The Look Up! Podcast with Marc Weinstein Marc Weinstein

The Most Important ThingThe way we really grow and transcend, become better, people, companies, etc. We have to chase that discomfort, that’s how we get to the next level. 
About GuestEric Pilon-Bignell is a pragmatic futurist and the best-selling author of “Surfing Rogue Waves”, a book that discusses the constant anomaly of change and how humanity is pushed to navigate through this exponential pace of disruption.
About “Surfing Rogue Waves”“Surfing Rogue Waves” presented the idea of Disruption as a means of moving forward in the future rather than being overtaken by the “Waves”. In this book, Eric shares how we could shape our life and the future of humanity with our decisions amidst change.
Episode OverviewIn this episode, Eric and I discuss the future and the fear it brings for most humans. We touch on certain emerging world conflicts and how we can engage with change at such a massive scale. We exchanged views of the world, happiness, and how we think it will progress after the changes that the pandemic brought.
My Favorite Quotes:“We can't put a pin on any one of these because these waves are coming all over, but that kind of equal excitement and fear. I feel that’s where I’m at, I’m so excited about this, there's gonna be so many incredible things.”
“My ego was “how do I always do more, how do I increase my peak performance?”
“I'm getting my ass kicked on small waves. Right. But, but I'm in the zone. Like I'm locked in, I'm paddling, I'm focused, everything changes. I'm like, I'm intense and it's this really cool mix which we have in life.”
“Happiness is how hard it is for you to achieve what you want to get."
Episode Breakdown:04:03 - Writing the book during Covid-19 Lockdown
05:37 - Eric looking back through his journey, life aspirations, and changes
07:35 - Perspective of the future, curiosity and what it could bring
14:30 - “A lot of our old fears are almost like, I guess the buzz word, like fake fears now.” The definition of fear in a modern age, violence, famine, etc
20:30 - The inequality of wealth and its history in relation to happiness
27:40 - South Korea, plastic surgery and the scale of happiness
32:25 - The Fourth Industrial Revolution and technological transformation, to do or to die
44:38 - What is happiness to Eric?
Episode LinksEric's InfoWebsite 
LinkedIn
Facebook
Twitter
Project7
Episode ReferencesSurfing Rogue Waves by Eric Pilon Bignell
Vaccine war in the US
3D printing organs
Future-Proofing workspace and digital transformation
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Editors note: This is part 2 of our 2 part episode with Professor Jack Feldman, don’t forget to catch our first episode here. 
The Most Important ThingWe continue our conversation with Professor Jack Feldman on how he revolutionized our understanding of the neural control of breathing. We dived deeper into the topic of breathing and how it has the ability to change our emotional state. I also get to run a few yoga teachings on the breath by Jack to see how they align (or don’t) with his scientific understanding.
About the GuestJack Feldman is a distinguished Professor of Neurobiology, he also holds a Ph.D. in Physics and is currently teaching at UCLA. 
His contributions to understanding the mechanisms of breathing and sighing include the pre-Bötzinger complex and demonstrating the essential role in generating respiratory rhythm in fetal, neonatal, and adult mammals. Jack Feldman’s influence is evident in numerous highly cited reviews, textbooks, and lectures. He was awarded the prestigious Hodgkin, Huxley, Katz Prize of The Physiological Society.
Episode OverviewIn part two of this episode, Professor Jack Feldman shared his thoughts on living through the polio epidemic and broke down of the importance of a vaccine. Besides that, he also shared how his study finds that breathing could affect cognitive functions positively.
Jack also took a few moments to highlight the differences in breathing between animals and humans in this episode.
My Favorite Quotes“I've been wearing a seatbelt for ever since they became available. I've yet to get in a serious car accident. So you could argue why bother wearing a seatbelt? Well, you wear a seatbelt because the consequences of the rare possibility you get in an accident.”
“if you weigh that against the possibility that the vaccine does something negative right now, that data is extremely small. I wouldn't say zero. It's extremely small. And certainly if the odds are 99.999999 in favor.”
“One of the ways that the brain consolidates it's information is then when things repeat, it strengthens the connections between neurons.”
“If you're less anxious, you're likely to have a longer lifespan if you could maintain it.”
“When we think about how breath could be influencing higher function, cognition, or emotion, the signals that are related to breathing can arrive in the brain by a variety of pathways. Every time you expand your lungs, there are receptors in your lungs that become activated. They send signals up into the brainstem, through the vagus nerve.”
Episode Breakdown (Part 1)05:10 - Jack’s recollection of the Polio endemic 
08:30 - Touching on vaccines and Covid-19
13:00 - Neuro scientist on brain functions
27:30 - Thoughts on elogating breathing extending lifespans 
34:38 - How breathing affects our mental states
44:30 - Something that Jack still finds surprising from his research
48:06 - A research that Jack personally wants to test
Episode LinksProfessor Jack Feldman’s Info
Jack Feldman - Instagram
Jack Feldman - LinkedIn
Jack’s scientific journals - Google Scholar 
Jack Feldman’s UCLA Profile and Publications
References made in the episode
The Science of Breath, Swami Rama
Box Breathing Technique
Light on Yoga, BKS Iyengar
Overview of Nadi Channels
Alternate Nostril Breathing
Marc’s Info
Look Up! Patreon Community
Look Up! Website
Marc's Instagram
Marc's Twitter
Look Up! On iTunes
Look Up! On Spotify
Support this show http://supporter.acast.com/the-look-up-podcast-with-marc-weinstein.

