The Proof with Simon Hill Live better for longer

Episode #323. Oreo cookies or statins – which is more effective in reducing LDL cholesterol? The results from one study might surprise you. Join me as I sit down with Oxford PhD graduate and Harvard Medical student Dr Nick Norwitz to discuss the lipid energy model, what it has to do with Oreos, and how different diets affect your health.
You’ll learn about Dr Norwtiz’s health journey, including his experience with inflammatory bowel disease and the ketogenic diet. We discuss cholesterol management and cardiovascular disease risk, lean mass hyper-responders, and statins. This episode is an important and informative reflection on scientific curiosity and misinformation.

Specifically, we discuss:

Introduction (00:00:00)

The Importance of Curiosity in Scientific Progress (04:39)

Exploring the Oreo vs. Statin Experiment on Lean Mass Hyper Responders (08:52)

Scientific and Clinical Impact of the Oreo Study (25:03)

Addressing Criticisms and Misinterpretations of the Study (34:47)

Navigating Statin Discussions on Social Media (40:27)

Debunking Claims About PCSK9 Inhibitors (53:18)

Challenging Misinformation in Health Communities (59:15)

The Lipid Energy Model and Lean Mass Hyper Responders Explained (01:06:59)

Defining Lean Mass Hyper Responders: Key Terminology (01:14:19)

Practical Advice for Lean Mass Hyper Responders (01:30:35)

The Carnivore Kid: An Intriguing Case Study (01:41:48)

Personal Struggles with Ulcerative Colitis and Starting Keto (01:45:24)

Balancing Medication and Personal Health Choices (01:50:31)

Debating Dietary Interventions for Inflammatory Bowel Disease (02:11:09)

Challenges in Dietary Research and Medical Interventions (02:25:55)

Introducing the Lipid Energy Model and Its Mechanisms (02:34:49)

Debating the Validity of the Lipid Energy Model (02:44:29)

Long-Term Effects of Ketosis and Carb Restriction (02:52:31)

Critiques and Limitations of the Lipid Energy Model (02:57:17)

ApoB-Containing Lipoproteins and Atherosclerosis (03:03:50)

Current Research and Future Directions on LMHR (03:06:41)

Exploring Inflammatory Responses to Fibre (03:16:12)

The Link Between Saturated Fats and Heart Disease (03:20:49)

Closing Thoughts on Effective Scientific Communication (03:25:29)

The Lean Mass Hyper Responders Debate: Addressing Frustrations (03:32:32)

Understanding Carbohydrate Reintroduction Physiology (03:46:58)

Diet-Specific Strategies to Lower ApoB (03:55:16)

Examining Claims About ApoB and Cardiovascular Disease (04:01:50)

Trade-offs in Lowering ApoB Levels (04:12:54)

Exploring the Link Between All-Cause Mortality and ApoB (04:22:42)

Lean Mass Hyper Responders and ApoB: A Unique Profile (04:44:54)

Concluding Thoughts and Future Discussion Topics (04:48:10)


Connect with Nick Norwitz, PhD on Twitter/X, Instagram, and YouTube. Make sure to check out the full show notes for additional resources and supporting studies.

This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
LMNT
Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon.

Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill

Episode #322. Did you know that 30% of cancers are related to obesity? Join me as I sit down with Harvard Professor and endocrinologist Dr Christos Mantzoroz to discuss fatty liver disease, metabolic health, and hormones.
You’ll learn about why so many people are obese and whether you can be overweight and healthy. Dr Mantzoroz breaks down budget-friendly ways to evaluate your metabolic health, explains how hormones affect your weight, and offers his insight on how to treat obesity. Overall, this episode is a masterclass in metabolic health and fatty liver disease.

