112 episodes

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

How do you take a drone delivery service you’ve built in Rwanda and make it work in North Carolina? How do you convince people to buy a house on the Internet? How do you sell thousands of dog ramps to weiner dogs all across America when a pandemic breaks the global supply chain? 

Hosted by former Planet Money host Jacob Goldstein, What’s Your Problem helps listeners understand the problems really smart people are trying to solve right now.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

What's Your Problem‪?‬ Pushkin

    • Business
    • 4.5 • 214 Ratings

Listen on Apple Podcasts
Requires subscription and macOS 11.4 or higher

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

How do you take a drone delivery service you’ve built in Rwanda and make it work in North Carolina? How do you convince people to buy a house on the Internet? How do you sell thousands of dog ramps to weiner dogs all across America when a pandemic breaks the global supply chain? 

Hosted by former Planet Money host Jacob Goldstein, What’s Your Problem helps listeners understand the problems really smart people are trying to solve right now.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Listen on Apple Podcasts
Requires subscription and macOS 11.4 or higher

    How to Start 40 Companies (and Counting)

    How to Start 40 Companies (and Counting)

    Robert Langer has co-founded dozens of companies, holds over a thousand patents, and is a pioneering figure in drug delivery and tissue engineering. Robert has solved a lot of problems, and is working on many more with his lab at MIT. But there is one big problem that has stuck with Robert his whole career: How do you get discoveries out of the lab and into the world?
    See omnystudio.com/listener for privacy information.

    • 28 min
    Pushkin+ Early Listen: Fighting Cancer with CRISPR

    Pushkin+ Early Listen: Fighting Cancer with CRISPR

    You can hear this episode for free starting Thursday, May 23rd. To learn more about Pushkin+ offerings, like ad-free episodes, exclusive content, and early access, visit pushkin.fm or the show page on Apple.

    Last year, the FDA approved a treatment for sickle cell disease using a revolutionary new gene editing technology called CRISPR. Rachel Haurwitz conducted pioneering research on CRISPR as a graduate student. Now she’s the co-founder and CEO of Caribou Biosciences. Rachel's problem is this: How can you improve CRISPR and use it to engineer human immune cells to fight cancer? 

    The Cutting Edge of Energy Storage: Rust

    The Cutting Edge of Energy Storage: Rust

    Mateo Jaramillo is the co-founder and CEO of Form Energy. Mateo’s problem is this: How do you build batteries that can provide affordable backup power to the grid for days at a time? As it turns out, the basic technology was developed – and then mostly ignored – over 50 years ago.
    See omnystudio.com/listener for privacy information.

    • 36 min
    The First Pig to Human Kidney Transplant

    The First Pig to Human Kidney Transplant

    This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is the CEO of eGenesis, the company that raised the pig whose kidney was used for the procedure. Mike's problem is this: How do you genetically engineer pigs to provide organs – kidneys, hearts, livers – for people?
    See omnystudio.com/listener for privacy information.

    • 36 min
    Designing a Drone That Delivers

    Designing a Drone That Delivers

    Imagine picking up your phone and ordering something from Walmart. Fifteen minutes later, a drone hovers over your yard, lowers your order down to you, and zips away. Adam Woodworth wants this to be so boring you don't even notice. He’s the CEO of Wing, a drone delivery company. His problem is this: How do you turn a flashy idea like a delivery drone into something as ubiquitous as a shopping cart?
    See omnystudio.com/listener for privacy information.

    • 37 min
    How Do Psychedelics Work?

    How Do Psychedelics Work?

    Psychedelics are going mainstream. The FDA has approved ketamine for certain patients with depression, and may soon approve MDMA for post-traumatic stress disorder (PTSD). But a fundamental question remains unclear: How do psychedelics work?

    Gul Dolen is a professor of psychology and neuroscience at UC Berkeley. In a series of experiments, Gul has found evidence of a common mechanism that a wide range of psychedelics use to affect the brain. If Gul is correct, these drugs may be useful not only for people suffering from mental illness, but also for people dealing with neurological problems like strokes.
    See omnystudio.com/listener for privacy information.

    • 32 min

Customer Reviews

4.5 out of 5
214 Ratings

214 Ratings

kaerf81 ,

Love it!

One of my favorite podcasts!

Bruce JM ,

Very fun podcast

this podcast started slowly, but it has turned into one of my faves!

etherdog ,

Spurious associations don’t make a logical chain

Get a lot of data, like Skynet . That worked out well, didn’t it?

Jacob gets so many things wrong (SBF, for instance, but to his credit he admitted it and did a good self-analysis). Unhedged is just awful, and anyone promoting it probably doesn’t have a good grasp on reality. Unfortunately, the whole Pushkin brand is dissonant and tarnishes the reputation of Alexander Pushkin. The question is whether Pushkin should survive or die. It should and must die. I cannot believe how simplistic Jacob’s questions are and how racist his characterization of the employment rate is.

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