Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics Dr. Kara Fitzgerald

Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity.


In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF


Check out our show notes https://www.drkarafitzgerald.com/fxmed-podcast/


Guest information
Anurag Singh, MD, PhDChief Medical Officer at Timeline


Thank you to our sponsor

Timeline
Mitopure
Research from Timeline
care@timeline.com

Timeline Discount for New Frontiers Listeners
Timeline is offering DrKFs readers a 10% discount on Timeline products. Head over to Timeline and use the code KARA10 at checkout.


Show Notes

Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity https://tinyurl.com/y3c2ypkw

Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55>= Years Old...https://tinyurl.com/bdzfccr8

Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults https://tinyurl.com/2p9pjpxc

Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance https://tinyurl.com/2jkhmu9w

Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis https://tinyurl.com/mvrjxxsm

Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial https://tinyurl.com/fscfdd85

Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population https://tinyurl.com/e6npdvyp

Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials https://tinyurl.com/2m2nzd56

Dr. Sandison confesses that when she first heard Dr. Dale Bredesen talk about his work reversing cognitive decline and Alzheimer's disease she was skeptical. But when she started to apply the Bredesen principles in her clinical work and saw just how meaningful the improvements were to patients' symptoms and quality of life, as she puts it: "...how do I do anything else with my life, but basically tell as many people who will listen that this is possible?" She then went on to found the first two residential care facilities for individuals with cognitive decline that are based on the Bredesen approach. She's published research on her clinical outcomes and is continuing to gather more data for publication. The information and inspiration she shares are relevant to anyone dealing with cognitive decline, caring for someone with cognitive decline, or even those of us who want to preserve and optimize cognitive function as we move through life. I found her report that environmental toxins were one of the most common findings among her patient population illuminating. - DrKF

Head to https://www.drkarafitzgerald.com/fxme... for the transcription and all the resources.


Guest information


Dr. Heather Sandison, ND, Author Reversing Alzheimer’s
https://www.drheathersandison.com/
Email: drheathersandisonnd@gmail.com


Thank you to our Sponsors


Diamond
Rupa Health - https://tinyurl.com/yc26f6sj
Biotics Research - https://www.bioticsresearch.com/
Integrative Therapeutics - https://tinyurl.com/47sfktzb
Gold
OneSkin - https://tinyurl.com/ycxvz5we
Mira - https://tinyurl.com/3pj4t338
TimeLine Nutrition - https://tinyurl.com/4bsdfczz
Midroll
Practice Better - Start your free trial and save 20% for 4 months on any paid plan with code KF20 - https://sites.practicebetter.io/new-f...


Show Notes


Reversing Alzheimer's by Dr. Heather Sandison :https://tinyurl.com/3hcywxxv
Dr. Dale Bredesen: https://www.apollohealthco.com/dr-bre...
Montreal Cognitive Assessment (MoCa): https://mocacognition.com/
Marama Residential Care Facility: https://www.maramaexperience.com/
Study: Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline: https://www.ncbi.nlm.nih.gov/pmc/arti...
Study: Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project: https://www.ncbi.nlm.nih.gov/pmc/arti...


DrKF Resources


Podcast: Addressing Root Causes of Neurodegenerative Diseases with Dr. Dale Bredesen: https://tinyurl.com/3f2jchcm
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-...
Younger You Group Program: https://www.drkarafitzgerald.com/youn...

Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF



Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for all the full transcription and all relevant links and resources.


Guest information


Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift.
Email: greg@neurohacker.com
Facebook: https://www.facebook.com/neurohackercollective
Instagram: https://www.instagram.com/neurohacker/
LinkedIn: https://www.linkedin.com/in/gregory-kelly-98b96b138/


Qualia Discount for New Frontiers Listeners

If you’re in your late 20’s or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to https://tinyurl.com/3zpsaw3s for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase.