Specifically, we discuss:

Introduction to The Latest Obesity Research Findings (00:00)

The Evolving Understanding of Obesity Science (03:49)

Uncovering New Fat Storage Mechanisms (10:57)

Modern Techniques for Accurate Body Fat Measurement (15:02)

Why Maintaining Weight Loss Is So Challenging (20:01)

Evolutionary Insights into Human Fat Storage (25:12)

How Leptin Regulates Energy Balance and Health (29:17)

New Approaches to Break Through Weight Set Points (39:27)

Environment's Role in Weight Gain Beyond Diet (45:49)

Decoding the Genetics of Fat Storage and Metabolism (52:59)

Non-Alcoholic Fatty Liver Disease Explained (55:40)

Evidence-Based Nutrition for Optimal Liver Health (01:05:25)

Promising Advances in Non-Invasive Liver Tests (01:10:49)

Oestrogen's Impact on Metabolism (01:20:14)

The Link Between Liver Fat and Insulin Resistance (01:22:04)

Addressing America's Growing Metabolic Health Crisis (01:26:11)

Outro (01:27:11)


Connect with Christos Mantzoros, MD DSc PhD h.c. mult. on LinkedIn, and discover his work here.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Cozy Earth
Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #321. You’ve heard me interview hundreds of nutrition experts; now it’s time for me to share my comprehensive views on nutrition, health, and longevity. Join me as I’m interviewed by André Duqum in this conversation originally recorded for the Know Thyself podcast.
This episode covers the foundations of healthy eating and my take on common nutrition controversies. You’ll learn how to decode health information you find online, why a plant-focused diet is the best way forward, and how to discover the optimal diet for you. Overall, we discuss what to eat and avoid, when to eat, and how your food choices impact your body and the planet.

Specifically, we discuss:

Understanding Nutrition Science (04:07)

The Role of Observational Studies in Nutrition (09:18)

What Is the Most Beneficial Diet for Humans? (13:12)

Simon Hill's Personal Journey and Motivation (19:38)

Five Pillars of Longevity (27:50)

Importance of Protein in the Diet (31:27)

Understanding Seed Oils and Polyunsaturated Fats (50:23)

Importance of Fibre in the Diet (58:32)

Choosing the Best Animal Proteins (01:10:06)

Role of Fake Meats in a Plant-Based Diet (01:14:52)

Metabolic Health and Dietary Fats (01:19:40)

Supplementation and Nutrient Gaps (01:24:22)

Debunking Myths About Anti-Nutrients in Plants (01:30:20)

The Soy Controversy Explained (01:38:20)

Challenges of Plant-Based Diets (01:41:29)

Environmental Impact of Diet Choices (01:59:04)

Optimising Meal Timing (02:07:07)

Importance of Relationships for Longevity (02:12:52)


Connect with André Duqum on Instagram, and discover the Know Thyself podcast on Instagram or at the official website, https://www.knowthyself.one/.

This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
LMNT
Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #320. Are you part of the 20% of people with this dangerous gene? There’s a cheap, simple test you can do just once in your life to find out. Join me as I sit down with renowned lipidologist Dr Thomas Dayspring to help you understand Lipoprotein(a) and the test that might change your life.
In this episode, you’ll learn what Lp(a) is and how it can affect your cardiovascular disease risk through two key pathways. Dr Dayspring unpacks why it’s so important to test, how to ask for this test, and what to do with your results.

Specifically, we discuss:

Introduction (00:00)

Demystifying Lipoprotein(a): An Overview of its Role in Cardiovascular Health (02:54)

Genetic Inheritance Patterns and Variability of Lipoprotein(a) (10:11)

Drug Development Strategies for Reducing Lipoprotein(a) Levels (14:50)

Exploring the Functional Role and Genetic Variations of Lipoprotein(a) (20:27)

Inside the Artery Walls: Mechanisms and Structure of Lipoprotein(a) (32:34)

A Deep Dive in Production to Measurement of Lipoprotein(a) (42:32)

Identifying High-Risk Indicators for Lipoprotein(a) (58:54)

Statins and Elevated Lipoprotein(a): Understanding the Relationship (01:11:42)

