DiabetesBio American Diabetes Association

Welcome to the April 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2024 issue of Diabetes. 
2:55: To kick things off, Darleen and Kirk are joined by Dr. Sebastian Kalamajski (Lund University), senior author of “Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function.” This article can be freely accessed at https://doi.org/10.2337/db23-0531.
15:16: Darleen and Kirk chat with Dr. Yuval Dor (The Hebrew University of Jerusalem), senior author of “DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets.” This study can be freely accessed at https://doi.org/10.2337/db23-0704.
42:50: Darleen introduces a very special guest for this month’s Sweet Talk, Dr. Carmella Evans-Molina. She is the director of the Center for Diabetes and Metabolic Diseases at Indiana University School of Medicine, and she was awarded the 2023 Outstanding Scientific Achievement Award by the American Diabetes Association. Darleen and Kevin raise many topics in this conversation with Dr. Evans-Molina, from her focus on the role of calcium in regulating insulin secretion to the importance of serendipity and collaboration in scientific research to her recent hobby of learning to play the piano. 
To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the special Sweet Talk March 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. Our host is Dr. Kevin Williams. 
 1:00 Sweet Talk, part 1. Kevin introduces the guests for the first part of Sweet Talk, Dr. Christopher Newgard from Duke University Medical Center and Dr. Louis Philipson from the University of Chicago School of Medicine. They are co-chairs of the American Diabetes Association’s Pathway to Stop Diabetes Mentor Advisory Group. The Pathway program seeks to identify and support exceptional young scientists in the field of diabetes research. Drs. Newgard and Philipson explain the history of the program, expand on the importance of mentorship for young scientists, and relate challenges faced by the program, from funding cuts to the COVID-19 pandemic. 
18:56 Sweet Talk, part 2. To wrap up the episode, Kevin brings in Dr. Céline E. Riera, recipient of a Pathway to Stop Diabetes initiator award in 2015. Dr. Riera is the author of a thought-provoking Perspective article in the March 2024 issue of Diabetes that is based on her award-winning research. This article can be freely accessed at https://doi.org/10.2337/db23-0706. 
To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the March 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2024 issue of Diabetes. 
1:15 Before getting underway with this week’s interviews, Kirk gives a quick shout-out to March’s Paper of the Month: “High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans,” by Gray et al. Although they only mention it in passing, Kirk does offer a ringing endorsement: “It’s excellent work, and all things glucagon are good.” This article is freely available at https://doi.org/10.2337/db23-0201. 
 2:44 Darleen announces that the March DiabetesBio is actually two episodes. The first part features Darleen and Kirk interviewing authors of the feature articles of the month, and the second part is devoted to Sweet Talk with Kevin. In this special episode, Kevin delves into the ADA’s Pathway to Stop Diabetes initiative with two of the initiative’s key members and one of the initiative’s award-winning researchers. 
 4:30 Darleen and Kirk interview Mr. Harry B. Cutler and Dr. David E. James, first and last authors of “Dual Tracer Test to Measure Tissue-Specific Insulin Action in Individual Mice Identifies In Vivo Insulin Resistance Without Fasting Hyperinsulinemia.” They discuss the use of a dual tracer test and describe insights into tissue-specific insulin action. They also raise an interesting question: Could it be that the popular belief that peripheral insulin resistance leads to hyperinsulinemia is inaccurate? This article can be freely accessed at https://doi.org/10.2337/db23-0035. 
 27:50 Kirk and Darleen then host Dr. Lori Sussel, last author of “PTPN2 Regulates Metabolic Flux to Affect β-Cell Susceptibility to Inflammatory Stress.” Dr. Sussel and her group determined that β-cells lacking PTPN2 are more susceptible to inflammatory stress associated with T1D due to impaired glucose-stimulated insulin secretion, mitochondrial defects, and reduced glucose-induced metabolic flux, indicating a role for PTPN2 in maintaining metabolic fitness in β-cells. This article can be freely accessed at https://doi.org/10.2337/db23-0355. 
To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the February 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2024 issue of Diabetes. 
2:25: To kick things off, Darleen and Kirk are joined by Dr. Satya Dash of University Health Network and the Banting & Best Diabetes Centre, University of Toronto. Dr. Dash is the senior author of “Erythritol as a Potential Causal Contributor to Cardiometabolic Disease: A Mendelian Randomization Study.” Do low-calorie sweeteners possibly contribute to cardiometabolic disease? Listen to hear about the results of Dr. Dash’s study. This article can be freely accessed at https://doi.org/10.2337/db23-0330. 
14:52: Next, the Big 10 is well represented when Darleen and Kirk meet with Drs. Jeffrey Hodgin (University of Michigan) and Alan Attie (University of Wisconsin) to discuss their fascinating collaboration on their “Genetic Analysis of Obesity-Induced Diabetic Nephropathy in BTBR Mice.” Drs. Hodgin and Attie’s study can be freely accessed at https://doi.org/10.2337/db23-0444. 
36:51: Sweet talk! Kevin introduces the first installment of the journal’s “Classics in Diabetes” series. This new format brings timeless articles into the spotlight and showcases their value for today’s scientists. The first installment, “GPCR Promiscuity Reshapes Islet Physiology” (https://doi.org/10.2337/dbi23-0014), was co-authored by Diabetes Associate Editor Jonathan Campbell and Frans Schuit and appears in the September 2023 issue of the journal. This commentary explores the work of Dr. Schuit, its implications for the understanding of diabetes, and how it laid the foundation for a rethinking of a traditional role of glucagon. Here, in this enlightening discussion, Dr. Schuit takes us through the historical context that led to the hypothesis and conclusions of his January 1998 classic, “Dual Glucagon Recognition by Pancreatic β-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors” (https://doi.org/10.2337/diab.47.1.66), and Dr. Campbell explains how rediscovering the concepts and findings of Dr. Schuit’s work has informed his current research. Drs. Schuit and Campbell conclude the discussion by sharing their thoughts on glucagon research and diabetes treatment. 
To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the premiere episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In each episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams will discuss the latest and greatest content in Diabetes. The team kicks off this first episode with some brief introductions before passing the mic to Diabetes editor-in-chief David D’Alessio (5:35), who shares his experiences as the editor of the journal and describes new initiatives involving the journal.  
15:35: In addition, Dave and the team discuss the legacy and contributions of Daniel Porte Jr. Dan passed away at the age of 91 in May 2023, and he is the subject of a “Profiles in Progress” remembrance by Steven Kahn et al. in the January 2024 issue of Diabetes: https://doi.org/10.2337/db23-0787.
20:42: Darleen and Kirk then interview Dr. Gregory Steinberg of McMaster University. Dr. Steinberg is the senior author of “Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis.” This article, which can be freely accessed at https://doi.org/10.2337/db23-0495, is the editor-selected Paper of the Month for the January 2024 issue of Diabetes.
31:49: In the “Sweet Talk” segment, Darleen and Kirk wrap up the episode by reviewing several interesting articles in January 2024 issue of Diabetes. Studies highlighted in this segment include:
M.W. Pataky et al. Divergent Skeletal Muscle Metabolomic Signatures of Different Exercise Training Modes Independently Predict Cardiometabolic Risk Factors. https://doi.org/10.2337/db23-0142 K. Motomura et al. Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure. https://doi.org/10.2337/db23-0212  C Jiménez-Sánchez et al. Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release. https://doi.org/10.2337/db23-0205 C.M. Cohrs et al. Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis. https://doi.org/10.2337/dbi20-0018 To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening!