Medscape InDiscussion: Moderate to Severe Asthma Medscape

Join Drs Mike Wechsler and Josh Kosowsky as they work through the management of a patient presenting with moderate to severe asthma in the ER.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987112). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Asthma https://emedicine.medscape.com/article/296301-overview
National Center for Health Statistics - Asthma https://www.cdc.gov/nchs/fastats/asthma.htm
Beta2-Agonists https://www.ncbi.nlm.nih.gov/books/NBK542249/
Noninvasive Ventilation Procedures https://emedicine.medscape.com/article/1417959-overview
The Use of Heliox in Critical Care https://pubmed.ncbi.nlm.nih.gov/25024941/
High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients With Severe Bronchial Asthma Complicated With Respiratory Failure https://pubmed.ncbi.nlm.nih.gov/32211084/
Anti-IL-5 Therapies for Asthma https://pubmed.ncbi.nlm.nih.gov/35838542/
Recent Advances in the Inhibition of the IL-4 Cytokine Pathway for the Treatment of Allergen-Induced Asthma https://pubmed.ncbi.nlm.nih.gov/34948449/
Targeting TSLP in Asthma https://pubmed.ncbi.nlm.nih.gov/35685846/
National Hospital Ambulatory Medical Care Survey: 2020 Emergency Department Summary Tables https://www.cdc.gov/nchs/data/nhamcs/web_tables/2020-nhamcs-ed-web-tables-508.pdf
FDA Approves Drug Combination Treatment for Adults With Asthma https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-drug-combination-treatment-adults-asthma

Join Drs Mike Wechsler and Mario Castro as they discuss the diagnosis and treatment of allergic asthma in the clinic.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987113). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Asthma: A Syndrome Composed of Heterogeneous Diseases https://pubmed.ncbi.nlm.nih.gov/18681077/
Allergic Endotypes and Phenotypes of Asthma https://pubmed.ncbi.nlm.nih.gov/32037107/
Comorbidities and the Impact of Atopic Dermatitis https://pubmed.ncbi.nlm.nih.gov/31034875/
Biomarkers for Diagnosis and Prediction of Therapy Responses in Allergic Diseases and Asthma https://pubmed.ncbi.nlm.nih.gov/32893900/
2023 GINA Report for Asthma https://pubmed.ncbi.nlm.nih.gov/37302397/
Pulmonary Function Testing in the Diagnosis of Asthma: A Population Study https://pubmed.ncbi.nlm.nih.gov/22030804/
Using Fractional Exhaled Nitric Oxide Measurement in Clinical Asthma Management https://pubmed.ncbi.nlm.nih.gov/34673021/
2020 NAEPP Guidelines Update and GINA 2021-Asthma Care Differences, Overlap, and Challenges https://pubmed.ncbi.nlm.nih.gov/34718214/
Understanding the Key Issues in the Treatment of Uncontrolled Persistent Asthma With Type 2 Inflammation https://pubmed.ncbi.nlm.nih.gov/33542055/
2020 Focused Updates to the Asthma Management Guidelines: A Report From the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group https://pubmed.ncbi.nlm.nih.gov/33280709/
Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial https://pubmed.ncbi.nlm.nih.gov/21536936/
Dupilumab Efficacy in Patients With Uncontrolled, Moderate-to-Severe Allergic Asthma https://pubmed.ncbi.nlm.nih.gov/31521831/
Efficacy of Tezepelumab in Patients With Evidence of Severe Allergic Asthma: Results From the Phase 3 NAVIGATOR Study https://pubmed.ncbi.nlm.nih.gov/36507576/
The Evolving Landscape of Immunotherapy for the Treatment of Allergic Conditions https://pubmed.ncbi.nlm.nih.gov/37170653/
Omalizumab Prescribing Information https://www.gene.com/download/pdf/xolair_prescribing.pdf

The field of asthma genetics and pharmacogenetics is rapidly evolving. What does that mean for patients experiencing asthma? Join Drs Michael Wechsler and Benjamin Raby as they discuss.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987114). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Asthma https://emedicine.medscape.com/article/296301-overview
Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy https://pubmed.ncbi.nlm.nih.gov/31178722/
The Human Genome Project https://www.genome.gov/human-genome-project
Methacholine Challenge Test https://www.ncbi.nlm.nih.gov/books/NBK547716/
Obesity and Asthma https://pubmed.ncbi.nlm.nih.gov/33032723/
The Cytokines of Asthma https://pubmed.ncbi.nlm.nih.gov/30995510/
Bronchial Allergen Challenge of Patients With Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa https://pubmed.ncbi.nlm.nih.gov/30185520/
ORMDL3 and Allergic Asthma: From Physiology to Pathology https://pubmed.ncbi.nlm.nih.gov/31376405/
New Insights Relating Gasdermin B to the Onset of Childhood Asthma https://pubmed.ncbi.nlm.nih.gov/35580164/
Hereditary and Acquired Ichthyosis Vulgaris https://emedicine.medscape.com/article/1112753-overview
The Role of Filaggrin in Atopic Dermatitis and Allergic Disease https://pubmed.ncbi.nlm.nih.gov/31622670/
Precision Medicine in Childhood Asthma https://pubmed.ncbi.nlm.nih.gov/30649013/

