49 episodes

The Go-to Podcast for Biotech Scientists Who Want to Master Bioprocess CMC Development and Manufacturing of Biologics.**TOP 10 LIFE SCIENCES PODCAST**Do you want to simplify bioprocessing so that you can scale with confidence and reduce time to market?Are you sick of feeling overwhelmed by the complexity and guesswork of biologics drug development?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?There’s a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver without delay your groundbreaking therapy to clinics and market, and still enjoy every single step.Hey, I’m David Brühlmann, biotech entrepreneur and consultant, international technology transfer expert, and innovation coach. I’ve been there. And guess what, science may give you headaches, but biologics drug development should not.Want to learn how I and many industry experts did it?- In this podcast, you will learn:- How to develop bioprocesses with peace of mind- How to master biologics drug development- How to deliver your life-transforming therapy to clinics and market fast and efficiently- How to actually enjoy doing all thisI can’t wait to help you do biotech the smart way.Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.Ready? Binge-listen mode: Go!Next Steps:Visit the Website: www.smartbiotechscientist.comEmail us: hello@bruehlmann-consulting.com

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists David Brühlmann: Biotech Entrepreneur & Cell Culture Technology Innovation Aficionado

    • Science
    • 5.0 • 7 Ratings

The Go-to Podcast for Biotech Scientists Who Want to Master Bioprocess CMC Development and Manufacturing of Biologics.**TOP 10 LIFE SCIENCES PODCAST**Do you want to simplify bioprocessing so that you can scale with confidence and reduce time to market?Are you sick of feeling overwhelmed by the complexity and guesswork of biologics drug development?Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commercialization?There’s a way to simplify and streamline so you can remove complexity, skip trials and errors, deliver without delay your groundbreaking therapy to clinics and market, and still enjoy every single step.Hey, I’m David Brühlmann, biotech entrepreneur and consultant, international technology transfer expert, and innovation coach. I’ve been there. And guess what, science may give you headaches, but biologics drug development should not.Want to learn how I and many industry experts did it?- In this podcast, you will learn:- How to develop bioprocesses with peace of mind- How to master biologics drug development- How to deliver your life-transforming therapy to clinics and market fast and efficiently- How to actually enjoy doing all thisI can’t wait to help you do biotech the smart way.Grab a cup of coffee and your favorite notebook and pen. Now is the time to take your bioprocessing game to the next level.Ready? Binge-listen mode: Go!Next Steps:Visit the Website: www.smartbiotechscientist.comEmail us: hello@bruehlmann-consulting.com

    48: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 2

    48: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 2

    Unlock the secrets to cost-efficient antibody therapeutics with Brian Kelley, Senior Vice President of Process Development at VIR Biotechnology.
    In this illuminating episode, industry expert Brian Kelley shares invaluable insights into driving down manufacturing costs while maintaining quality and accessibility. From optimizing batch sizes to maximizing titers, discover practical strategies to streamline the process economics of antibody development.
    Key Takeaways:
    Scale Matters: Learn how economies of scale play a pivotal role in minimizing manufacturing costs, paving the way for global accessibility of life-saving therapies.Titer Triumphs: Dive deep into the significance of maximizing titers to achieve substantial reductions in batch requirements and cost of goods, revolutionizing antibody production efficiency.Focus Innovation: Gain clarity on where to direct innovation efforts, balancing established manufacturing practices with groundbreaking developments in emerging modalities like cell and gene therapies.Join us as we unravel the future landscape of antibody production, where simplicity and innovation converge to shape the next frontier of healthcare solutions. Tune in now for actionable strategies and visionary perspectives on mastering process economics in antibody therapeutics.
    Connect with Brian Kelley:
    LinkedIn: https://www.linkedin.com/in/brian-kelley-3389375
    Next Step:
    Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

    • 18 min
    47: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 1

    47: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 1

    Join us in this enlightening episode as we explore process economics with industry expert Brian Kelley. He is the Senior Vice President of Process Development at VIR Biotechnology.
    Unraveling the mysteries of cost management in antibody therapeutics, Brian sheds light on the intricate challenges faced by biotech scientists and engineers.
    Key Highlights:
    Discover the nuanced interplay between technical and cultural obstacles in process development.Navigate the labyrinth of cost drivers in antibody manufacturing, from raw materials to labor expenses.Learn the art of balancing speed, quality, and cost-effectiveness in bringing therapeutics to market.Tune in for a masterclass in maximizing efficiency and driving down costs in the dynamic landscape of biologics production.
    Connect with Brian Kelley:
    LinkedIn: https://www.linkedin.com/in/brian-kelley-3389375
    Next Step:
    Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

    • 16 min
    46: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 2

    46: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 2

    Dive into the future of food with our latest episode, "From Lab to Table: The Science Behind Cultivated Meat." With our guest, Petra Hanga, a Lecturer in Biochemical Engineering at University College London and Chief Scientific Officer of Quest Meat Ltd., we unravel the secrets behind this groundbreaking technology.
    Key highlights:

    1. Discover how stem cells revolutionize the production of cultivated meat, providing a scalable solution for creating muscle, fat, and connective tissues.

