From the Spectrum: Finding Superpowers with Autism Ryan Sumner

In Part 2 of the Excitation and Inhibition phenomena, we discuss Metabolic "bank" account and demands of navigating the social world. We discuss if we have enough resources or if we will run a metabolic deficits (think burnout and avoidance, and social isolation). We cover NMDA and AMPA and different Autistic Phenotypes. In addition, we review Neuromodulators, which are vast in our biology and determine how and where to direct our attention and energy. Lastly, we discuss the medial Prefrontal Cortex and how it integrates the "self" with the outside world.
Don't try to change an Autistic person because they are different than you or different than others. Don't let that offend your beliefs and capacity to apply critical thinking in life.

https://www.nature.com/articles/s41398-023-02317-5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/
https://www.nature.com/articles/s41398-018-0155-1
https://www.nature.com/articles/nature10360
https://onlinelibrary.wiley.com/doi/full/10.1034/j.1601-183X.2003.00037.x?sid=nlm%3Apubmed
https://www.nature.com/articles/s41380-022-01506-w

(0:00) Introduction; Know Autism and Make Informed Decisions; Biological Aspects influencing Excitation / Inhibition Phenomena
(4:30) Metabolic "Bank" Account and Resources; E/I creates criteria A and B; NMDA and AMPA, and more on the Striatum
(10:02) Neuromodulators- Serotonin, Dopamine, Epinephrine and Norepinephrine, Acetylcholine; Active versus Passive Coping; Activating Systems and Cells and influencing Learning and Memory (Neuroplasticity); Nicotinic Receptors and Rapid-Excitation
(15:20) medial Prefrontal Cortex (mPFC)- Metabolic demands and planning while considering Feelings, Integrating the Self and the Outside World; How E/I interacts; a brief explanation on Default Mode Network; Quieting the Body, or not; Information-Processing; Thalamocortical
(20:19) Pursuits and Preference- Wanting and Having and being Autistic is fine, and others need to accept our phenotypes; sensory-input causes Faster Firing Rates in normal E/I- Image an imbalanced E/I
(22:25) Wrap-up and understanding Autism, and Contact Info

In this episode, we discuss the Excitation and Inhibition Phenomena in Autism. There are many biological aspects implicating the E/I balance, and the Nervous System needs a healthy balance. This episode extends slightly downstream of the Genetic and Protein implications previously discussed. We discuss cortical and subcortical areas, sensations, introduce Glutamate and GABA, and discuss the critical period. The critical period is, pardon the pun, a critical period for Autism. In addition, we discuss BDNF and introduce neuroplasticity. Finally, we discuss Melanin and Melanopsin and sunlight and modern light, and the vast implications from our new environment. To end, we connect many modern diseases to these biological factors.

See Dr. Jack Kruse Quantum Engineering 45

Email: info.fromthespectrum@gmail.com

In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary.

Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdf

PTEN and mTOR https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01435-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014358%3Fshowall%3Dtrue

16p11.2, Serotonin, and Possible Social Deficit Rescues
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/
https://www.nature.com/articles/s41586-018-0416-4
https://www.nature.com/articles/s41386-021-01091-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/

Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/

Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/

SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3

Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/
https://www.sciencedirect.com/science/article/pii/S0092867414006734

(0:00) Introduction; Excitation and Inhibition;
(3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should?
(10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help;
(13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch;
(19:24) Back to 16p11.2 and Cortical Development;
(22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability;
(24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination;
(25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC
(29:25) Wrap Up and Contact Information

email: info.fromthespectrum@gmail.com

In today's episode, we discuss Criteria A in the DSM-5-TR, which involves social communication and interaction. We discuss various aspects of the social world including unpredictableness, sensory processing being overwhelmed from the rapid firehose of information, being a student in a classroom, empathy, and are Autistic's being changed instead of cultivated into their own unique gifts (or Superpowers).

