Medscape InDiscussion: Major Depressive Disorder Medscape

Drs Madhukar Trivedi and Manish Jha discuss the use of a "primary care first" model to screen and treat depression, emphasizing measurement-based care that can triage to specialty care when needed.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984454). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Depression https://emedicine.medscape.com/article/286759-overview
USPSTF Screening for Depression in Adults https://www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/depression-in-adults-screening
Depression Screening Patterns, Predictors, and Trends Among Adults Without a Depression Diagnosis in Ambulatory Settings in the United States https://pubmed.ncbi.nlm.nih.gov/29983110/
Primary versus Specialty Care Outcomes for Depressed Outpatients Managed With Measurement-Based Care: Results From STAR*D https://pubmed.ncbi.nlm.nih.gov/18247097/
The PHQ-9: Validity of a Brief Depression Severity Measure https://pubmed.ncbi.nlm.nih.gov/11556941/
VitalSign6: A Primary Care First (PCP-First) Model for Universal Screening and Measurement-Based Care for Depression https://pubmed.ncbi.nlm.nih.gov/31091770/
A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7 https://pubmed.ncbi.nlm.nih.gov/16717171/
Prevalence and Impact of Diagnosed and Undiagnosed Depression in the United States https://pubmed.ncbi.nlm.nih.gov/36134073/
FDA Approves First Treatment for Post-partum Depression
https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-post-partum-depression

Drs Madhukar Trivedi and Lorenzo Norris address the issues of race, equity in care, and the importance of cultural competence when treating patients with major depressive disorder.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984455). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Depression https://emedicine.medscape.com/article/286759-overview
Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) https://www.psychiatry.org/psychiatrists/practice/dsm
The Cultural Formulation Interview: Building the Case for Cultural Competence in Clinical Care https://pubmed.ncbi.nlm.nih.gov/36722093/
Shared Decision Making https://www.medscape.org/shareddecisionmaking
Promoting Collaborative Psychiatric Care Decision-Making in Community Mental Health Centers: Insights From a Patient-Centered Comparative Effectiveness Trial https://pubmed.ncbi.nlm.nih.gov/33119363/
Structured Clinical Interview for the DSM https://www.appi.org/products/structured-clinical-interview-for-dsm-5-scid-5
Psychometric Properties of Structured Clinical Interview for DSM-5 Disorders-Clinician Version (SCID-5-CV) https://pubmed.ncbi.nlm.nih.gov/33729681/
The Patient Health Questionnaire-2: Validity of a Two-Item Depression Screener https://pubmed.ncbi.nlm.nih.gov/14583691/
The PHQ-9: Validity of a Brief Depression Severity Measure https://pubmed.ncbi.nlm.nih.gov/11556941/

Drs Madhukar Trivedi and Anita Clayton discuss how to approach patients with sexual dysfunction who are being treated for major depressive disorder.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984459). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Depression https://emedicine.medscape.com/article/286759-overview
Treatment-Emergent Sexual Dysfunction Related to Antidepressants: A Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/19440080/
Citizen Petition: Sexual Side Effects of SSRIs and SNRIs https://pubmed.ncbi.nlm.nih.gov/29733031/
Association of Major Depression With Sexual Dysfunction in Men https://pubmed.ncbi.nlm.nih.gov/23645187/
The Changes in Sexual Functioning Questionnaire (CSFQ): Development, Reliability, and Validity https://pubmed.ncbi.nlm.nih.gov/9493486/
Structured Review of the Use of the Arizona Sexual Experiences Scale in Clinical Settings https://pubmed.ncbi.nlm.nih.gov/32236977/
Hypoactive Sexual Desire Disorder: A Review of Epidemiology, Biopsychology, Diagnosis, and Treatment https://pubmed.ncbi.nlm.nih.gov/27872021/
Erectile Dysfunction https://pubmed.ncbi.nlm.nih.gov/31030826/
Sexual Dysfunction With Major Depressive Disorder and Antidepressant Treatments: Impact, Assessment, and Management https://pubmed.ncbi.nlm.nih.gov/35255754/
Overview of the Rapid Antidepressant Effects Observed in the Zuranolone Clinical Development Program https://journals.lww.com/greenjournal/Abstract/2022/05001/Overview_of_the_Rapid_Antidepressant_Effects.161.aspx
Flibanserin prescribing information https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf

Drs Madhukar Trivedi and Jeffrey Strawn discuss the impact of socioeconomic factors on outcomes of treatments in patients with major depressive disorder, including factors such as unemployment, race, sex, and age.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984460). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Depression https://emedicine.medscape.com/article/286759-overview
Center for Clinical and Translational Science and Training (CCTST) https://www.cctst.org/
Socioeconomic Predictors of Treatment Outcomes Among Adults With Major Depressive Disorder https://pubmed.ncbi.nlm.nih.gov/35354325/
Cortisol and Major Depressive Disorder-Translating Findings From Humans to Animal Models and Back https://pubmed.ncbi.nlm.nih.gov/32038323/
Bayesian Hierarchical Models https://pubmed.ncbi.nlm.nih.gov/30535206/
The Impact of Age on Antidepressant Response: A Mega-Analysis of Individuals With Major Depressive Disorder https://pubmed.ncbi.nlm.nih.gov/36774767/
The Effectiveness of Individual Interpersonal Psychotherapy as a Treatment for Major Depressive Disorder in Adult Outpatients: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/23312024/
Cognitive Behavioral Therapy for Depression https://emedicine.medscape.com/article/2094696-overview
Depression and Psychodynamic Psychotherapy https://pubmed.ncbi.nlm.nih.gov/28614491/
Selective Serotonin Reuptake Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK554406/
Cytochrome p450 Structure, Function and Clinical Significance: A Review https://pubmed.ncbi.nlm.nih.gov/28124606/ 
Optimizing Drug Selection in Psychopharmacology Based on 40 Significant CYP2C19- and CYP2D6-Biased Adverse Drug Reactions of Selective Serotonin Reuptake Inhibitors https://pubmed.ncbi.nlm.nih.gov/31616600/