Show Notes


Dr. Gregory Kelly: https://neurohacker.com/people/greg-kelly
Neurohacker Collective: https://tinyurl.com/3zpsaw3s
Shape Shift: https://tinyurl.com/3zpsaw3s
Alternative Medicine Review: https://tinyurl.com/56ad9av9

OMEMI Trial - https://pubmed.ncbi.nlm.nih.gov/33191772/
REDUCE-IT Study - https://clinicaltrials.gov/study/NCT01492361
ASCEND Study - https://ascend.medsci.ox.ac.uk
VITAL Study - https://www.vitalstudy.org/
Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - https://tinyurl.com/2p85yx5f



DrKF Resources

Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-clinic/our-services/

Bio Age Lab Test: https://youngeryouprogram.com/bio-age-lab-test/

Bio Age Self Assessment Quiz: https://youngeryouprogram.com/basa/

Younger You Group Program: https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/

Younger You book: https://youngeryouprogram.com/book/

I'm excited to welcome Dr. Barry Sears, the renowned creator of the Zone Diet and a pillar in our field. Dr. Sears has not only authored bestsellers but has also made incredibly important contributions to clinical practice which we still rely on today: He is, for instance, the scientist who put the use of the AA:EPA ratio on the map. Dr. Sears provides elegant and accessible explanations of the unassailable importance of diet in addressing inflammation, metabolic health, chronic disease, and longevity, and the role that fatty acids play in that milieu. And while he and I might not agree that polyphenols need to be absorbed intact for benefit - there's plenty of evidence that their postbiotic products are very important players, especially in their interactions with the epigenome - his concerns about the chemical structure of highly concentrated fish oil supplements (with the potential for isomerization, as he argues) has opened my eyes and is important, without doubt. I think the jury is still out as to whether there is a negative influence of isomerization in highly concentrated EPA and DHA, but it's worthy of further investigation and (importantly) is another factor in the argument for a whole-food approach. - DrKF


Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.


Guest information


Dr. Barry Sears, President, Inflammation Research Foundation and CEO of Zone Labs.Inc.
Email: bsears@drsears.com
Website: http://www.drsears.com/
Zone Living Website: http://www.zoneliving.com/
Inflammation Research Foundation: http://www.inflammationresearchfoundation.org/


Thank you to our Sponsors


Diamond
Rupa Health - https://tinyurl.com/yc26f6sj
Biotics Research - https://www.bioticsresearch.com/
Integrative Therapeutics - https://tinyurl.com/47sfktzb
Gold
OneSkin - https://tinyurl.com/ycxvz5we
Mira - https://tinyurl.com/3pj4t338
TimeLine Nutrition - https://tinyurl.com/4bsdfczz
Midroll
Practice Better - Start your free trial and save 20% for 4 months on any paid plan with code KF20 - https://sites.practicebetter.io/new-frontiers-in-functional-medicine


Show Notes


Dietary Control of Inflammation and Resolution - https://tinyurl.com/vadkjzf7
The STRENGTH trial - https://tinyurl.com/282cz27m
OMEMI Trial - https://pubmed.ncbi.nlm.nih.gov/33191772/
REDUCE-IT Study - https://clinicaltrials.gov/study/NCT01492361
ASCEND Study - https://ascend.medsci.ox.ac.uk
VITAL Study - https://www.vitalstudy.org/
Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - https://tinyurl.com/2p85yx5f

Gear up for an enlightening dive with Dr. Tara Harding, a vanguard in the realm of women’s health and fertility. Renowned for her exceptional work as a family nurse practitioner and fertility coach, Dr. Harding brings a wealth of knowledge from her battle against infertility and medical gaslighting, all while breaking barriers and fostering a supportive community for those navigating the complex journey of infertility. This conversation not only highlights innovative diagnostic tools like Mira but also delves into the nuances of managing conditions like PCOS and endometriosis. Dr. Harding’s personal and professional journey is a beacon of hope and empowerment, underscoring the significance of comprehensive care in women’s health. Prepare to be inspired by her dedication to revolutionizing fertility care and advocating for patient empowerment. ~DrKF

Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

Fellow clinicians, get ready for a mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. And being able to test the response of our treatments (and importantly, the synergistic response of multimodal interventions). It’s heady stuff, but amazingly, it is where we are headed today.

Dr. Price illustrates the incredible potential this technology brings for personalized evidence-based medicine, such as tailoring interventions based on microbial markers or targeting specific lifestyle changes for Alzheimer's prevention. The podcast is a captivating exploration of cutting-edge concepts and provides a glimpse into the exciting future of healthcare. I was wowed by my conversation with Nathan and can’t wait to start kicking the tires on this baby. I know you’ll feel the same. ~DrKF

Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.