Autism and Empathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484273/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804307/

More from CNTNAP-2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/
https://www.cell.com/fulltext/S0092-8674(11)01010-5

Sir Simon Baron-Cohen https://www.psychol.cam.ac.uk/people/simon-baron-cohen
Temple Grandin https://www.templegrandin.com

Deisseroth on Socialness https://www.youtube.com/watch?v=gOWnf1BpkGs

DSM (don't get hitched on this book) https://www.psychiatry.org/psychiatrists/practice/dsm

(0:00) Introduction;

(2:12) A1; don't change others just because; joining conversation; unpredictableness, protection, sensory processing and sounds blending; firehose of information;

(15:11) A2; don't change others just because pt. 2 and ABA therapy; interests are easier for all; challenges in the classroom and mental effort;

(21:09) A3; challenges with play as a child; strict rule adherence; imaginative play, even when good, is bad; fits and tantrums; speech and peers; empathy- emotional versus cognitive- ASD is better at emotional empathy; supplementing relationships later in life with small talk; relationships are hard!

(31:32) Leo Kanner correction- Nervous Child, not Pathology- Pathology section in Nervous Child;

(31:54) Final Thoughts; contact information and reaching out to me

Email- info.fromthespectrum@gmail.com

In this episode, we discuss criteria B from the DSM-5-TR. Criteria B are known as Restricted and Repetitive Behaviors. In addition, we discuss how criteria B implicates criteria A, or the social communication and interaction aspects of Autism.

Projections https://www.amazon.com/Projections-Story-Human-Emotions/dp/B08LDWC2L6/ref=sr_1_4?crid=1GPPI5ZOFM2OS&dib=eyJ2IjoiMSJ9.nkY0ZQ0_m001QwcD7GiPwEwRdZitzaWU2NDjvRw_-xiCyiXLlyVfEZSzmonDa2coKQXiPSas9JLw1NeXBBjVh-I5pYHXvMVnLvB9vFwniO7QRoSLMGL3Idst8j8oqskuyPjy1UlNxZR23U_Ch22UJLU033T0wsMJNyZE6FcDepX8XAZAlXqeWXAHRXYD6jhVQLF771sNzRg3o_tKPJBoDr7GF0TWaaX5Nl7Mynmvvc4.Yfa8m249WY_xvl2E3TGObX7BoDhrJ_nU9R8d0ezWL34&dib_tag=se&keywords=projections&qid=1711134807&sprefix=projections%2Caps%2C100&sr=8-4
Peter Attia and Karl Deisseroth https://youtu.be/4oiKOX2lCmE?si=Ru7W7cPpDDxtE8Qr
Future Treatment possibilities https://youtu.be/eeySrgKev2g?si=IbX5h6qG5ddBPeO5
Leo Kanner https://psycnet.apa.org/record/1943-03624-001
Meet My Autistic Brain Episode https://podcasts.apple.com/us/podcast/meet-my-autistic-brain/id1548001224?i=1000629007371
APA's DSM-5-TR https://www.psychiatry.org/psychiatrists/practice/dsm
(But don't get hitch on this book)

Time Scales
Introduction (0:00)
A Brief History (1:29)
Similar Disorders (or Phenomena) (2:25)
Levels of Autism; Criteria A and B; Superpowers and Superdeficits (5:16)
Criteria B; B1 Stereotyped or Repetitive Motor Movements, Use of Objects, or Speech; Stimming; Echolalia Example (9:40)
B2 Insistence on Sameness, Inflexible Adherence to Routines, or Ritualized Patterns of Verbal or Non-Verbal Behavior; Rigid Thinking Patterns and Gray Areas cause Problems; BEE MOVIE example (16:24)
B3 Highly Restricted, Fixated Interests that are "Abnormal" in Intensity or Focus; Find your Interests and Superpowers and Do That; Vietnam War; Memorization, Accelerated Learning and Personal Example (22:37)
B4 Hyper or Hyperactivity to Sensory Input or Unusual Interests in Sensory Aspects of the Environment; Complications with Eye-Contact and Keeping Up; Sensory Processing Phenomena; Visualization and the Eyes (32:47)