Drs Madhukar H. Trivedi and Christoph U. Correll discuss the predictors of suicidal ideation, attempt, and death as well as how to address the topic of suicidality with patients and their loved ones.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984464). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Depression https://emedicine.medscape.com/article/286759-overview
Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative Studies https://pubmed.ncbi.nlm.nih.gov/34603096/
Twelve-Month Prevalence of and Risk Factors for Suicide Attempts in the World Health Organization World Mental Health Surveys https://pubmed.ncbi.nlm.nih.gov/20816034/
Persistent Depressive Disorder https://www.ncbi.nlm.nih.gov/books/NBK541052/
Risk and Protective Factors for Suicide and Suicidal Behavior https://www.div12.org/wp-content/uploads/2012/10/Suicide-Risk-Factors-with-Graphics-Div12.pdf
Prevention of Suicide by Clozapine in Mental Disorders: Systematic Review https://pubmed.ncbi.nlm.nih.gov/36640481/
Lithium Suicide Prevention: A Brief Review and Reminder https://pubmed.ncbi.nlm.nih.gov/30834169/
Trauma-Focused Psychotherapies for Post-Traumatic Stress Disorder: A Systematic Review and Network Meta-analysis https://pubmed.ncbi.nlm.nih.gov/34473342/
Intranasal Esketamine and Current Suicidal Ideation With Intent in Major Depression Disorder: Beat the Clock, Save a Life, Start a Strategy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203410/
Dextromethorphan/Bupropion (Rx) https://reference.medscape.com/drug/auvelity-dextromethorphan-bupropion-4000211
Status Update on the Sheehan-Suicidality Tracking Scale (S-STS) 2014 https://pubmed.ncbi.nlm.nih.gov/25520892/
Psychometric Properties of the Beck Depression Inventory-II: A Comprehensive Review https://pubmed.ncbi.nlm.nih.gov/24402217/
The 9-Item Concise Health Risk Tracking – Self-Report (CHRT-SR9) Measure of Suicidal Risk: Performance in Adult Primary Care Patients https://pubmed.ncbi.nlm.nih.gov/36865066/
Maximizing the Adequacy of Medication Treatment in Controlled Trials and Clinical Practice: STAR(*)D Measurement-Based Care https://pubmed.ncbi.nlm.nih.gov/17406651/
Psychometrics of the Self-Report Concise Associated Symptoms Tracking Scale (CAST-SR): Results From the STRIDE (CTN-0037) Study https://pubmed.ncbi.nlm.nih.gov/29325238/
Mechanisms of Action and Clinical Efficacy of NMDA Receptor Modulators in Mood Disorders https://pubmed.ncbi.nlm.nih.gov/28711661/
Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics https://pubmed.ncbi.nlm.nih.gov/30262987/
Zuranolone in Major Depressive Disorder: Results From MOUNTAIN-A Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial https://pubmed.ncbi.nlm.nih.gov/36811520/
GABA Receptor Positive Allosteric Modulators https://www.ncbi.nlm.nih.gov/books/NBK554443/#
Conjoint Therapy https://dictionary.apa.org/conjoint-therapy

Drs Madhukar Trivedi and Leanne M. Williams discuss defining subtypes and biotypes for depression to tailor more personalized treatments of major depressive disorder.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984466). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Depression https://emedicine.medscape.com/article/286759-overview
Defining Biotypes for Depression and Anxiety Based on Large-scale Circuit Dysfunction: A Theoretical Review of the Evidence and Future Directions for Clinical Translation https://pubmed.ncbi.nlm.nih.gov/27653321/
Depression From a Precision Mental Health Perspective: Utilizing Personalized Conceptualizations to Guide Personalized Treatments https://pubmed.ncbi.nlm.nih.gov/34045980/
Acute and Longer-term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report https://pubmed.ncbi.nlm.nih.gov/17074942/
Depression Is the Leading Cause of Disability Around the World https://pubmed.ncbi.nlm.nih.gov/28418490/
Mapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety https://pubmed.ncbi.nlm.nih.gov/34482948/
Precision Psychiatry: A Neural Circuit Taxonomy for Depression and Anxiety https://pubmed.ncbi.nlm.nih.gov/27150382/
Childhood Trauma Predicts Antidepressant Response in Adults With Major Depression: Data From the Randomized International Study to Predict Optimized Treatment for Depression https://pubmed.ncbi.nlm.nih.gov/27138798/
Effect of Antidepressant Treatment on Cognitive Impairments Associated With Depression: A Randomised Longitudinal Study https://pubmed.ncbi.nlm.nih.gov/26995298/
Neuromodulation Surgery for Psychiatric Disorders https://emedicine.medscape.com/article/1343677-overview#a10
Use of Transcranial Magnetic Stimulation for Depression https://pubmed.ncbi.nlm.nih.gov/31355095/
Understanding Emotions: Origins and Roles of the Amygdala https://pubmed.ncbi.nlm.nih.gov/34072960/
Digital Therapeutics for Mental Health: Is Attrition the Achilles Heel? https://pubmed.ncbi.nlm.nih.gov/35982936/