Tumor Immunology Round Table pedro

In this edition, I discuss the recent paper of Kool et al submitted to JEM, and where the authors evaluate the effect of aluminum adjuvant in antigen response.

The authors found thad adjuvant mix results in the mobilization of phagocytes and monocytes to the peritoneal cavity upon i.p. injection of antigen, boosting antigen specific T cell response in the draining lymph nodes

The most important observation found by authors was that inflammatory monocytes mobilized by adjuvant differentiate into matured dendritic cells and such cells are key elements in the antigen T cell response.

A great reading...

For reference please check the mouse lymph node localizations on this link.

See you soon and have a nice listening

In this edition, I describe the manuscript published by the group of Cassian Yee to the New England Journal of Medicine entitled "Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1", that can be found in the volume 358 page 2698, of 2008 year series.

In this podcast I will describe a recent manuscript submitted by Liu et al to journal of Immunology 2008; 108:6044 , where {gamma}{delta} T cell knock-out mice were evaluated under situation of expontaneous prostate cancer (crossed with TRAMP mice) and in addition {gamma}{delta} T cells were also used in adoptive therapy settings against established tumors and metastatic disease.

The authors show that under the experimental design setting that {gamma}{delta} T cells play a certain role in controlling tumor growth, by reducing the tumor burden and aggressiveness.

See you next time

Hi folks,
Today I will do a short overview of a major manuscript published recently in journal immunity that presents data concerning the evaluation of NKG2D knock-out mice in the context of expontaneous tumor development.

The format of the podcast has changed to fit in my time constrains. Let me know what do you think.

See you soon, and thanks for listening

Hello

In this edition of the podcast I will discuss a paper published by
Demotte and collaborators published this year in the journal Immunity
"Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes" vol 28, pag 414 of April 2008.

In this paper the authors show that LacNAC can compete for galectin-3 binding freeing TCR from TIL to colocalize with CD8 and allow the recovery of efector functional on ex vivo freshly isolated TIL from ovarian cancer and gastric cancer.

See you next time.

 Hello

In this edition of the podcast I will discuss a paper published by
Stemberger and collaborators in the journal Immunity called "A
single naive CD8+ T cells precursor can develop into diverse effector
and memory subset" vol 27, pag 987 of December 2007.

In this very interesting paper the authors redraw the concepts of
memory T cells differentiation from naive T cells, developping a
successfull model of transfer of an single naive T cell precursor. The
paper shows that this single antigen specific naive T cell precursor
can give rise to an diversified memory T cell responses including all
subsets (central memory (CD62L positive, CD127 posit) and effector
memory (CD62L negative, CD127 positive) T cells) upon antigen challenge.

Importantly the kind of memory responses were equivalent in frequency
to the ones generated by the host mice (containing a normal size naive
pool of antigen specific T cells) against an antigenic protein.

See you next time.

PS: The audio has "clicks" artifacts that I don't know the origin. I
apologize for that.