10 épisodes
Dive into Imaging Science European Society for Molecular Imaging (ESMI)
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- Sciences
This is the Podcast of the Europen Society for Molecular Imaging (ESMI). Pour yourself a nice glass of wine and join us as we delve into the recent literature, and perhaps learn a little from the minds that have shaped the field. The premise is really simple: Each time we invite one senior academic to discuss their favourite publication from the recent literature. We’ll find out what caught their eye, and why it is worth taking a closer look at this particular publication. Along the way, we will learn their publication strategies and possibly even glimpse into the future of this amazing field of research. Music “In this Life”, Composer: Guido Jäger, Musicians: Andreas Jacobs – violin, Jacob Niller – accordion, Wolfgang Platen – contrabass
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In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status - A pilot study combining PET and deuterium metabolic imaging
GUEST: Kevin Brindle, CambridgeIn this episode we welcome the one and only Kevin Brindle from University of Cambridge.During his long and illustrious career, Kevin pioneered hyperpolarized magnetic resonance spectroscopy as a method to map metabolic flux in cancer and other diseases, with implications for treatment response monitoring.We explore how deuterium imaging and [18F]FDG PET can be used to track the metabolic changes that occur soon after stroke and during the recovery phase. We disc...
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Visualizing cell–cell communication using synthetic notch activated MRI
GUEST: Mikhail Shapiro, PasadenaIn this episode we welcome our famous guest Mikhail Shapiro from Caltech. Mikhail exquisitely combines ultrasound with synthetic biology for gene regulation, imaging, and therapy - and Synthetic biology is surely the common thread in this podcast edition.We discover how an engineered receptor and an intracellular signalling domain, known as ‘synNotch’ can be used to visualise cell-cell communication in vivo. And how this system can be used to identify immune-ca...
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Albumin-Binding and Conventional PSMA Ligands in Combination with 161Tb
GUEST: Jason Lewis, New YorkIn this episode we discuss and learn about new PSMA-binding ligands with 161Tb, their biodistribution, dosimetry, preclinical therapy, and their comparison with conventional PSMA ligands. Our guest is one of the leading scientists in radiochemistry for cancer detection and therapy, the wonderful Jason Lewis. We talk about the importance of using 161Tb - this novel radionuclide for radioligand therapy - and its favorable decay characteristics as compared to 177...
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Glymphatic influx and clearance are accelerated by neurovascular coupling
GUEST: Annemie Van Der Linden, AntwerpIn this edition of ‘Dive into Imaging Science’ we discuss the brain and the mechanisms that it employs to clear unwanted waste material whilst we sleep with our former ESMI President and Emeritus Professor Annemie Van Der Linden - an outstanding figure and incomparable scientist.We learn how closely coupled this system - known as the glymphatics - is to blood circulation, and how physical stimulation can enhance glymphatic flow in anaesthetised but not aw...
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First-in-human study of the radioligand 68Ga-N188 targeting nectin-4 for PET/CT imaging of advanced urothelial carcinoma
GUEST: Elisabeth de Vries, GroningenIn this episode we talk about nectin-4 - an emerging biomarker for cancer diagnosis and therapy - with one of the most influential and distinguished scientists in medical oncology, Elisabeth de Vries. We talk about the first-in-human study of a radioligand that can target nectin-4 and learn what medical oncologists need to get out from imaging data so that these powerful tools continue to make an impact on patient outcomes. We learn about the importance and...
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Development of a Lensless Radiomicroscope for Cellular-Resolution Radionuclide Imaging
GUEST: Bernd Pichler, TübingenIn this episode we learn how a new lensless microscope, costing just $100 (!), can be used to evaluate radiotracer retention in cells, and discuss potential applications for this revolutionary new technology with our famous guest Bernd Pichler. We discuss how this, and other technologies, could be used to assess the heterogeneous cell populations of the tumour microenvironment and identify cell senescence using new radiotracers developed in Bernd’s lab.Selected P...