Innovate and Elevate Sharon Kedar

In this episode, Sharon is joined by Dr. Donald Ingber, Founding Director at Wyss Institute for Biologically Inspired Engineering at Harvard University. 
Dr. Ingber’s commitment to following his passion has led him to countless medical and technological breakthroughs, including organ-chip technology. These incredible chips recreate the structure and function of human organs. Drugs can be administered through organ-chips so that blood impact can be monitored. Once more widely adopted, organ-chip testing will be able to replace animal testing. As Dr. Ingber shares, the results will surpass those of animal testing.
The organ-chip technology already includes women’s health models and holds great promise to revolutionize this under-invested area. Because animals, namely mice, do not have menstrual cycles, their biological environments are already skewed to test any women’s health-related projects. Organ-chips are a great solution to close the data gap. Dr. Ingber shares two projects underway in partnership with the Gates Foundation: to create a cure for bacterial vaginosis and to create a non-hormonal contraceptive. 
Dr. Ingber highlights the importance of nurturing the business side of scientific breakthroughs so that innovations can reach patients. Twenty percent of Harvard’s intellectual property comes out of the Wyss Institute, and both funding and mentorship play crucial roles in that success metric.  
Episode Outline
(00:53) Meet Dr. Donald Inbger 
(02:11) Where Art Meets Science: Inside The Brilliant Mind of Dr. Ingber 
(07:08) What Is Organ-on-a-Chip Technology? 
(13:17) Reimaging Women’s Health with Organ-Chips
(21:11) Think Outside The Box: Bringing Innovation to Life 
Connect with Sharon
Connect with Sharon on LinkedIn: Sharon KedarLearn more about Innovate and Elevate innovateandelevatepodcast.comSubscribe to Innovate and Elevate on YouTubeJoin the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter
Connect with Dr. Ingber
Follow The Wyss Institute on LinkedInLearn more about Emulate, Inc.
Additional Resources
The Wyss Institute The Wyss-Northpond Research And Innovation Alliance First rodent found with a human-like menstrual cycleThe White House Initiative on Women's Health Research
This podcast is produced by the women at The Wave Editing.

Dr. Canan Dagdeviren is Associate Professor of Media Arts and Sciences at the Massachusetts Institute of Technology and Director of the Conformable Decoders research group at the MIT Media Lab. 
In this episode, Dr. Dagdeviren shares the incredible story behind the lab’s wearable, conformable ultrasound breast patch that enables standardized and reproducible breast imaging. They’re developing a first-of-its-kind ultrasound technology for breast tissue scanning and imaging which offers a non-invasive method for tracking real-time dynamic changes of soft tissue. This technology is meant to be used in adjunct with current screening methods, addressing the various barriers that many women at high risk for breast cancer face when it comes to breast screening. 
Driven by her aunt's battle with breast cancer, Dr. Dagdeviren embarked on a journey to innovate breast cancer screening solutions. In our conversation, she shares the current prototype for The Conformable Ultrasound Breast Patch (CUSBr-Patch), detailing the logistics of how it works and how she envisions the patient experience. 
Beyond product innovation, Dr. Dagdeviren emphasizes the need for elevating standards in clinical trials. She outlines the commitment she and her team have made to implement a diverse patient-centric approach in their lab. 
If you are a woman at high risk for breast cancer and currently on a breast cancer screening plan, please consider applying to be a part of the Conformable Decoders’ clinical trial. You can email Dr. Dagdeviren at canand@mit.edu for more information. 
Connect with Sharon
Connect with Sharon on LinkedIn: Sharon KedarLearn more about Innovate and Elevate innovateandelevatepodcast.comSubscribe to Innovate and Elevate on YouTubeJoin the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter
Connect with Dr. Dagdeviren: 
Connect with Dr. Dagdeviren on LinkedInLearn more about Conformable Decoders
Additional Resources
Conformable Ultrasound Breast Patch (CUSBr-Patch) For Deep Tissue Scanning And ImagingThe Ultrasound Breast Patch Prototype VideoMIT Future Founders BBC 100 Women 2023: Canan Dagdeviren

Credits
This podcast is produced by the women at The Wave Editing.

On this episode of Innovate and Elevate, Sharon is joined by Dr. Rachel Brem. Dr. Brem is board-certified in Diagnostic Radiology. She is a Professor of Radiology, the Vice Chair of Radiology, and Director of Breast Imaging & Intervention at The George Washington University School of Medicine & Health Sciences.
In this conversation, Dr. Brem shares how to understand your risk for breast cancer and her recommended imaging strategy for those with dense breast tissue. She also emphasizes the importance of co-creating a personalized healthcare plan with a doctor that suits your needs. 
Note that other risk factors may influence your individual situation. For a comprehensive understanding, explore additional resources at breastcancer.org/risk/risk-factors. 
Cancer in a dense breast is exponentially more difficult to detect in a mammogram, which is why Dr. Brem is a strong advocate for breast ultrasound and/or MRI. In fact, breast imaging specialists can find 25% more cancerous cells with ultrasound screening in women with dense breasts than they can with mammography. 
Dr. Brem doesn’t believe in a one-size-fits-all breast healthcare approach. Instead, she urges women to get the knowledge they need to make the right choices for their health and find a doctor that can tailor a plan for their unique needs. 
Finally, Dr. Brem shares her hope in the technologies currently in development to help detect cancer before imaging, such as liquid biopsy and breath analysis. 
Connect with Sharon
Connect with Sharon on LinkedIn: Sharon KedarLearn more about Innovate and Elevate innovateandelevatepodcast.comSubscribe to Innovate and Elevate on YouTubeJoin the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter
Connect with Dr. Rachel Brem
Connect with Dr. Rachel Brem on LinkedIn: Dr. Rachel Brem
Additional Resources
No Longer Radical by Dr. Rachel Brem and Dr. Christy TealBrem Foundation to Defeat Breast CancerCheckMate by The Brem FoundationTyrer-Cuzick Risk Assessment CalculatorBreast Cancer Risk Assessment Tool (The Gail Model)
Glossary
Prophylactic mastectomy: A prophylactic mastectomy is surgery to remove one or both breasts to lower the chances of getting breast cancer.BRCA mutation: A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumor suppressor genes. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome. Liquid biopsy: A liquid biopsy is a test that checks for signs of diseases by analyzing a small sample...

