23 episodes

Hosted by Addiction Medicine Specialist Dr Ferghal Armstrong and Dr Thileepan Naren. With topical discussions on all aspects of addiction medicine. New Episodes weekly.Visit our website for more information and free courses https://www.meducate.com.au/courses

Cracking Addiction Meducate

    • Health & Fitness

Hosted by Addiction Medicine Specialist Dr Ferghal Armstrong and Dr Thileepan Naren. With topical discussions on all aspects of addiction medicine. New Episodes weekly.Visit our website for more information and free courses https://www.meducate.com.au/courses

    LAIB first dose considerations

    LAIB first dose considerations

    Episode 23 of Cracking Addiction explores commencement of patients on LAIB, side effects and risks of LAIB, discussion about precipitated withdrawal and when and how to review patients

    • 20 min
    Long Acting Injectable Buprenorphine (LAIB) - Introduction

    Long Acting Injectable Buprenorphine (LAIB) - Introduction

    An Introduction to Long Acting Injectable Buprenorphine (LAIB)
    Long acting injectable buprenorphine (LAIB) are long acting buprenorphine depot preparations that are injected subcutaneously and provide patients with a sustained release of buprenorphine for the duration of the depot preparation. Currently, two LAIB products are available for the Australian market. They differ in their formulations, administration and pharmacology.
    See blog for further information
    https://www.meducate.com.au/blog
    About Meducate ®
    Meducate provides online education for doctors, clinicians, health professionals and the public.
    See the website to browse the many different talks and courses availablehttps://www.meducate.com.au

    • 18 min
    Methadone pharmacokinetics and interactions

    Methadone pharmacokinetics and interactions

    Episode 21 of Cracking Addiction explores methadone pharmacokinetics, breakdown and interactions within the body and interactions with other drugs.
    Methadone is a drug with a wide variability in its absorption with oral bio-availability ranges from 35% to 100%. This is a significant amount of variability and explains why the same dose of Methadone can impact different patients differently.
    Methadone is metabolised within the liver by the cytochrome P450 enzymes but mainly 3A4. There is a 17-fold inter-individual variation of methadone blood concentration for a given dosage and variations in metabolism account for a large part of this variation. Kinetic interactions influenced by the CYP 450 enzyme can affect plasma methadone levels.
    • Inducers of CYP450 can
    • Accelerate the metabolism of methadone
    • lower methadone plasma levels
    • Precipitate opioid withdrawal
    • Inhibitors of CYP450 can
    • Slow the metabolism of methadone
    • Increase plasma levels
    • Produce opioid toxicity (sedation, overdose)
    Methadone is excreted renally with approximately 10% of drug renally eliminated unchanged. Renal excretion of methadone urinary pH dependent with increased Methadone excretion noted at pH less than 6 and decreased Methadone excretion at higher pH levels.
    About Meducate ®
    Meducate provides online education for doctors, clinicians, health professionals and the public.
    See the website to browse the many different talks and courses availablehttps://www.meducate.com.au

    • 16 min
    Methadone pharmacology and induction

    Methadone pharmacology and induction

    Episode 20 of Cracking Addiction explores methadone, its origins, the pharmacology behind methadone and how to commence a patient on Methadone.
    Methadone is a synthetic long acting mu receptor agonist suitable for the treatment of opioid use disorder. Methadone has a longer plasma half life than morphine (average 22 hours (15-32 hours) vs 2 hours for morphine) which permits once daily supervised dosing.
    https://www.meducate.com.au/blog
    About Meducate ®
    Meducate provides online education for doctors, clinicians, health professionals and the public.
    See the website to browse the many different talks and courses available
    https://www.meducate.com.au

    • 22 min
    Opioid use disorder Post Partum

    Opioid use disorder Post Partum

    Episode 19 of Cracking Addiction explores the management of opioid use disorder in the post partum period.
    Post birth the patient's usual oral methadone dose can be continued in the peripartum and post partum period. There is a theoretical concern in the postpartum period of over-sedation as methadone levels may increase as plasma volume and hepatic clearance normalise post the delivery of the child.
    Latest Blogs
    https://www.meducate.com.au/blog
    About Meducate ®
    Meducate provides online education for doctors, clinicians, health professionals and the public.
    See the website to browse the many different talks and courses available
    https://www.meducate.com.au

    • 11 min
    Opioid use disorder and pregnancy

    Opioid use disorder and pregnancy

    Episode 18 of Cracking Addiction explores the management of opioid use disorder in pregnancy.
    Most women presenting with opioid dependence are of child-bearing age with chaotic drug use predisposes to amenorrhoea. The initiation of opioid substitution therapy (OST) facilitates stability and reinstatement of regular menstrual cycles and thus OST is a risk factor for unplanned pregnancy.
    About Meducate ®
    Meducate provides online education for doctors, clinicians, health professionals and the public.
    See the website to browse the many different talks and courses available
    https://www.meducate.com.au

    • 17 min

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