Hosted on Acast. See acast.com/privacy for more information.

The Most Important ThingHow can something as simple as breathing impact our health and optimize performance? Famous for his breakthrough contributions within the field of breathing, sighing, and discovering the pre-botzinger complex. Jack Feldman takes us through almost four decades of his career, researching and discovering a process we all take for granted, breathing. 
About the GuestJack Feldman is a distinguished Professor of Neurobiology, he also holds a Ph.D. in Physics and is currently teaching at UCLA. 
His contributions to understanding the mechanisms of breathing and sighing include the pre-Bötzinger complex and demonstrating the essential role in generating respiratory rhythm in fetal, neonatal, and adult mammals. Jack Feldman’s influence is evident in numerous highly cited reviews, textbooks, and lectures. He was awarded the prestigious Hodgkin, Huxley, Katz Prize of The Physiological Society.
About “what Jack Feldman does”Professor Feldman’s laboratory focuses on the central problem confronting neuroscientists: how molecular, synaptic, and cellular properties of individual neurons in densely interconnected networks result in behaviors ranging from playing the piano to writing a book. Through a unique model system that enables them to perform studies that address this issue, Feldman and his colleagues are able to test their current hypothesis: pacemaker neurons underlie the generation of respiratory rhythm
Episode OverviewIn part one of this episode, we got to speak to Professor Jack Feldman about his research into the field of breathing, sighing, and developing the Pre-Botzinger Complex. Jack broke down his journey of how he got into the research, conducting crazy experiments and took almost a decade trying to convince people of the importance of breaths.
Jack also took a few moments to highlight how a study into brain stems kickstarted his interest in the topic of the brain breath connection.
My Favorite Quotes“You can't do anything interesting if you're afraid of failing and I'm willing to bet that that's something that people in your realm also follow.”
“You make investments, but some of the best investments are the things that might ultimately fail, but they could be spectacular.”
“One of the challenges in science is that the technology progresses and sometimes the technology allows you to answer questions that are very important. You can answer before. The problem with that is that we're under a lot of pressure as scientists to keep producing. And when a new technique comes along, you have to learn it sometimes have to spend a lot of money to get the equipment necessary to do that and that the tracks, your productivity.”
“Just like your car has one engine. We thought there would be a single-engine for breathing. We discovered about 15 years later that there appears to be a second engine and one engine is devoted to generating the inspiratory rhythm and the other is involved in generating rhythm.”
“I realized that the literature was just simply wrong and we embarked upon a series of crazy experiments to try and see if we could localize a site for generating breathing. I wouldn't say much to my surprise that we identified a relatively small spot in the brainstem that seemed to be critical for the generation.”
“You have to be resilient and you have to be persistent. At some point, you have to believe that you have an idea that's worth pursuing. ”
“You have to be careful where you become too much of a believer in an idea because things often, even good ideas get overturned as science progresses, and you have to be able to recognize it.”
Episode Breakdown (Part 1)03:17 - Jack’s most surprising discovery about brain + breath connection
08:30 - Closely held belief of how breath was generated
16:51 - When and why Jack started researching breathing
20:40 - How the study of breathing came about 
33:00 - How a scientific peer review could make or break an experiment or theor

The Most Important ThingHow does one break away from their Mormon roots, become a millionaire, and lose it all at a very young age just to pick it right back again. Doug talks to us about his journey of reinventions and how changing his perspective in life has brought back positivity in his life.
About the GuestDoug Cartwright is the Founder and CEO of The Daily Shifts, an online platform committed to lifelong transformation of the mind, body, and soul. Drawing from his personal experience of introspection and healing, The Daily Shifts is now an app, a master class, and blog that challenges you to be the best version of yourself.
His new book “Holy Sh!t We’re Alive?” taps into his life story. A psychedelic journey into meditation, silent retreats, astrophysics, neuroscience, philosophy, and all forms of self-healing.
About “Holy Sh!t We’re Alive?”“Holy Sh!t We’re Alive?” is the story of a psychedelic-sparked spiritual journey of an ex-Mormon millionaire. In this book, Doug broke down his journey into meditation, silent retreats, philosophy and all forms of self-healing.

