Cellular function lies at the root of all complex and simple biological systems. This course will expose you to the fundamental mechanisms that allow cells to maintain the system of proteins and biomolecules required for them to replicate with high fidelity, to maintain stable functional states, to differentiate in response to external cues and to ultimately form complex organizations of cells (i.e., tissues). We will apply an experimental approach to a classic problem in cell biology. We will master “blackboard” experimental techniques to allow us to explore the remarkable transformation of a monolayer of cells after being “wounded.” Under such conditions, cells surrounding the wound change their organization and programming in order to migrate, divide, and differentiate to fill in the wound.
Lecture 01: Kaplan discusses class mechanics, student questions and the central questions of cell biology.
Goals of Cell Biology
Lecture 02: Goals of cell biologists and the overall course plan are discussed and students introduced to the question of how to study cells.
Lecture 03: This class reviews what characteristics a gene needs to be "necessary and sufficient." A discussion of antibodies and their application to various techniques of cell biologists.
Lecture 04: How to use subcellular fractionation and other techniques to study complex cellular processes and molecules.
Lecture 05: This class wraps up of tools to study complex cellular behavior (including microscopy), and introduces membrane proteins.
Lecture 06: This is a continued discussion of cellular membranes and their various functions in biochemical reactions.
I'm a med student in a pbl schooling environment. These lectures are a great resource to me that clarifies some of the sticky points in my reading. Am enjoying myself listening to these lectures. Thank you for them!