The Synthesis of Wellness Chloe Porter

We are honored to be joined by Brendan Gaughran. Brendan Gaughran, the founder of Liver Medic, holds a degree in Molecular Biology from the University of Connecticut and an MBA from Bentley University. He is an expert in gut health, liver health, the endocrine system, adrenal fatigue, and optimal diets. Brendan frequently conducts health lectures for both physicians and the general public. Through Liver Medic, he manufactures proprietary liver and digestive supplements, leveraging his extensive research and knowledge.



Topics:


Introduction


Brendan's motivation for focusing on liver and gut health


Fatty Liver and Increased Intestinal Permeability


How leaky gut and fatty liver are related
Development of fatty liver
Development of leaky gut
How the body processes toxins
The role of chronic inflammation in metabolic dysfunction
Insulin resistance


Diet and Nutrition


Diet modification strategies
Organic vs. non-organic food
GMO food
The impact of glyphosate on the gut lining and liver
Seed oils
Sugar


Specific Conditions


Alcoholic vs. non-alcoholic fatty liver disease


Nutrients and Supplements


Essential nutrients for detoxification
Supporting the body through phases 1 and 2 of liver detoxification
The benefits of NAC and milk thistle in combination


Practical Approach


Step-by-step addressing the triad of fatty liver, metabolic dysfunction, and leaky gut
Recommended duration and supplements to start with
Human optimization protocols typically include regular liver detoxification support




Check out Liver Medic's website

Use code Chloe20 to save 20% on "Leaky Gut Repair" Supplement

Brendan's YouTube Channel

https://x.com/livermedic






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In today's episode, we explore the connection between biotoxin illness (including Lyme disease) and dysautonomia, as well as nervous system dysfunction, in general. And, we outline strategies for supporting nervous system repair through addressing the root cause and using strategic phospholipid support.



Topics:

1. Introduction to the Nervous System

- Overview

- Central Nervous System (CNS): Brain and Spinal Cord

- Peripheral Nervous System (PNS): Connection to CNS, Transmission of Sensory Information and Motor Commands, Involuntary Functions



2. Divisions of the Peripheral Nervous System (PNS)

- Somatic Nervous System (SNS): Voluntary Control, Sensory (Afferent) Neurons (Function and Examples), Motor (Efferent) Neurons (Function and Examples)

- Autonomic Nervous System (ANS): Involuntary Physiological Functions, Maintenance of Homeostasis



3. Subdivisions of the Autonomic Nervous System (ANS)

- Sympathetic Nervous System (SNS): 'Fight or Flight' Response

- Parasympathetic Nervous System (PNS): 'Rest and Digest' Response

- Enteric Nervous System (ENS): Regulation of Gastrointestinal (GI) Tract



4. Dysfunction of the Autonomic Nervous System: Dysautonomia

- Definition and Symptoms

- POTS

- Some Causes: Infections (e.g., Lyme Disease), Biotoxin Illness, Other Contributing Factors



5. Mechanisms of Nerve Damage in Lyme Disease

- Direct Bacterial Invasion

- Inflammation and Cytokine Storm

- Out of Control Autoimmune Reactions



6. Impact of Lyme Disease on the Nervous System

- Cardiac Vagal Tone Impairment

- Dendritic Pruning

- Demyelination

- Small-Fiber Neuropathy: Symptoms, Improvement with Antimicrobial Treatments



7. Supporting Nervous System Repair

- Phospholipid Support: Phosphatidylcholines and Cell Membrane Integrity, Repairing Myelin Sheath, Recovery and Regrowth of Dendritic Structures

- Benefits for CNS and PNS

- Importance of Addressing Root Cause (Infection) and Repair Strategies






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In this episode, we delve into the science behind peptide bioregulators, specifically focusing on Glandokort, a natural extract from the adrenal gland. We explore the unique characteristics and mechanisms of peptide bioregulators, highlighting their tissue-specific effects and role in gene regulation. Additionally, we provide an overview of the adrenal glands' anatomy and functions, and discuss how Glandokort may aid in normalizing adrenal gland protein synthesis in the context of some types of adrenal insufficiency.