Through this journey, he learnt his mistakes, built a new reality and found the purpose of life by shifting his perspective, outlook and beliefs. In Holy Sh!t, We’re Alive, Doug shows you how to live with intention, trust yourself, and show up every day for a meaningful life. You’ll learn mind-blowing facts and important clues to understand your existence and unique contributions. Self-love can be your superpower.
Episode OverviewIn this episode, we got to speak to Doug Cartwright about his book “Holy Sh!t We’re Alive?” and how his business, The Daily Shift, came to be. Doug deconstructs his two year journey into discovering spirituality, faith and the universe around him and how that changed his perspective in life.

We also got to dive deeper into the chapters of his book to get a bigger picture of how and why it was written as is. Doug also took a few moments to highlight the importance of self love, finding faith and letting go.
My Favorite Quotes“A major lesson I learned through it was the beauty of learning to trust my intuition..”
“When we zoom out and just kind of realize that just being alive is the ultimate gift. It really takes the pressure off of our daily routine activities.”
“If you look across the whole universe, there's nothing even remotely close to earth, but all the spots are a little tiny speck. We got dropped down here and it was like this really wow moment. 
“It's easier to be told by others what to think and to think for yourself. And it requires, you know, it, to be so vulnerable and kind of wipe your slate clean on. What's true and what's not true. Then rebuild it yourself.”
“I'm truly committed to the higher path, to the spiritual path, to truly evolving my soul, to becoming the best version of myself.”
“As long as I continue to put my best effort into the world, the universe will take care of me.”
“Intuition is a tricky concept that you can’t measure. It’s this weird feeling, almost like a deep knowing feeling. But when you realize it and it opens up to you, you know you’re doing the right thing.”
Episode Breakdown05:28 - Trusting one’s intuition
08:40 - Doug thinking back at his previous job and the stress that follows
10:20 - Doug’s experience during the Ayahuasca ceremony
13:44 - Views of life and how every experience is an opportunity
17:45 - Turning a traumatic experience into a life-changing lesson
23:11 - Envy, jealousy and desires in a relationship
31:17 - To love yourself is to remove pieces that doesn’t fit anymore
37:00 - Doug’s view on philosophy and why he decided to write his book
41:25 - Managing expectations through gratitude
43:16 - How is success and happiness measured? Doug explained
47:14 - Growing up Mormon and leaving the religion
54:00 - Finding instant connection within a community
58:28 - Doug’s take on being committed to a h

The Most Important ThingThese days, manufacturing comes with numerous barriers: economic, environmental, and social. Ben talks to us about how Cellibre is revolutionizing the industry using “cellular agriculture” making supply chains efficient and affordable, and prioritising sustainability. 

About the GuestIn his own words, Benjamin “Ben” Chiarelli is a “founder, investor, adviser, and connector.” Over the past decade, he has worked as a healthcare investment banker for the country’s biggest names, including Deloitte, Jefferies & Company, and J.P. Morgan. He has also been at the helm of teams at Millennium Health, ASCA Design LLC, and Synthetic Genomics, alongside working under movers and shakers in the science world. 
Drawing from his experience with healthcare investment banking, Ben has founded two of his own companies: private equity firm Divitempus Ventures, as well as cellular agriculture Cellibre.

About CellibreFounded in 2017, Cellibre develops cellular agriculture solutions for products that have traditionally had issues scaling production in a sustainable, economic, and high-quality way. Utilising the science of synthetic biology, Cellibre changes and optimizes the cells that produce the target natural product. 
The cellular agriculture company has pioneered breakthroughs in energy, ingredients, medicines, and more. Their current focus is to use their expertise in the production of pharmaceutical-grade cannabinoids, revolutionizing the way cannabinoid-based medicines are sourced, produced, and consumed.

Episode OverviewIn this second half of our chat with Ben, we pick his brain about Cellibre, sustainability, and manufacturing technology that is revolutionizing the industry. Ben deconstructs the science behind cellular technology, particularly as it pertains to cannabinoids. Comparing it to computing, we also talked about the future of technology, genetics, and our instinct for adaptation. 
With expectations for Cellibre to go commercial later this year, Ben also takes a few moments to highlight the importance of work-life balance, putting people over the company, and how radical it is to have empathy for others.

