Chapter Ten: Acid-Base Physiology

References for Chapter 10

We did not mention many references in our discussion today but our listeners may enjoy some of the references below. 

Effects of pH on Potassium: New Explanations for Old Observations - PMC although the focus of this article is on potassium, this elegant review by Aronson and Giebisch reviews intracellular shifts as it relates to pH and K+.

Josh swooned for Figure 10-1 is this right? Which figure was it? which shows the relationship between [H+] and pH. You can find this figure in the original reference from Halperin ML and others, Figure 1 here. Factors That Control the Effect of pH on Glycolysis in Leukocytes 

Here’s Leticia Rolon’s favorite Henderson-Hasselbalch calculator website: ​​Henderson-Hasselbalch Calculator | Buffer Solutions [hint! for this site, use the bicarbonate (or “total CO2”) for A- and PCO2 for the HA] There’s also a cooking tab for converting units! 

Fundamentals of Arterial Blood Gas Interpretation - PMC this review published posthumously from the late but beloved Jerry Yee and his group at Henry Ford Hospital, explores the details and underpinnings of our understandings of arterial blood gas interpretation (and this also addresses how our colleagues in clinical chemistry measure total CO2 - which JC referenced- but JC said “machine” and our colleagues prefer the word “instrument.”)

Amy went deep on bicarbonate in respiratory acidosis. Here are her refs:

Sodium bicarbonate therapy for acute respiratory acidosis

Sodium Bicarbonate in Respiratory Acidosis

Bicarbonate therapy in severe metabolic acidosis

Effect of Intravenous Sodium Bicarbonate on Ventilation, Gas Exchange, and Acid-Base Balance in Patients with Chronic Pulmonary Insufficiency

Bicarbonate Therapy in Severe Metabolic Acidosis | American Society of Nephrology this review article from Sabatini and Kurtzman addresses the issues regarding bicarbonate therapy including theoretical intracellular acidosis. 

Bicarbonate in DKA? Don’t do it: Bicarbonate in diabetic ketoacidosis - a systematic review

Here’s a review  from Bushinsky and Krieger on the effect acidosis on bone

https://www.sciencedirect.com/science/article/abs/pii/S0085253822002174

Here is the primary resource that Anna used in here investigation of meat replacements Nutritional Composition of Novel Plant-Based Meat Alternatives and Traditional Animal-Based Meats

We enjoyed this paper that Dr. Rose references from the Journal of Clinical Investigation 1955 in which investigators infused HCl into nephrectomized dogs and observed changes in extracellular ions. https://www.jci.org/articles/view/103073/pd

We wondered about the amino acids/protein in some available meat alternatives they are explored in this article in the journal Amino Acids: Protein