Medizin - Open Access LMU - Teil 09/22

Ludwig-Maximilians-Universität München
  • 0.0 (0)
  • EDUCATION
Medizin - Open Access LMU - Teil 09/22 Podcast

Die Universitätsbibliothek (UB) verfügt über ein umfangreiches Archiv an elektronischen Medien, das von Volltextsammlungen über Zeitungsarchive, Wörterbücher und Enzyklopädien bis hin zu ausführlichen Bibliographien und mehr als 1000 Datenbanken reicht. Auf iTunes U stellt die UB unter anderem eine Auswahl an elektronischen Publikationen der Wissenschaftlerinnen und Wissenschaftler an der LMU bereit. (Dies ist der 9. von 22 Teilen der Sammlung 'Medizin - Open Access LMU'.)

  1. 01/01/1993

    Advantages of the new loop diuretic torasemide over furosemide in patients with cirrhosis and ascites

    Torasemide is a new loop diuretic with a longer half-life and longer action than furosemide in healthy subjects. In order to evaluate the pharmacodynamic effects, single oral doses of furosemide (80 mg) and torasemide (20 mg), which were equipotent in healthy subjects, were given to 14 patients with cirrhosis and ascites. Before the study patients underwent an equilibration period of 4 days without diuretics. The drugs were alternated following a randomized double-blind cross-over design after a wash-out period of at least 2 days. Urine was collected at defined intervals for 24 h after drug administration and blood samples were taken before, 6 h and 24 h after medication. Torasemide induced greater cumulative 24 h diuresis (2863 ± 343 vs. 2111 ± 184 ml, p 0.01) than furosemide. Torasemide did not differ from furosemide for cumulative 0–6 h sodium excretion (96 ± 17 vs. 92 ± 23 mmol sodium) but caused a more pronounced cumulative 6–24 h natriuresis (38 ± 11 vs. 17 ± 4 mmol, p 0.05). Five patients exhibited a weak response to furosemide (0–36 mmol sodium/24 h, median 24 mmol; 690–1460 ml urinary volume/24 h, median 1325 ml). These patients showed significantly higher natriuresis and diuresis following torasemide (26–136 mmol sodium/24 h, median 78 mmol, p 0.05; 1670–3610 ml urinary volume/24 h, median 2200 ml, p 0.05). Twenty-four hours after administration of both drugs there were no significant changes in hemodynamic, renal or hormonal parameters. No adverse effects were noted with either treatment. These findings suggest that torasemide might be more advantageous than furosemide in the treatment of ascites due to cirrhosis.

  2. 01/01/1993

    Azygos and hepatic extraction of atrial natriuretic factor (ANF) in patients with cirrhosis

    Medizin - Open Access LMU - Teil 09/22

  3. 01/01/1993

    Central blood volume in cirrhosis

    Medizin - Open Access LMU - Teil 09/22

  4. 01/01/1993

    Detection of C-Type natriuretic peptide compared with brain and atrial natriuretic peptide transcripts in human heart by the polymerase chain reaction

    Medizin - Open Access LMU - Teil 09/22

  5. 01/01/1993

    Detection of C-type natriuretic peptide (CNP) transcript in the rat heart and immune organs

    Previous studies suggested the expression of mRNA, coding for CNP, exclusively in the central nervous system. In the present study, using the polymerase chain reaction (PCR) technique instead of the less sensitive Northern blot hybridization, CNP-specific sequences have also been detected in rat atria and ventricles of the heart as well as in organs of the immune system (thymus, spleen and lymph nodes). Parallel PCR-assays documented ANP-mRNA in these tissues. To verify specificity of the PCR-products, Southern blots have been hybridized with a third internal oligonucleotide and amplification products have been sequenced. The relative level of CNP-mRNA in these tissues was estimated to be in the range of 1-9% of total brain CNP transcripts. The results suggest that the peptide may have a peripheral as well as a central site of action. In light of its pronounced effect on cell proliferation, particular interest should focus on a possible role of CNP in the immune system.

  6. 01/01/1993

    Differentialdiagnose und pathophysiologische Grundlagen des Ascites

    Medizin - Open Access LMU - Teil 09/22

  7. 01/01/1993

    Differentiation of endothelin-1 and endothelin-3 concentrations

    Inhaltsverzeichnis fehlt.

  8. 01/01/1993

    Disposal of atrial natriuretic factor (ANF99-126) in patients with cirrhosis

    Medizin - Open Access LMU - Teil 09/22

See All (250)

About

Die Universitätsbibliothek (UB) verfügt über ein umfangreiches Archiv an elektronischen Medien, das von Volltextsammlungen über Zeitungsarchive, Wörterbücher und Enzyklopädien bis hin zu ausführlichen Bibliographien und mehr als 1000 Datenbanken reicht. Auf iTunes U stellt die UB unter anderem eine Auswahl an elektronischen Publikationen der Wissenschaftlerinnen und Wissenschaftler an der LMU bereit. (Dies ist der 9. von 22 Teilen der Sammlung 'Medizin - Open Access LMU'.)

Information

More From Ludwig-Maximilians-Universität München

To listen to explicit episodes, sign in.

Stay up to date with this show

Sign in or sign up to follow shows, save episodes and get the latest updates.
Select a country or region

Africa, Middle East, and India

Asia Pacific

Europe

Latin America and the Caribbean

The United States and Canada