250 episodes

Die Universitätsbibliothek (UB) verfügt über ein umfangreiches Archiv an elektronischen Medien, das von Volltextsammlungen über Zeitungsarchive, Wörterbücher und Enzyklopädien bis hin zu ausführlichen Bibliographien und mehr als 1000 Datenbanken reicht. Auf iTunes U stellt die UB unter anderem eine Auswahl an elektronischen Publikationen der Wissenschaftlerinnen und Wissenschaftler an der LMU bereit. (Dies ist der 18. von 22 Teilen der Sammlung 'Medizin - Open Access LMU'.)

Medizin - Open Access LMU - Teil 18/22 Ludwig-Maximilians-Universität München

    • Education

Die Universitätsbibliothek (UB) verfügt über ein umfangreiches Archiv an elektronischen Medien, das von Volltextsammlungen über Zeitungsarchive, Wörterbücher und Enzyklopädien bis hin zu ausführlichen Bibliographien und mehr als 1000 Datenbanken reicht. Auf iTunes U stellt die UB unter anderem eine Auswahl an elektronischen Publikationen der Wissenschaftlerinnen und Wissenschaftler an der LMU bereit. (Dies ist der 18. von 22 Teilen der Sammlung 'Medizin - Open Access LMU'.)

    Kommentierter Auszug aus "Die Familie Vorster. Die Geschichte eines deutschen Papiermachergeschlechtes". Bearbeitet von Ferdinand Vorster, Hagen, in den Jahren 1929 – 1936

    Kommentierter Auszug aus "Die Familie Vorster. Die Geschichte eines deutschen Papiermachergeschlechtes". Bearbeitet von Ferdinand Vorster, Hagen, in den Jahren 1929 – 1936

    Verzeichnis der wissenschaftlichen Arbeiten

    Verzeichnis der wissenschaftlichen Arbeiten

    Rahlenbeck: Malörchen im Haus von Grütern zu Altendorf, Aufschwung der Textilherstellung in Hagen und Lumpenkrieg zwischen den Vorsterschen Papiermühlen in Delstern und Eilpe

    Rahlenbeck: Malörchen im Haus von Grütern zu Altendorf, Aufschwung der Textilherstellung in Hagen und Lumpenkrieg zwischen den Vorsterschen Papiermühlen in Delstern und Eilpe

    Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

    Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

    Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression. However, the blinded use of placebo has been found to influence clinical trial outcomes and may bias patient
    selection.
    Discussion: To improve clinical trial design in major depression so as to reflect clinical practice more closely we propose to present patients with a balanced view of the benefits of study participation irrespective of their assignment to placebo or active treatment. In addition every participant should be given the option to finally
    receive the active medication. A research agenda is outlined to evaluate the impact of the proposed changes on the efficacy of the drug to be evaluated and on the demographic and clinical characteristics of the enrollment fraction with regard to its representativeness of the eligible population.
    Summary: We propose a list of measures to be taken to improve the external validity of double-blind, placebocontrolled trials in major depression. The recommended changes to clinical trial design may also be relevant for other psychiatric as well as medical disorders in which expectations regarding treatment outcome may affect the
    outcome itself.

    Kommentare und Quellen zu Abbildungen in Weigl, Lorenz 'Chronik einer Klinik. Von der Gebärstube zur ersten Frauenklinik der Universität München'

    Kommentare und Quellen zu Abbildungen in Weigl, Lorenz 'Chronik einer Klinik. Von der Gebärstube zur ersten Frauenklinik der Universität München'

    Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data

    Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data

    Background: For several immune-mediated diseases, immunological analysis will become more complex in the future with datasets in which cytokine and gene expression data play a major role. These data have certain characteristics that require sophisticated statistical analysis such as strategies for non-normal distribution and censoring. Additionally, complex and multiple immunological relationships need to be adjusted for potential confounding and interaction effects.
    Objective: We aimed to introduce and apply different methods for statistical analysis of non-normal censored cytokine and gene expression data. Furthermore, we assessed the performance and accuracy of a novel regression approach in order to allow adjusting for covariates and potential confounding.
    Methods: For non-normally distributed censored data traditional means such as the Kaplan-Meier method or the generalized Wilcoxon test are described. In order to adjust for covariates the novel approach named Tobit regression on ranks was introduced. Its performance and accuracy for analysis of non-normal censored cytokine/gene expression data was evaluated by a simulation study and a statistical experiment applying permutation and bootstrapping.
    Results: If adjustment for covariates is not necessary traditional statistical methods are adequate for non-normal censored data. Comparable with these and appropriate if additional adjustment is required, Tobit regression on ranks is a valid method. Its power, type-I error rate and accuracy were comparable to the classical Tobit regression.
    Conclusion: Non-normally distributed censored immunological data require appropriate statistical methods. Tobit regression on ranks meets these requirements and can be used for adjustment for covariates and potential confounding in large and complex immunological datasets.

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