How to STOP Living in Fear and Find Your Purpose in Life | Ryan Holiday

The Human Upgrade with Dave Asprey

Fear is quietly running your life—and it’s holding you back from the purpose and success you deserve. In this episode, we revisit Dave chatting with one of the keynote speakers for the Biohacking Conference 2025, Ryan Holiday, the bestselling author of Courage Is Calling, to tackle the one thing standing between you and your potential: fear. 

Why should you listen? Because fear is the root cause of procrastination, self-doubt, and the endless excuses that keep you stuck. Ryan reveals why courage isn’t just about bravery—it’s about making the hard choices that align with your purpose, even when the stakes are high. 

Drawing on powerful examples from history and modern life, Ryan explains how fear can be transformed into a catalyst for action and why embracing discomfort is the key to unlocking true freedom. If you’ve ever felt paralyzed by uncertainty, this episode will give you the tools and perspective to take control, face your fears, and create the life you’re meant to live. 

Why This Episode Matters: 

• You’ll discover how fear sneaks into your decisions—and how to stop it 

• Learn why courage is the ultimate skill for success and fulfillment 

• Get actionable advice to break through self-imposed limits 

• Understand the psychology of fear and how to use it as fuel 

• Hear real-life stories of people who overcame fear to achieve greatness 

Resources:  

2025 Biohacking Conference – https://biohackingconference.com/2025 

Ryan Holiday’s Website – https://ryanholiday.net 

Daily Stoic Website – https://dailystoic.com/ 

Ryan Holiday’s Book: Courage Is Calling – https://a.co/d/czEfCXC 

Ryan Holiday’s Instagram – https://www.instagram.com/ryanholiday 

Danger Coffee – https://dangercoffee.com 

Dave Asprey’s Website – https://daveasprey.com 

Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books 

Dave Asprey’s Linktree – https://linktr.ee/daveasprey 

Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com 

Own an Upgrade Labs – https://ownanupgradelabs.com 

Upgrade Labs – https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com 

Sponsors 

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 

-Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula. 

Timestamps: 

00:00 – Intro 

00:44 – Discussing Ryan Holiday’s Work 

02:37 – The Concept of Courage 

08:09 – Fear and Courage in History 

12:41 – Stoic Philosophy and Modern Applications 

21:50 – The Four Virtues and Their Interrelation 

28:39 – Challenges in Admitting Mistakes 

35:21 – Navigating Business Risks During a Pandemic 

36:44 – The Essence of Courage in Business and Life 

37:03 – Reed Hastings and the Duality of Courage 

40:06 – Moral Courage: Lessons from History 

43:35 – The Debate on Mandates and Personal Freedom 

45:22 – Balancing Public Health and Individual Rights 

58:29 – The Role of Responsibility in Society 

01:09:01 – The Importance of Intellectual Courage 

01:12:04 – Reaching Audiences in a Noisy World 

01:13:27 – Final Thoughts and Encouragement 

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