Understanding Peptides


Definition of peptides: Short chains of amino acids
Comparison of peptide bioregulators and other peptides (e.g., BPC-157)
Size and function of peptide bioregulators
Bioregulators penetrate the cell membrane AND the nuclear membrane


Function of Peptide Bioregulators


Role in restoring organ balance
Tissue-specific effect


Gene Regulation and Cellular Differentiation


Importance of gene regulation
Nuance of cell differentiation and gene expression
Today's focus: gene regulation impacting a cell's functional activity


Mechanism of Bioregulators


Interaction with DNA and gene expression
Binding to histone proteins
Promotion of gene expression in tissue-specific cells


History and Development of Peptide Bioregulators


Early isolation from animal tissues
Examples of tissues used for extraction
Development of the synthetic peptide bioregulators


Natural vs. Synthetic Peptide Bioregulators


Availability of natural and synthetic supplements
Focusing on the natural extract of the adrenal gland: Glandokort


Adrenal Glands Overview


Location and function of adrenal glands
Division into cortex and medulla

7.1 Adrenal Cortex


Zona Glomerulosa: Production of mineralocorticoids (aldosterone)
Zona Fasciculata: Production of glucocorticoids (cortisol)
Zona Reticularis: Production of androgens

7.2 Adrenal Medulla


Production of catecholamines (adrenaline and noradrenaline)
Role in 'fight or flight' response


Glandokort Supplement


Description: Natural adrenal gland peptides
Function: Normalizing adrenal gland protein synthesis
Context of HPA-axis dysfunction or "adrenal fatigue"
Importance of working with a licensed medical professional
More research is needed






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In today's episode, we explore the role of Thymosin Alpha 1 Peptide in modulating the immune system, specifically its effects on Th1 and Th2 responses. The episode further delves into the mechanisms by which Borrelia burgdorferi evades immune detection and offers strategies to enhance immune effectiveness against this stealthy pathogen. Additionally, we discuss the broader implications of immune modulation in chronic Lyme disease and mold exposures.


Topics:


Introduction


Recap of the series on Lyme and mold
Highlighting the key steps in the biotoxin illness resolution process
Importance of working with a medical professional


Key Steps in Biotoxin Illness Resolution


Lowering inflammation
Lipid replacement therapy (phospholipids)
Use of antimicrobial and antiparasitic herbs for Lyme and coinfections
Employing binders to eliminate toxins and reduce inflammation
Checking for MARCoNS and utilizing treatments like silver spray or biofilm busters (e.g., xylitol)
Detoxification post-MARCoNS clearance using agents like chlorella and glutathione
Assessing and normalizing various health markers (e.g., ADH, osmolality, MMP9, C4a, C3a, TGF-beta, sex hormones)


Additional Resources and Episodes


Early stages of Lyme infection and Herxheimer reaction: Episode 116
Chronic inflammation and biotoxin management: Episode 117
Role of binders in interrupting enterohepatic circulation and toxin elimination


Discussion on Biofilm


Importance of addressing biofilm in antimicrobial therapies
Potential supplements and strategies (e.g., garlic, oil of oregano, stevia)


Overview of Lyme Disease Impact & Immune Function


Chronic inflammation due to miscommunication between the innate and adaptive immune systems + dysregulated adaptive responses
How borrelia evades the immune responses


Immunomodulation in Lyme Disease


Background on immune modulation
Role of T cells in adaptive immune response
Th1 and Th2 cell imbalance in chronic Lyme
Strategies to support Th1 cells and decrease Th2 response


Focus on Thymosin Alpha 1


Benefits of Thymosin Alpha 1 in modulating immune function
Promoting Th1 response and managing Th2 dominance
Effects on regulatory T cells (Tregs) and immune tolerance


Conclusion


Reminder to work with a Lyme literate or biotoxin illness literate medical professional






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In this episode, we undertake a detailed examination of the diverse mechanisms of action underlying various binders employed in detoxification protocols, with a particular focus on their application in biotoxin illnesses such as Lyme disease. We dissect the differential efficacy of bile acid sequestrants like cholestyramine versus natural binders such as activated charcoal and zeolite, elucidating their distinct modes of action in toxin adsorption and excretion pathways. Moreover, we elucidate the intricate interplay between chemical charges of binders and biotoxins like lipopolysaccharides (LPS), shedding light on the complexities of binder selection for optimal detoxification outcomes.



