became interested in the burgeoning field of green nephrology, in addition to the considerable carbon footprint associated with KRT. We delved into the pathogenesis of heat induced kidney injury and how climate change is now considered a public health emergency. Nephrons: Elinor Mannon (http://twitter.com/elinormannon), Sam Kant (http://twitter.com/kantsmd), Matthew Sparks (http://twitter.com/nephro_sparks), Samira Farouk  (http://twitter.com/ssfarouk)Guests: Katherine Barraclough, Megha Salani (https://publish.blubrry.com/s-1464288/episodes/new/twitter.com/m_salani)NephMadness 2020: Green Nephrology Region (https://ajkdblog.org/2020/03/13/nephmadness-2020-green-nephrology-region/)NephMadness 2020: The Time for Nephrologists to Tackle Climate Change is Now (https://ajkdblog.org/2020/04/03/nephmadness-2020-the-time-for-nephrologists-to-tackle-climate-change-is-now/)Links from the Show:03:57 Waste associated with hemodialysis treatments  (https://pubmed.ncbi.nlm.nih.gov/25440109/)04:31 Carbon footprint generated by plastic waste in dialysis units (https://pubmed.ncbi.nlm.nih.gov/16191180/)05:34 Pursuing environmentally conscious dialysis  (https://pubmed.ncbi.nlm.nih.gov/25808949/)09:43 Innovative solutions to recycle plastic generated from treatments (https://phys.org/news/2017-10-plastic-dialysis-durable-concrete.html)10:56 Climate change and chronic kidney disease (https://pubmed.ncbi.nlm.nih.gov/23002432/)11:10-Association between high temperature and acute kidney injury (https://pubmed.ncbi.nlm.nih.gov/29074166/)12:21 Climate change: A Public Heath Emergency (https://www.npr.org/2021/09/07/1034670549/climate-change-is-the-greatest-threat-to-public-health-top-medical-journals-warn)13:08 Climate related increase in kidney stones (https://pubmed.ncbi.nlm.nih.gov/18626008/)16:22 Solar power assisted dialysis  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280036/)17:02 Incorporating training in environmental sustainability in medical education (https://www.nature.com/articles/s41581-020-00353-8)21:07 The ISN Green Nephrology Initiative (https://www.theisn.org/blog/2022/09/05/the-isn-elp-program-2022-cohort-on-climate-change-and-the-urgent-need-for-green-nephrology/) 

On Episode 9, guests Dr. Mitchell Lunn (twitter.com/mitchelllunn) and

On Episode 8, guests Dr. L Parker Gregg (https://us8.admin.mailchimp.com/campaigns/twitter.com/lparkergregg1) and patient advocate Nichole Jefferson (https://us8.admin.mailchimp.com/campaigns/twitter.com/nicholejeff) join us for a conversation about the importance of mental health in patients with kidney disease. Nichole shares with us the importance of attention to mental health and her journey from hemodialysis to peritoneal dialysis to 2 kidney transplants. We also discuss recent and upcoming research in this area. Links from the Show:04:05:  Rates of depression among patients with kidney disease (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720531/)06:10:  National estimates of mental health needs among adults with chronic kidney disease (https://www.kireports.org/article/S2468-0249(22)01366-3/fulltext)06:41: The overlap of uremia and depression (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302619/)09:28: The transition from dialysis to transplant (https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-191)13:48: The CAST trial: effect of sertraline in patients with chronic kidney disease (https://jamanetwork.com/journals/jama/fullarticle/2661489)14:42: The ASCEND trial: cognitive behavioral therapy vs sertraline in patients on hemodialysis (https://pubmed.ncbi.nlm.nih.gov/30802897/)17:46: Adverse effects associated with antidepressant use in patients with chronic kidney disease (https://academic.oup.com/ndt/article/27/10/3736/1828096)21:16: Resources for support for patients with kidney disease (https://www.kidney.org/peers)23:06 CONCORD study (https://clinicaltrials.gov/ct2/show/NCT04422652): Combination of Novel Therapies for CKD Comorbid Depression (https://clinicaltrials.gov/ct2/show/NCT04422652)