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Dr. Gur-Cohen is an Assistant Professor of Medicine in the Division of Regenerative Medicine at the University of California, San Diego. Dr. Gur-Cohen’s work has unearthed the lymphatic capillary network as a novel stem cell niche component, and her multidisciplinary strategy has advanced our knowledge of how stem cells synchronize and coordinate tissue regeneration.

In this conversation, Shiri and Kellen talk about stem cells, lymphatics, and microscopy. As a relatively new principal investigator, Shiri has a lot of advice for trainees in regards to choosing a postdoc, and she talks with Kellen about the topic at length in this conversation.

Gur-Cohen lab website: https://gurcohenlab.com/

Lymphatics stem cell interaction paper: https://pubmed.ncbi.nlm.nih.gov/31672914/

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In this episode, Kellen speaks with Dr. Mitchell Kronenberg. Mitch is the chief scientific officer of the La Jolla Institute for Immunology, an adjunct professor at UC San Diego, and the co-director of a collaborative effort between the La Jolla Institute and UC San Diego called the Program in Immunology. Mitch and Kellen talk about unconventional T cells, autoimmunity, barrier immunity, chimeric antigen receptor (CAR) T cells, and the future of immunology. They also discuss Mitch’s philosophies related to science, mentorship, and life.

Recent Kronenberg lab paper with intravital microscopy: https://pubmed.ncbi.nlm.nih.gov/35905286/

Kronenberg lab website: https://www.lji.org/labs/kronenberg/

Mitch’s Wikipedia page: https://en.wikipedia.org/wiki/Mitchell_Kronenberg

Correction: When Kellen mentioned the published CAR T trial in human autoimmunity, he misspoke and said multiple sclerosis (MS) but the trial he was referring to was in patients with lupus. That said, published preclinical data suggests CAR T therapy may also work in MS patients.

CAR T cell therapy in patients with lupus: https://pubmed.ncbi.nlm.nih.gov/36109639/

CAR T cell therapy in MS mouse model: https://pubmed.ncbi.nlm.nih.gov/36206355/

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To help us spread science, please consider writing a review, sharing this episode with your friends and colleagues, or donating to support our work (Venmo @Kellen-Cavagnero).

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In this episode, Kellen speaks with Dr. Amir Zarrinpar. Amir is a board-certified gastroenterologist and an assistant professor at UC San Diego in the department of medicine. He completed his undergrad at Harvard, M.D. and Ph.D. at UCSD, and postdoc at the Salk Institute in Satchin Panda’s lab. In this conversation, Amir and Kellen talk about diabetes and obesity, time-restricted feeding, and engineered native bacteria—highlighting the Zarrinpar lab’s recent paper published in the journal Cell. Kellen and Amir also dig into Amir’s philosophies related to science, mentorship, and life.

Live bacterial therapeutics paper: https://pubmed.ncbi.nlm.nih.gov/35931082/

Zarrinpar Lab website: https://zarrinparlab.org/

Thank you to our sponsors, NCI & CCMI!

To help us spread science, please consider writing a review, sharing this episode with your friends and colleagues, or donating to support our work (Venmo @Kellen-Cavagnero).

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In this episode, Kellen speaks with Dr. David Gonzalez. David is an associate professor at UC San Diego in the pharmacology department of the school of medicine and the Skaggs school of pharmacy. He’s also the founder and director of the UCSD collaborative center for multiplexed proteomics. The Gonzalez lab researches host-microbe interactions and specializes in proteomics approaches. Kellen and David talk about David’s inspirational journey to becoming a principal investigator. They also discuss proteomics, mentorship, and two of the Gonzalez lab’s recent publications related to inflammatory bowel disease (linked below).

IBD proteomics papers: https://pubmed.ncbi.nlm.nih.gov/35999575/ https://pubmed.ncbi.nlm.nih.gov/35087228/

Gonzalez lab website: https://www.gonzalezlab.org/

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In this episode, Kellen interviews Dr. Victor Nizet, a distinguished professor of pediatrics and pharmaceutical sciences at UCSD and the vice chair of basic research in the department of pediatrics at UCSD. Kellen and Victor discuss one of the Nizet lab’s recent publications (led by Josh Sun, Pharm.D. Ph.D.) identifying novel treatment strategies for Staph aureus-induced sepsis. Kellen and Victor also talk about Victor’s career path and scientific philosophies.

S. aureus-induced sepsis paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121309/

Nizet lab website: http://nizetlab.ucsd.edu/

Victor’s Twitter handle: @victornizet

Thank you to our sponsors, NCI & CCMI!

To help us spread science, please consider writing a review, sharing this episode with your friends and colleagues, or donating to support our work (Venmo @Kellen-Cavagnero).

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In this episode, Kellen sits down for a conversation with Richard Daneman, an associate professor of neurosciences and pharmacology at UCSD. Kellen and Rich discuss the Daneman lab’s recent paper identifying a novel role of fibroblasts in the central nervous system as well as Rich’s philosophies about science and mentorship.

CNS fibroblast paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877789/

Daneman website: https://www.danemanlab.com/

Thank you to our sponsors, NCI & CCMI!

To help us spread science, please consider writing a review, sharing this episode with your friends and colleagues, or donating to support our work (Venmo @Kellen-Cavagnero).

Please reach out to us via email (kcavagnero@gmail.com) or Twitter (@KellenCavagnero) with any questions, comments, topic suggestions, etc.