Topics:

1. Introduction to Binders

- Definition of binders

- Purpose in detoxification

- Application in Lyme disease treatment



2. Mechanisms of Action

- Bile Acid Sequestrants vs. Natural Binders

- Bile Acid Sequestrants:

- Function of cholestyramine

- Interaction with bile acids

- Impact on toxin excretion

- Natural Binders:

- Adsorption mechanism

- Broad-spectrum binding capacity



3. Chemical Charge Considerations

- Impact of charge on binding efficacy

- Interaction with biotoxins like lipopolysaccharides (LPS) which are negatively charged

- Paper published showing how activated charcoal (-) can help bind LPS (-), indicating that charge doesn't totally eliminate its binding ability



4. Selection of Binders

- Bile Acid Sequestrants:

- Cholestyramine

- Okra powder (Beets, Carrots...)

- Natural Binders:

- Activated Charcoal

- Bentonite Clay

- Zeolite

- Chlorella

- Cilantro

- Pectin

- Importance of using a spectrum of binders



5. Timing and Compatibility

- Considerations for simultaneous use of different binders

- Importance of timing in binder intake



6. Supporting Detoxification Process

- Promotion of bile flow: ox bile + bitters

- Support for liver detoxification

- Supplements for liver support



7. Conclusion and Recap

- Summary of binder types and their roles

- Importance of binders in biotoxin illness treatment

- Recognition of compromised immune system's role in toxin clearance (HLA genes)






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Today I am addressing the "early steps" in combatting Lyme or mold. So, I begin by diving into the phenomenon of Herxheimer reactions, elucidating its occurrence following antimicrobial therapy initiation for Lyme disease. Through this, I explore the intricate interplay between microbial factors, such as the release of endotoxins (LPS), and host immune responses, leading to a cascade of inflammatory reactions. Moreover, I provide practical strategies that may help mitigate Herxheimer reactions, including gradual dose titration, anti-inflammatory supplementation, binders, baths, and support for the body's natural detoxification pathways (liver, lymph, kidneys, and more).



Topics:

1. Understanding Herx Reactions

- Definition and Manifestation

- General Overview of Symptoms



2. Underlying Mechanisms of Herx Reactions

- Host Immune Responses

- Microbial Factors



3. Microbial Factors in Herx Reactions

- Release of Endotoxins

- Role of Gram-Negative Bacteria

- Impact on Immune Response (LPS)

- Example: Lyme Disease as a Model



4. Inflammatory Response

- Pro-inflammatory Cytokines

- TNF-α, IL-6, IL-1β

- Immune Response Propagation

- Vasodilation

- Vascular Permeability

- Immune Cell Recruitment



5. Acute-Phase Response

- Ex: Induction of Fever via the Hypothalamus

- Systemic Manifestations and Other Symptoms



6. Phagocytic Immune Cells

- Macrophages

- Antigen Presentation

- Cytokine Release

- Neutrophils

- Role in Early Innate Immune Response



7. Transition to Adaptive Immune Response

- Specificity

- Role of T Cells and B Cells

- Immunological Memory



8. Implications of Inefficient Adaptive Immune Response Activation

- Chronic Infection and Inflammation

- Cause: Disruption in Antigen Presentation



9. Biotoxin Illness and Genetic Factors

- Role of HLA Genes

- Chronic Inflammatory Response Syndrome



10. Mitigating Herx Reactions

- Slow Titration of Antimicrobial Therapy

- Reducing Inflammation: Omega-3s, SPMs, Curcumin, Quercetin, Ginger, Boswellia, etc.

- Supporting Clearance Pathways

- Liver, Lymph, Kidneys

- Hydration and Proper Elimination

- Epsom Salt Baths

- Use of Binders: Activated Charcoal, Chlorella, Cholestyramine etc.






Thank you to our episode sponsor:

⁠Check out The Honest Tooth Here!⁠





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