    2. Explore the intricate balance of nutrients, growth factors, and environmental conditions crucial for maximizing cell growth and quality.

    3. Understand the challenges and breakthroughs in scaling up bioreactor processes for efficient meat production.
    Join us for an informative discussion on the cutting edge of food technology. Gain valuable insights into the process of transforming lab-grown cells into delectable dishes on your table.
    Don't miss out on this compelling episode!
    Connect with Petra Hanga:
    LinkedIn: https://www.linkedin.com/in/petrahanga/
    Twitter: @PetraHanga
    Next Step:
    Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

    • 25 min
    45: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 1

    45: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 1

    Dive into the fascinating world of cultivated meat with our guest, Petra Hanga, Lecturer in Biochemical Engineering – Cellular Agriculture at University College London and the Chief Scientific Officer of Quest Meat Ltd.
    In this episode, Petra sheds light on the intricacies of developing cultivated meat and reveals the key hurdles biotech scientists face.
    Highlights:
    Learn how scientists tackle the complexity of replicating animal meat, ensuring a truly authentic taste and texture for future meat alternatives.Gain insight into the innovative solutions shaping the future of sustainable protein sources.Discover the potential of cultivated meat to revolutionize our food system.Join us as we explore the promising landscape of cultivated meat, where science and innovation converge to shape a more sustainable future.
    Enjoy your listening!
    Connect with Petra Hanga:
    LinkedIn: https://www.linkedin.com/in/petrahanga/
    Twitter: @PetraHanga
    Next Step:
    Enhance your bioprocess development strategy! Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

    • 14 min
    44: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 2

    44: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 2

    Does uncovering the secrets of glycan engineering feel like navigating a maze of molecular complexity?
    In this captivating continuation of our exploration into the world of glycan engineering, we delve deeper into groundbreaking innovations and the crucial role of analytics in ensuring consistent quality.
    Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), shares the fascinating story behind a groundbreaking technology designed to modulate antibody-dependent cell-mediated cytotoxicity (ADCC).
    You’ll get:
    Learn how advancements in high-throughput techniques are streamlining analytics for quicker insights and data-driven optimizations.Explore the future of glycan engineering, which may lead to more effective therapeutics.Understand why glycans matter across various fields of biotechnology, including monoclonal antibodies and vaccines, and discover their pivotal role in shaping the future of healthcare.Connect with Henning von Horsten:
    LinkedIn: https://www.linkedin.com/in/henning-von-horsten-b259102/Website: https://lsm.htw-berlin.de/team/prof-dr-rer-nat-hans-henning-von-horsten/Next Step:
    Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com/assessment

    • 18 min
    43: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 1

    43: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 1

    Does unlocking the secrets of glycan engineering seem like navigating a labyrinth of molecular complexity?
    In this episode, we delve into the pivotal role of glycans as critical quality attributes (CQAs) in biotherapeutics.
    Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), sheds light on the art and science of glycan engineering and analysis.
    Key highlights:
    Discover various methods scientists are utilizing to improve glycan profiles.Get insights into the challenges and solutions of off-target effects and cellular metabolic adjustments.Learn about the exciting advancements in synthesizing ideal glycans outside living cells.Connect with Henning von Horsten:
    LinkedIn: https://www.linkedin.com/in/henning-von-horsten-b259102/Website: https://lsm.htw-berlin.de/team/prof-dr-rer-nat-hans-henning-von-horsten/Next Step:
    Elevate your bioprocess development strategy — Schedule your free assessment now: https://bruehlmann-consulting.com/assessment

    • 22 min

Customer Reviews

5.0 out of 5
7 Ratings

7 Ratings

Stem Cell Guy ,

Deeply Refreshing Perspective

I am really a fan of David’s content and his approach to intriguing subjects.

MatthiasV1976 ,

Fantastic content!

Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.

genome man ,

Great content!

This podcast has gotten off to a great start, with two stellar guests to kick off the program. David does a great job in exploring topics with his guests which the bioprocessing community - and the larger biotech community - will find indispensable. His experience and knowledge in the field, and his thoughtful questions, help to establish a good rhythm quickly, and the relatively short program makes it very easy to listen to. This is a must listen show for the Smart Biotech Scientist!

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