197 episodes

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

The Peter Attia Drive Peter Attia, MD

    • Health & Fitness
    • 4.7 • 320 Ratings

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

    #161 - AMA #23: All Things Nicotine: deep dive into its cognitive and physical benefits, risks, and mechanisms of action

    #161 - AMA #23: All Things Nicotine: deep dive into its cognitive and physical benefits, risks, and mechanisms of action

    In this “Ask Me Anything” (AMA) episode, Peter and Bob dive deep into nicotine, a complicated and interesting molecule that has effects on both the brain and the body. They analyze the results of the studies that describe nicotine’s cognitive benefits and potential for inducing weight loss. They talk about a smoking cessation technique called nicotine replacement therapy and give a full breakdown of the various routes of administration, dosing, and safety. Finally, they explore the fascinating and counterintuitive observation that cigarette smokers are less likely to get a severe case of COVID-19.

    If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #23 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

    We discuss:


    How Peter first became interested in the potential benefits of nicotine [1:15];
    Untangling nicotine from tobacco [6:00];
    Nicotine replacement therapy (NRT) for quitting smoking: products, protocols, and a review of the literature [9:30];
    The cognitive benefits of nicotine: Overview of the literature [15:50];
    Where nicotine has the most positive impact on cognition [30:30];
    Possible mechanisms conferring the benefits of nicotine [37:00];
    How modafinil and other nootropics compare to nicotine [47:15];
    How nicotine may induce weight loss [54:00];
    Relationship between smoking and COVID-19: Analyzing the observation that smoking appears protective against COVID-19 [1:01:45];
    Breakdown of the various nicotine replacement therapies: route of administration, dosing, and safety [1:11:30];
    Concluding thoughts on nicotine: use cases, addictive properties, and more [1:19:45]; and
    More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/ama23 

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    #160 - Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants

    #160 - Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants

    Paul Offit is a pediatrician specializing in infectious diseases and an expert in virology and vaccine development. He currently serves on the FDA committee evaluating COVID-19 vaccines. In this episode, Paul’s second appearance on The Drive, he provides an update on all the SARS-CoV-2 vaccines currently deployed, explains why the concerns raised around the mRNA vaccines are not legitimate, and offers his view on the prospects and timeframe of reaching herd immunity. He also takes a deep dive into immunology, explaining the short-term and long-term immune response to both natural infection and vaccination and how these two can function together to provide durable immunity. Additionally, they discuss the theories on the origins of this virus, what impact the new COVID-19 variants might have, and the recent pausing of the J&J vaccine. Finally, they discuss how we can be better prepared for an inevitable future outbreak of a novel virus. This episode was originally recorded on April 14, 2021.
    We discuss:
    Overview and current status of the SARS-CoV-2 vaccine strategies [4:10];
    Addressing concerns about mRNA vaccines [9:00];
    How the failure to make an effective HIV vaccine aided the development of a COVID-19 vaccine [16:45];
    Where SARS-CoV-2 falls on the spectrum of its ability to mutate and what that means for immunity and vaccination [21:30];
    How the combination of short-term and long-term immune response to SARS-CoV-2 work together to provide durable immunity [28:00];
    Importance of understanding relative vs. absolute risk reduction [38:15];
    Implications of pausing the J&J vaccine due to reports of blood clotting in the brain [42:45];
    What constitutes herd immunity and the concerns of rising vaccine hesitancy [47:45];
    When we might reach herd immunity, future vaccines for children, and long-term outlook for maintaining population immunity [58:45];
    Theories about the origins of SARS-CoV-2 [1:07:00];
    Preparing for the possibility of a future pandemic and how we can learn from our mistakes [1:10:40]; and
    More.
    Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/pauloffit2 

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    #159 - Peter Hotez, M.D., Ph.D.: Evolution of the anti-vaccine movement, the causes of autism, and COVID-19 vaccine state of affairs

    #159 - Peter Hotez, M.D., Ph.D.: Evolution of the anti-vaccine movement, the causes of autism, and COVID-19 vaccine state of affairs