My Favorite Quotes“We have big visions of reinventing how we make things as humanity.”
“Don’t think that you have to conquer the world every single day.”
“We think about these things (sustainability) really superficially. So, if you think about what nature is, and more fundamentally, what biology is, it’s the world’s most elegant manufacturing tech.”
“If you’re thinking about policy, or you’re thinking about business, try and think about it from the perspective of the person who has the least […] Think about it from the perspective of the guy in rural America or the kid in the inner city.”
“I want to be able to deconstruct and reconstruct nature in a way that’s sustainable, where we’re not going into the ecosystem to provide human beings with benefit.”
“How do we leverage nature to actually keep us sustainable, while at the same time, keeping the planet healthy?”
“I always want to help. I always want to get an answer, but sometimes there’s just not one.”

Episode Breakdown03:54 - Surrounding yourself with knowledgeable people
07:02 - Connecting the technical with the business; hiring people with expertise
10:11 - Ben’s role at Cellibre as its founder
13:30 - Being a father and a founder: managing time and expectations, and being present
18:45 - Going beyond a superficial understanding of sustainability
24:11 - Decoding the astounding complexity of cannabis plants
26:47 - The state of technology, minimal cells, and the requirements for life
29:42 - Making supply chains more efficient, affordable, and sustainable at Cellibre
32:35 - Prioritising the accessibility of their product
35:16 - Facing legal barriers, focusing on CBG and CBD, and going commercial
37:04 - The limitless possibilities of cannabinoids
42:17 - Being adaptable and the

The Most Important ThingWhat is it for you that sparks joy? To Ben Chiarelli, it’s the act of connecting one person to another, adding value to each of their lives. Today, Ben reveals just how central relationship-building has been to both his career and life.

About the GuestIn his own words, Benjamin “Ben” Chiarelli is a “founder, investor, adviser, and connector.” Over the past decade, he has worked as a healthcare investment banker for the country’s biggest names, including Deloitte, Jefferies & Company, and J.P. Morgan. He has also been at the helm of teams at Millennium Health, ASCA Design LLC, and Synthetic Genomics, alongside working under movers and shakers in the science world. 
Drawing from his experience with healthcare investment banking, Ben has founded two of his own companies: private equity firm Divitempus Ventures, as well as cellular agriculture Cellibre.

About CellibreFounded in 2017, Cellibre develops cellular agriculture solutions for products that have traditionally had issues scaling production in a sustainable, economic, and high-quality way. Utilising the science of synthetic biology, Cellibre changes and optimizes the cells that produce the target natural product. 
The cellular agriculture company has pioneered breakthroughs in energy, ingredients, medicines, and more. Their current focus is to use their expertise in the production of pharmaceutical-grade cannabinoids, revolutionizing the way cannabinoid-based medicines are sourced, produced, and consumed.

Episode OverviewThis week, Ben takes us on a decade-long journey through his career as an investment banker; how it exposed him to some really innovative people and taught him the value of relationship-building. We see how distinctly those formative years shaped Ben’s interests and practices, particularly with his latest endeavour into the cannabis industry.
In this first part, we delve into Ben’s ability to give altruistically and his innate love for creating connections, even if it means replying to LinkedIn messages past midnight. We also touch on synthetic biology, reciprocity, and what it means to live in a global village.

My Favorite Quotes“Our society is kind of dominated by tech, right? […] But the real next industrial revolution is biology.”
“I think the legacy of real relationships, real connections is infinitely more valuable than a dollar.”
“Being responsive is really just a reflection of being cognizant that someone’s time is the most important thing they have. And they’re trying to allocate that time to maximise their happiness.”
“A lot of human beings have trouble giving credit to others. People tend to have an overinflated view of self.”
“For me, it was much less about being my own boss, and being an entrepreneur, and being held on a pedestal, just more, this is a good idea and we’re going to help a lot of people with this.”
“No matter where you go, you’ll meet really interesting people.”

Episode Breakdown00:51 - Introduction
05:46 - Ben’s foray into investment banking and experiencing culture shock
10:13 - Connecting with Dr. Craig Venter, who sequenced the first human genome
11:48 - Biology as a manufacturing technology and its impact on society
13:44 - Shifting to the cannabis sector after hearing of its medicinal qualities
15:57 - The value of investment banking: learning to add value to your clients
19:17 - What does being a “connector” mean to Ben?
24:43 - The psychology of reciprocity and giving altruistically
28:11 - Ben’s biggest pet peeve: lack of responsiveness 
31:19 - Living in a global village and the joy of bringing people together
36:14 - Legacy as compensation and giving credit where credit is due
40:49 - Growing something tangible out of ideas
42:58 - Prioritising helping others over the glamour of being an entrepreneur
44:54 - Meeting fascinating people in the cannabis space
49:30 - Outro

Episode LinksBen’s Info
Ben’s LinkedIn
Cellibre Websit