Exploring PCSK9 Inhibitors in Lipoprotein(a) Management (01:20:30)

Emerging Treatments and Future Therapies for Lowering Lipoprotein(a) (01:31:22)

Exploring Lifestyle Considerations and Alternative Therapies (01:34:42)

Oxidized Phospholipids and Their Role in Cardiovascular Health (01:43:15)

Relationship Between Oxidized Phospholipids and Lipoprotein(a) (01:52:00)

Understanding Aortic Valve Calcification and Its Link to Lipoprotein(a) (01:59:40)

Key Takeaways and Future Landscape of Lipoprotein(a) Treatments (02:06:52)

Conclusion and Final Remarks (02:13:30)


Connect with Dr Thomas Dayspring on Twitter/X. Listen to our previous lipid series and download the cheat sheet here.

This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Cozy Earth
Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #319. Join me today as I sit down with a very special guest: my dad, Professor Michael Hill, PhD. Dad’s journey as a scientist has inspired my own work and taken our family across the globe, and I’m honoured to host him as he shares his story from early career discoveries to current research.
As well as getting an inside look at Dr Hill’s academic career, you’ll learn about microvasculature (very small blood vessels), including what they are and how they impact human health. Dad also shares his experience with a heart attack, offers advice on preventing atherosclerosis, and weighs in on the Ozempic and vaping conversations.

Specifically, we discuss:

Introduction (00:00)

Childhood Memories and Early Interests (03:19)

Pursuing a Career in Biochemistry (08:36)

Microvasculature and Diabetes Research (12:12)

Early Research on Investigating Blood Properties and Diabetes (17:44)

Family Stories and Moving to the U.S. (28:47)

Returning to Australia and Continued Research (36:39)

Exploring Microvessel Behaviours: Research at RMIT (41:34)

Dealing with Health Challenges and Maintaining Work-Life Balance (46:20)

Understanding Microvascular Functions and Cardiac Health (50:32)

Exploring Vessel Constriction and Small Blockages: A Closer Look (01:00:15)

Understanding the Impact of Large Arterial Stiffness on Vascular Health (01:07:01)

Identifying Risk Factors: A Comprehensive Approach to Vascular Well-being (01:11:01)

Personal Views on the Evolution of Scientific Research Access (01:19:39)

Returning to the USA: Advancing Research on Blood Vessel Mechanisms (01:21:58)

COVID-19 and Metabolic Syndromes: Exploring the Early Research Connections (01:27:30)

Current Research and Future Directions (01:29:29)

Reflecting on a Career Dedicated to Science: Family, Achievements, and Future Directions (01:34:48)


If you’re interested in learning more about Dad’s work and career, head to his profile here.

This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.
Shopify
Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof.
Cozy Earth
Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants

Episode #318. 50,000 women. 30 years of follow-up. The results of a new study are in: learn the truth about how your protein intake will affect your long-term health. What kind of protein should you consume? How much? And what difference will it really make on longevity?
Today, I’m unpacking the results from the new study in the American Journal of Clinical Nutrition, “Dietary protein intake in midlife in relation to healthy aging - results from prospective Nurses' Health Study cohort”.
This new study from researchers at Harvard University and Tufts University has been regularly misinterpreted online, and in this episode, I’ll set the facts straight. Learn the three most important protein takeaways from this study, hear my take on Layne Norton’s interpretation, and crack the code to using protein as a tool for healthy aging.

Specifically, I cover:

Introduction to Protein and Longevity (00:00)

Study Overview and Methodology (01:24)

Key Findings on Protein Sources (05:33)

Lane Norton's Review and Critique (06:38)

Analysis of Different Protein Types (10:02)

Practical Recommendations for Protein Intake (17:13)

Conclusion and Final Thoughts (21:34)


If you’re interested in the Danish Dietary Guidelines, you can find them in English here.

This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
Momentous
My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book