Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant

Myeloma beware, it's time to bring out the big guns. We are incredibly thankful to be joined by a peak predator of plasma cells, Dr. Christian Bryant. He is a consultant Haematologist at RPA in Sydney, has a PhD on the immunology of myeloma and is driven by a passion to improve the treatment and understanding of all things myeloma.

TIMESTAMPS
2:18 - Intro to Christian Bryant
3:05 - Why Haematology?
5:31 - Why (oh god why) myeloma?
7:28 - Heavy metal, heavy chains
9:28 - Chromothripsis - The Cause That Breaks The Camel's Back?
13:45 - In praise of plasma cells
18:38 - Genomics to risk-stratify precursor states - should we bother?
20:32 - Predicting response and high risk disease
21:43 - IMS Criteria - High Genomic Risk
28:22 - Response Kinetics - When are you nervous?
31:31 - Balancing maintenance Len vs. secondary malignancies
39:34 - Other agents for maintenance?
44:44 - CAR-T - A New Hope?
49:10 - T cell exhaustion
50:21 - What are the CAR-T target molecules for MM?
53:27 - Any hope for a cure?
57:35 - MRD Matters

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au