Join Drs Mike Wechsler and Anthony Gerber as they discuss how rapid advances in technology are changing asthma management. What's working? What's not? Tune in to find out.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987115). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Digital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective https://pubmed.ncbi.nlm.nih.gov/34379316/
Mobile Health and Inhaler-Based Monitoring Devices for Asthma Management https://pubmed.ncbi.nlm.nih.gov/31706485/
Apps for Asthma Self-Management: A Systematic Assessment of Content and Tools https://pubmed.ncbi.nlm.nih.gov/23171675/
Effectiveness of a Digital Inhaler System for Patients With Asthma: A 12-Week, Open-Label, Randomized Study (CONNECT1) https://pubmed.ncbi.nlm.nih.gov/36038131/
Artificial Intelligence: Exploring the Future of Innovation in Allergy Immunology https://pubmed.ncbi.nlm.nih.gov/37160554/

Join Drs Michael Wechsler and Ian D. Pavord as they discuss the future of asthma care. Where will we be in 5 or even 10 years from now? What breakthroughs are on the horizon? Tune in to find out.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987116). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Asthma https://emedicine.medscape.com/article/296301-overview
Type 2 Inflammation in Asthma and Other Airway Diseases https://pubmed.ncbi.nlm.nih.gov/35923421/
Considering Biomarkers in Asthma Disease Severity https://pubmed.ncbi.nlm.nih.gov/34942235/
Epithelial Cell Alarmin Cytokines: Frontline Mediators of the Asthma Inflammatory Response https://pubmed.ncbi.nlm.nih.gov/36311787/
Targeting TSLP in Asthma https://pubmed.ncbi.nlm.nih.gov/35685846/
The Immunomodulatory Effects of Macrolides-A Systematic Review of the Underlying Mechanisms https://pubmed.ncbi.nlm.nih.gov/29593707/
NICE (National Institute for Health and Care Excellence) https://www.nice.org.uk/
Preventing Asthma in High Risk Kids (PARK) With Omalizumab: Design, Rationale, Methods, Lessons Learned and Adaptation https://pubmed.ncbi.nlm.nih.gov/33242697/
Mechanisms of Non–Type 2 Asthma https://pubmed.ncbi.nlm.nih.gov/33160187/
Effect of Azithromycin on Asthma Exacerbations and Quality of Life in Adults With Persistent Uncontrolled Asthma (AMAZES): A Randomised, Double-blind, Placebo-Controlled Trial https://pubmed.ncbi.nlm.nih.gov/28687413/
Bronchial Thermoplasty https://emedicine.medscape.com/article/2094272-overview
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network https://preciseasthma.org/preciseweb/
KIT Inhibition by Imatinib in Patients With Severe Refractory Asthma https://pubmed.ncbi.nlm.nih.gov/28514613/
JAK Inhibitors for Asthma https://pubmed.ncbi.nlm.nih.gov/34625142/
Optimizing Asthma Management: Role of Long-Acting Muscarinic Antagonists https://pubmed.ncbi.nlm.nih.gov/35933228/
Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy (FF/UMEC/VI) Versus FF/VI in Patients With Inadequately Controlled Asthma (CAPTAIN): A Double-blind, Randomised, Phase 3A Trial https://pubmed.ncbi.nlm.nih.gov/32918892/
Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes https://pubmed.ncbi.nlm.nih.gov/35549845/
Claude Bernard, the Founder of Modern Medicine https://pubmed.ncbi.nlm.nih.gov/35626738/

When is it time to send a child with an asthma exacerbation to the emergency department? Join Drs Michael Wechsler and Todd Florin as they discuss.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987117). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Asthma https://emedicine.medscape.com/article/296301-overview
Pediatric Asthma https://emedicine.medscape.com/article/1000997-overview
Medscape InDiscussion: Pediatric Pneumonia Podcast https://www.medscape.com/viewarticle/987058
Medscape InDiscussion: Team Effort: A Multidisciplinary Approach to Severe Asthma Control https://www.medscape.com/viewarticle/969689
Medscape InDiscussion: Challenges and Opportunities: Treatment and Prevention of Moderate to Severe Childhood Asthma https://www.medscape.com/viewarticle/969691
Medscape InDiscussion: Emergency! Managing Asthma in the ER https://www.medscape.com/viewarticle/987112
CDC Asthma National Data https://www.cdc.gov/asthma/most_recent_national_asthma_data.htm
Pediatric Acute Asthma Scoring Systems: A Systematic Review and Survey of UK Practice https://pubmed.ncbi.nlm.nih.gov/33145551/
PRAM Score for Pediatric Asthma Exacerbation Severity https://reference.medscape.com/calculator/534/pram-score-for-pediatric-asthma-exacerbation-severity
Pediatric Asthma Severity Score Is Associated With Critical Care Interventions https://pubmed.ncbi.nlm.nih.gov/28224093/
Intravenous Magnesium: Prompt Use for Asthma in Children Treated in the Emergency Department (IMPACT-ED): Protocol for a Multicenter Pilot Randomized Controlled Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391520/
The Pulmonary Index Score as a Clinical Assessment Tool for Acute Childhood Asthma https://pubmed.ncbi.nlm.nih.gov/21130379/
Mechanisms of Hypoxemia https://pubmed.ncbi.nlm.nih.gov/28144061/
Role of Inhaled Corticosteroids for Asthma Exacerbation in Children: An Updated Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/33013097/
2020 Focused Updates to the Asthma Management Guidelines: A Report From the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group https://pubmed.ncbi.nlm.nih.gov/33280709/
Pneumonia in Children Presenting to the Emergency Department With an Asthma Exacerbation https://pubmed.ncbi.nlm.nih.gov/27270612/
Bronchiolitis https://emedicine.medscape.com/article/961963-overview
Croup https://emedicine.medscape.com/article/962972-overview