    Peter Hotez is an internationally recognized physician-scientist in neglected tropical diseases and vaccine development. In this episode, they first follow up on the podcast episode (#158) with Brian Deer (the investigative journalist who exposed the complex and disturbing story behind the infamous 1998 Lancet paper by Andrew Wakefield linking the MMR vaccine and autism) with a broader discussion about the origin and evolution of the anti-vaccine movement. They explore some of the specific claims being made around vaccine additives, the timing of when vaccines are given, and claims about issues with the HPV vaccine specifically. Next, Dr. Hotez shares his own journey as a parent of an autistic child and speaks of the challenges of diagnosing autism, what could account for the seeming increase in the prevalence, and whether there is any support for the notion that environmental triggers play a role. They close out with a discussion on the state of affairs with respect to COVID-19 vaccination, comparing the various vaccines as well as the challenges that emerging variants of the virus may present. This episode was originally recorded on April 2, 2021.

     

    We discuss:
    The stubborn persistence of anti-vaccine sentiment (3:00); A closer look at claims about thimerosal and vaccine spacing causing autism (12:00); The Hib vaccine: An example of the profound difference a vaccine can make (23:30); The controversy surrounding the human papillomavirus (HPV) vaccine (30:45); The growing anti-science sentiment, COVID vaccine hesitance, and the basis of the anti-vaxx movement (39:00); The origins of autism, and Hotez’s personal story as a parent of an autistic child (1:02:45); The challenge of diagnosing autism, increasing prevalence, and a potential parallel to Alzheimer’s disease (1:14:15); Comparing the various COVID-19 vaccines and the impact of emerging variants of the virus (1:30:00); Global vaccination challenges and “vaccine diplomacy” (1:40:45); and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/PeterHotez3 

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    #158 - Brian Deer: A tale of scientific fraud—exposing Andrew Wakefield and the origin of the belief that vaccines cause autism

    #158 - Brian Deer: A tale of scientific fraud—exposing Andrew Wakefield and the origin of the belief that vaccines cause autism

    Brian Deer is an award-winning investigative journalist best known for his coverage of the pharmaceutical industry. In this episode, he and Peter discuss the content of his book, The Doctor Who Fooled the World: Science, Deception, and the War on Vaccines, which exposes the complex and disturbing story behind the infamous 1998 Lancet paper by Andrew Wakefield linking the MMR vaccine and autism. Brian explains how doctors led by Wakefield, a lawyer, and an anti-vaccination parents’ group worked together on a study to validate their preconceived belief that the MMR vaccine caused autism. He reveals what happened behind the scenes as the study was carried out, explains problems in the lab, and discusses inconsistencies in the analysis.  In the end, this is a story that serves as a cautionary tale about the consequences of science driven by an agenda rather than by a spirit of open inquiry.
     
    We discuss:
    How Andrew Wakefield’s flawed approach to scientific research led to the belief that vaccines cause autism (3:25); The importance of following the scientific method, and how Wakefield twisted the science to link measles virus to Crohn’s disease (14:15); The backstory behind Andrew Wakefield’s infamous 1998 Lancet paper linking the MMR vaccine and autism (26:45); The many flaws and disturbing aspects of Wakefield’s study: suffering children and failure to do strain-specific sequencing (45:15); The epicenter of fraud: Bogus PCR testing furthering the belief that measles virus from the MMR vaccine caused autism (1:00:00); Additional issues that contaminated the study results (1:22:15); Discovering the misrepresented medical records for the kids involved in the study leading to the retraction of the Lancet paper and Wakefield losing his license (1:31:00); The resurgence of the anti-vaccination movement, Brian’s motivation to write the book, and parting thoughts (1:36:45); and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/BrianDeer 

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    #157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux

    #157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux

    In this “Ask Me Anything” (AMA) episode, Peter and Bob take a deep dive into fat flux. They define the major players that impact the flow of fat entering and exiting a fat cell, which determines how much fat a person carries. They discuss the significant influence that insulin has on the net fat balance and explore common strategies, such as fasting and low-carb diets, that have efficacy in the liberation and oxidation of fat from fat cells. Additionally, Bob explains his research process and how he seeks answers to Peter’s challenging questions.

     
    If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #22 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.
     
