50 Min.
#15 Atypical T cell responses: HLA-E Immunology (Sir Andrew McMichael) Holobiont
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- Wissenschaft
Sir Andrew McMichael is a Professor of Immunology at the University of Oxford and previously Director of the Weatherall Institute of Molecular Medicine. He is a fellow of the Royal Society and Academy of Medical Sciences and has been a leader in human immunology for decades, notably focusing on responses to viral infections including influenza and HIV.
We discuss:
Prof McMichael's career in immunology spanning from his work in the 1980s on HLA restriction and recognition of viral peptides to the study of a HLA-E, an atypical MHC-Ib molecule that is involved in immunosurveillance
How HLA-E is involved in detection of the "missing self" by Natural Killer (NK) cells
The discovery of a class of CD8+ T cells recognising HLA-E complexes and their role in protection against SIV infection
The opportunities and unanswered questions in HLA-E immunobiology
Advice to scientists
Sir Andrew McMichael is a Professor of Immunology at the University of Oxford and previously Director of the Weatherall Institute of Molecular Medicine. He is a fellow of the Royal Society and Academy of Medical Sciences and has been a leader in human immunology for decades, notably focusing on responses to viral infections including influenza and HIV.
We discuss:
Prof McMichael's career in immunology spanning from his work in the 1980s on HLA restriction and recognition of viral peptides to the study of a HLA-E, an atypical MHC-Ib molecule that is involved in immunosurveillance
How HLA-E is involved in detection of the "missing self" by Natural Killer (NK) cells
The discovery of a class of CD8+ T cells recognising HLA-E complexes and their role in protection against SIV infection
The opportunities and unanswered questions in HLA-E immunobiology
Advice to scientists
50 Min.