On this episode of Innovate and Elevate, Sharon is joined by Dr. Janet Storella, Medical Director of Breastlink Maryland at RadNet. Dr. Storella is a breast imaging specialist and a board-certified diagnostic radiologist with over 40 years of radiology experience. 
In this conversation, Dr. Storella shares deeper insight into the practice and art of mammography, contemporary issues in the field, spaces for improvement, and aspects of mammography where quality makes all the difference.
There are differing opinions on when women should start annual mammography screening, but Dr. Storella emphasizes that understanding one’s risk factors is key to determining when to start screening and collaborating on a personalized plan with their doctor. She highlights how diagnostic imaging centers are working on lowering barriers to compliance, particularly through strategic partnerships like RadNet’s with Walmart. 
Dr. Storella shares that determining if a mammogram shows cancer can be extremely difficult because of the variable nature of breast tissue. She expands on her experiences using AI to interpret test results and the journey to convincing insurance companies to cover this impactful new practice. Even though mammograms are continuously critiqued by doctors and patients alike, Dr. Storella reminds us that ultimately mammograms save lives, help individuals detect cancer earlier, and are what we have available right now.
Finally, Dr. Storella explains the technical factors that contribute to high-quality breast imaging and why an uncomfortable mammogram is a positive sign of adequate compression. She also highlights the rigorous standards that mammography technologists are required to meet, reinforcing her message that breast cancer screening is an advanced and highly artful skill. 
Connect with Dr. Storella
Connect with Dr. Storella on LinkedIn: Dr. Janet Storella  
Connect with Sharon
Connect with Sharon on LinkedIn: Sharon KedarLearn more about Innovate and Elevate innovateandelevatepodcast.comSubscribe to Innovate and Elevate on YouTubeJoin the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter
Additional Resources
American Cancer Society - Survival Rate for Breast CancerMammogramNow™ at WalmartDeepHealth, a RadNet AI subsidiaryDr. Storella Named 2023 Top DoctorTyrer-Cuzick Risk Assessment CalculatorBreast Cancer Risk Assessment Tool (The Gail Model)The...

On this episode of Innovate and Elevate, Sharon is joined by Dr. Kathyrn Rexrode, Chief of the Division of Women’s Health in the Department of Medicine at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School. 
In their conversation, Dr. Rexrode discusses the progression in her career from experiencing imposter syndrome to stepping into her confidence and authority as a physician, professor, and woman in leadership. She also highlights how rejecting a scarcity mindset and supporting other women professionally has helped bolster her self-confidence. In Dr. Rexrode’s words, “The more we support one another, the more collective success we’ll have.” 
Dr. Rexrode describes her nonlinear 26-year path to becoming a full professor at Harvard Medical School. For anyone wanting to start a family and become a full-time professor, or generally devote themselves to climbing the career ladder, Dr. Rexrode emphasizes that there isn’t a one-size-fits-all approach. Sharon and Dr. Rexrode share how they navigate motherhood and career growth, which often requires a willingness to redefine what success looks like on an individual level. 
Finally, Dr. Rexrode brings listeners back to the early days of her career and the shocking realities that sparked her passion for improving healthcare standards for women. She continues that mission today, encouraging everyone to treat their body with the same respect, care, and attention they would if they were pregnant. 
Guest Bio
Dr. Kathryn Rexrode serves as Chief of the Division of Women’s Health in the Department of Medicine at Brigham and Women’s Hospital and is a Professor of Medicine at Harvard Medical School. She is a board-certified general internist with a predominantly women’s health practice as a primary care physician at the BWH Gretchen S. and Edward A. Fish Center for Women’s Health. 
Connect with Dr. Rexrode 
Connect with Dr. Rexrode on LinkedIn: Dr. Kathryn Rexrode
Connect with Sharon
Connect with Sharon on LinkedIn: Sharon KedarSubscribe to Innovate and Elevate on YouTube.Learn more about Innovate and Elevate innovateandelevatepodcast.comJoin the newsletter to receive the latest episodes in your inbox: Innovate and Elevate Newsletter
Additional Resources
Women ≠ Tiny Men | Brigham Magazine
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Credits
This podcast is produced by the women at The Wave Editing.

Behind every pioneering idea, method, and device is a fellow human or humans. A trailblazer who is daring enough to ask the questions that push the boundaries and make the impossible possible.
Host Sharon Kedar, MBA, CFA, talks with these change agents on the Innovate and Elevate podcast.  In each episode, you hear from top doctors, scientists, leaders, and innovators on how they are trailblazing within the world at large and within their own lives.  
As the co-founder of Northpond Ventures, a multi-billion-dollar science-driven venture capital firm, Sharon is frequently rethinking the limits of what is possible. 
Season one focuses on women’s health with the aim of helping women lead our healthiest lives. You’ll hear from leading experts such as Dr. Kathryn Rexrode, Division Chief, Women’s Health at Harvard’s Brigham Hospital.
Tune in wherever you listen to podcasts, and please remember to follow Innovate and Elevate on Apple Podcasts or Spotify so you can be the first to know when new episodes are available.
The views and opinions of the host and podcast guests are their own professional opinions and may not represent the views of Northpond Ventures.