    We discuss:
    The two main ways to reduce fat mass (1:30); Explaining fat flux—how fat enters and exits a fat cell (9:15); What fat balance looks like (21:15); What net fat influx looks like, and the impact of insulin in lipolysis (24:30); What net fat efflux looks like, and the benefits of fasting to break the hyperinsulinemic cycle (28:30); Exploring why most people with excess body fat will lose fat mass when reducing carbohydrates or eating a ketogenic diet (32:45); Why being in nutritional ketosis does not automatically translate to negative fat flux (fat loss) (42:40); Bob’s approach to scientific research (47:00); The importance of curiosity and a desire to learn (58:30); Bob’s tips and tricks for answering a scientific question in a time-crunch (1:00:00); and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/ama22/ 

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    #156 - Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii’s vulnerable ecosystems

    #156 - Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii’s vulnerable ecosystems

    Jake Muise is an avid hunter, environmentalist, and advocate for the preservation of Hawaii’s natural resources. He is the founder of Maui Nui Venison, a company which actively manages Hawaii’s imbalanced population of axis deer by harvesting them as a food resource. In this episode, Jake tells his unbelievable backstory growing up in Northern Alberta before landing in Hawaii on a volleyball scholarship where he fell in love with the islands and the people. Jake explains how axis deer—a non-native species—were brought to the islands and how they have since become imbalanced to the detriment of Hawaii’s precious ecosystems. He goes on to explain the incredible lengths that his company has taken to ensure the most humane harvesting techniques imaginable resulting in a food source that is as clean and healthful as can be. Additionally, Jake and Peter examine what makes meat from axis deer one of the most nutrient-dense red meats on the planet.
     

    We discuss:
    Upbringing in Northern Alberta, a diet of moose meat, and learning to surf in Nova Scotia (3:35); How volleyball brought Jake to Hawaii where he met the Molokai people (14:00); Jake’s introduction to axis deer (26:30); Pro volleyball in Europe, missing the Olympic team by one spot, and his return to Hawaii (29:00); History of axis deer in Hawaii—how a non-native species came to the islands, and the superpowers that make them so hard to hunt (34:00); A potential catastrophe avoided on The Big Island—The amazing story of how Jake tracked and found axis deer that were secretly brought to The Big Island (52:15); Jake’s work helping ranchers on Maui (1:08:15); The detrimental impact of an imbalanced axis deer population (1:10:30); The incredible evacuation of farm animals from lava-locked land due to a volcano eruption (1:17:00); The creation of Maui Nui Venison—going above and beyond USDA requirements (1:27:00); The most humane way to harvest an animal—the unmatched standards Maui Nui Venison uses to harvest axis deer (1:32:00); Why meat from axis deer is nutritionally superior (and tastes better) than other meats (1:46:00); Why axis deer meat is the best option for those reluctant to eat meat: True nose-to-tail nutrition and ethical harvesting (1:58:15); What a truly balanced population of axis deer on Hawaii would look like (2:06:15); Maui Nui Venison’s charitable work during the COVID crisis (2:12:45); and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/jakemuise

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Customer Reviews

4.7 out of 5
320 Ratings

320 Ratings

finegal1 ,

Great podcast

Interesting, important, thoughtful discussions between Peter and his guests.

Spacebabe08 ,

Okay we get it, you’re smart

As a science- based person I was excited to listen to some of these episodes but too often it just seems to be a competition as to how many acronyms the host can fit into one sentence. Peter Attia although obviously intelligent and well-read comes across as far too eager to impress his guests with his knowledge, unfortunately at the expense of his listeners, who from reading some of the other comments might appreciate his asking questions that shed light on the topic or clarify a point (as a professional interviewer would). Instead he seems like a desperate pupil eager to impress his teachers and often asks ridiculously technical questions with no explanation to the listener as to what he’s talking about and just further plunges what could be an interesting discussion into a maze of technicalities. Also where are the female interviewees, medicine has plenty of them and it might help to mitigate the boys club/vanity project feel of this otherwise well-researched podcast.

Fluorescent_smiles ,

Terry Real

Wow what a great listen. Thanks for sharing a really great interview, I have listened t it twice so far.

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